Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fibroblast activation protein, alpha | Starlite/ChEMBL | References |
Homo sapiens | prolyl endopeptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | Dipeptidyl peptidase 9 | fibroblast activation protein, alpha | 735 aa | 597 aa | 24.5 % |
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 710 aa | 630 aa | 27.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0226 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0175 | 0.6507 | 0.632 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0175 | 0.6507 | 0.632 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.051 | 0.0784 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0226 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.051 | 0.0784 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0087 | 0.051 | 0.0784 |
Toxoplasma gondii | prolyl endopeptidase | 0.0175 | 0.6507 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0175 | 0.6507 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.6507 | 0.632 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.4241 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0087 | 0.051 | 0.0784 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0175 | 0.6507 | 0.632 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0175 | 0.6507 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.6507 | 0.632 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0087 | 0.051 | 0.0784 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0226 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0079 | 0 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0079 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0226 | 1 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0226 | 1 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0175 | 0.6507 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 130 nM | Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay | ChEMBL. | 23594271 |
IC50 (binding) | = 2900 nM | Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay | ChEMBL. | 23594271 |
Inhibition (binding) | = 17 % | Inhibition of DPP-4 at 500uM | ChEMBL. | 17174090 |
Inhibition (binding) | = 17 % | Inhibition of DPP-4 at 500uM | ChEMBL. | 17174090 |
Ki (binding) | = 350 nM | Inhibitiory constant against FAP | ChEMBL. | 17174090 |
Ki (binding) | = 350 nM | Inhibitiory constant against FAP | ChEMBL. | 17174090 |
Ki (binding) | = 2705 nM | Inhibitory constant against POP | ChEMBL. | 17174090 |
Ki (binding) | = 2705 nM | Inhibitory constant against POP | ChEMBL. | 17174090 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.