Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fibroblast activation protein, alpha | Starlite/ChEMBL | References |
Homo sapiens | prolyl endopeptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 710 aa | 630 aa | 27.0 % |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | fibroblast activation protein, alpha | 735 aa | 597 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.051 | 0.0784 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0087 | 0.051 | 0.0784 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.6507 | 0.632 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.4241 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0175 | 0.6507 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0175 | 0.6507 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0175 | 0.6507 | 0.632 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0226 | 1 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.051 | 0.0784 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0226 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0175 | 0.6507 | 0.632 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0079 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0079 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0226 | 1 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0175 | 0.6507 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0226 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0087 | 0.051 | 0.0784 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0175 | 0.6507 | 0.632 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0175 | 0.6507 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.6507 | 0.632 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0226 | 1 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0087 | 0.051 | 0.0784 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 353 nM | Inhibitory constant against POP | ChEMBL. | 17174090 |
Ki (binding) | = 353 nM | Inhibitory constant against POP | ChEMBL. | 17174090 |
Ki (binding) | = 2900 nM | Inhibitiory constant against FAP | ChEMBL. | 17174090 |
Ki (binding) | = 2900 nM | Inhibitiory constant against FAP | ChEMBL. | 17174090 |
Ki (binding) | = 182000 nM | Inhibition constant against DPP-4 | ChEMBL. | 17174090 |
Ki (binding) | = 182000 nM | Inhibition constant against DPP-4 | ChEMBL. | 17174090 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.