Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Homo sapiens | fibroblast activation protein, alpha | Starlite/ChEMBL | References |
Homo sapiens | prolyl endopeptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 710 aa | 630 aa | 27.0 % |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | fibroblast activation protein, alpha | 735 aa | 597 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0191 | 0.2557 | 0.1224 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0191 | 0.2557 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0191 | 0.2557 | 0.1224 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0435 | 1 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0435 | 1 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0191 | 0.2557 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0191 | 0.2557 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0191 | 0.2557 | 0.1224 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0435 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0157 | 0.1519 | 0.1519 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0191 | 0.2557 | 0.2557 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0435 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.2557 | 0.2557 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0435 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0191 | 0.2557 | 0.1224 |
Trypanosoma brucei | prolyl endopeptidase | 0.0191 | 0.2557 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.1038 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.2 nM | Inhibitory constant against POP | ChEMBL. | 17174090 |
Ki (binding) | = 2.2 nM | Inhibitory constant against POP | ChEMBL. | 17174090 |
Ki (binding) | = 2.2 nM | Inhibition of recombinant POP | ChEMBL. | 20058865 |
Ki (binding) | = 29 nM | Inhibitiory constant against FAP | ChEMBL. | 17174090 |
Ki (binding) | = 29 nM | Inhibitiory constant against FAP | ChEMBL. | 17174090 |
Ki (binding) | = 29 nM | Inhibition of recombinant FAPalpha | ChEMBL. | 20058865 |
Ki (binding) | = 9500 nM | Inhibition constant against DPP-4 | ChEMBL. | 17174090 |
Ki (binding) | = 9500 nM | Inhibition constant against DPP-4 | ChEMBL. | 17174090 |
Ki (binding) | = 9500 nM | Inhibition of recombinant DPP4 | ChEMBL. | 20058865 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.