Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prolyl endopeptidase | Starlite/ChEMBL | References |
Homo sapiens | fibroblast activation protein, alpha | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | Dipeptidyl peptidase 9 | fibroblast activation protein, alpha | 735 aa | 597 aa | 24.5 % |
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 710 aa | 630 aa | 27.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0191 | 0.2557 | 0.1224 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0191 | 0.2557 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0191 | 0.2557 | 0.1224 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0435 | 1 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0191 | 0.2557 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0191 | 0.2557 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0435 | 1 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0435 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0191 | 0.2557 | 0.1224 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0191 | 0.2557 | 0.2557 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0435 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0157 | 0.1519 | 0.1519 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0435 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.2557 | 0.2557 |
Trypanosoma brucei | prolyl endopeptidase | 0.0191 | 0.2557 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0191 | 0.2557 | 0.1224 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.1038 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.7 nM | Inhibitory constant against POP | ChEMBL. | 17174090 |
Ki (binding) | = 2.7 nM | Inhibitory constant against POP | ChEMBL. | 17174090 |
Ki (binding) | = 14 nM | Inhibitiory constant against FAP | ChEMBL. | 17174090 |
Ki (binding) | = 14 nM | Inhibitiory constant against FAP | ChEMBL. | 17174090 |
Ki (binding) | = 7391 nM | Inhibition constant against DPP-4 | ChEMBL. | 17174090 |
Ki (binding) | = 7391 nM | Inhibition constant against DPP-4 | ChEMBL. | 17174090 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.