Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0469 | 0.0542 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.5809 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.1933 | 0.3134 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0163 | 0.5 |
Echinococcus granulosus | beta galactosidase | 0.0092 | 0.2952 | 0.4939 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0469 | 0.0469 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.1933 | 1 |
Echinococcus multilocularis | geminin | 0.0168 | 0.5809 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.5809 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0163 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 0.0469 | 0.0542 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0469 | 0.0469 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0028 | 0.0526 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.1933 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0065 | 0.1933 | 1 |
Echinococcus granulosus | geminin | 0.0168 | 0.5809 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0469 | 0.0542 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0469 | 0.2428 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0163 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0163 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.1933 | 0.3134 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0163 | 0.0846 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0163 | 0.5 |
Echinococcus granulosus | lamin | 0.0027 | 0.0469 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2952 | 0.2952 |
Onchocerca volvulus | 0.0027 | 0.0469 | 0.5 | |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.1933 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0065 | 0.1933 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0469 | 0.0542 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0469 | 0.0542 |
Schistosoma mansoni | beta-galactosidase | 0.0092 | 0.2952 | 0.4939 |
Schistosoma mansoni | lamin | 0.0027 | 0.0469 | 0.0542 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0065 | 0.1933 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0451 | 0.0451 |
Onchocerca volvulus | 0.0027 | 0.0469 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0469 | 0.0469 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0038 | 0.0891 | 0.1288 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0163 | 0.5 |
Echinococcus multilocularis | beta galactosidase | 0.0092 | 0.2952 | 0.4939 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0163 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0038 | 0.0891 | 0.1288 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.1933 | 0.3134 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.1933 | 0.1933 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0469 | 0.0542 |
Plasmodium vivax | hypothetical protein, conserved | 0.0028 | 0.0526 | 1 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0469 | 0.0542 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0163 | 0.0163 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0163 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0469 | 0.2428 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ka (binding) | = 0.00045 M-1 | Evaluated for binding constant of the compound with antigen meso-tetrakis (4-carboxyphenyl)porphyrin (TCPP). | ChEMBL. | 9873479 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.