Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Homo sapiens | prolyl endopeptidase | Starlite/ChEMBL | References |
Homo sapiens | fibroblast activation protein, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 710 aa | 630 aa | 27.0 % |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | fibroblast activation protein, alpha | 735 aa | 597 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0191 | 0.2557 | 0.1224 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0191 | 0.2557 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0191 | 0.2557 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0191 | 0.2557 | 0.1224 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0157 | 0.1519 | 0.1519 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0435 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0191 | 0.2557 | 0.1224 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0191 | 0.2557 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0435 | 1 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0435 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0191 | 0.2557 | 0.2557 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0435 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.2557 | 0.2557 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.1038 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0435 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0191 | 0.2557 | 0.1224 |
Toxoplasma gondii | prolyl endopeptidase | 0.0191 | 0.2557 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 246 nM | Inhibitiory constant against FAP | ChEMBL. | 17174090 |
Ki (binding) | = 246 nM | Inhibitiory constant against FAP | ChEMBL. | 17174090 |
Ki (binding) | = 1359 nM | Inhibitory constant against POP | ChEMBL. | 17174090 |
Ki (binding) | = 1359 nM | Inhibitory constant against POP | ChEMBL. | 17174090 |
Ki (binding) | = 1430 nM | Inhibition constant against DPP-4 | ChEMBL. | 17174090 |
Ki (binding) | = 1430 nM | Inhibition constant against DPP-4 | ChEMBL. | 17174090 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.