Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase domain 17 | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma japonicum | ko:K06059 a disintegrin and metalloproteinase domain 17, putative | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Brugia malayi | Disintegrin family protein | ADAM metallopeptidase domain 17 | 824 aa | 724 aa | 27.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | polyADP ribose glycohydrolase | 0.0171 | 0.2747 | 0.504 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0105 | 0.1144 | 0.0753 |
Entamoeba histolytica | hypothetical protein | 0.0171 | 0.2747 | 1 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0105 | 0.1144 | 0.3877 |
Echinococcus multilocularis | poly(ADP ribose) glycohydrolase | 0.0171 | 0.2747 | 0.592 |
Loa Loa (eye worm) | Poly(ADP-ribose) glycohydrolase | 0.0171 | 0.2747 | 0.2747 |
Echinococcus granulosus | adam 17 protease | 0.0245 | 0.4555 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0171 | 0.2747 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0058 | 0 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0058 | 0 | 0.5 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0223 | 0.4013 | 1 |
Trypanosoma brucei | poly(ADP-ribose) glycohydrolase, putative | 0.0171 | 0.2747 | 0.5 |
Entamoeba histolytica | poly(ADP-ribose) glycohydrolase, putative | 0.0171 | 0.2747 | 1 |
Schistosoma mansoni | poly(ADP-ribose) glycohydrolase | 0.0171 | 0.2747 | 0.5588 |
Echinococcus multilocularis | adam 17 protease | 0.0223 | 0.4013 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0064 | 0.0128 | 0.0128 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0171 | 0.2747 | 0.5 |
Brugia malayi | Poly | 0.0171 | 0.2747 | 1 |
Toxoplasma gondii | poly(ADP-ribose) glycohydrolase | 0.0171 | 0.2747 | 1 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.014 | 0.1988 | 0.2957 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0105 | 0.1144 | 0.0641 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.014 | 0.1988 | 0.3473 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9 nM | Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme. | ChEMBL. | 12951101 |
IC50 (binding) | = 9 nM | Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme | ChEMBL. | 11992783 |
IC50 (binding) | = 9 nM | Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme. | ChEMBL. | 12951101 |
IC50 (binding) | = 9 nM | Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme | ChEMBL. | 11992783 |
IC50 (binding) | = 8000 nM | In vitro inhibition of matrix metalloprotease-1. | ChEMBL. | 12951101 |
IC50 (binding) | = 8000 nM | Inhibitory concentration of the compound against Matrix metalloproteinase-1 was determined | ChEMBL. | 11992783 |
IC50 (binding) | = 8000 nM | In vitro inhibition of matrix metalloprotease-1. | ChEMBL. | 12951101 |
IC50 (binding) | = 8000 nM | Inhibitory concentration of the compound against Matrix metalloproteinase-1 was determined | ChEMBL. | 11992783 |
IC50 (functional) | uM | Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assay; not determined | ChEMBL. | 11992783 |
IC50 (functional) | 0 uM | Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assay; not determined | ChEMBL. | 11992783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.