Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0442 | 0.0717 | 0.0717 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Loa Loa (eye worm) | adenylyl cyclase 3 | 0.1306 | 0.2488 | 0.2488 |
Loa Loa (eye worm) | hypothetical protein | 0.1202 | 0.2275 | 0.2275 |
Brugia malayi | Adenylyl cyclase protein | 0.0556 | 0.095 | 0.095 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0442 | 0.0717 | 0.0717 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0442 | 0.0717 | 0.0717 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0467 | 0.0767 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0442 | 0.0717 | 0.0717 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Onchocerca volvulus | 0.0556 | 0.095 | 0.2651 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Echinococcus multilocularis | adenylate cyclase 9 | 0.0556 | 0.095 | 0.095 |
Echinococcus granulosus | adenylate cyclase type IX | 0.084 | 0.1533 | 0.1533 |
Echinococcus granulosus | GPCR family 2 | 0.0442 | 0.0717 | 0.0717 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0093 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0442 | 0.0717 | 0.0717 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.4967 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Echinococcus granulosus | adenylate cyclase 9 | 0.0556 | 0.095 | 0.095 |
Echinococcus granulosus | DNA dependent protein kinase catalytic subunit | 0.1335 | 0.2549 | 0.2549 |
Schistosoma mansoni | kinase | 0.0312 | 0.045 | 0.045 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0312 | 0.045 | 0.045 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0865 | 0.1583 | 0.1583 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0093 | 0 | 0.5 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0093 | 0 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0442 | 0.0717 | 0.0717 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Onchocerca volvulus | Adenylate cyclase type 3 homolog | 0.1231 | 0.2334 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.1398 | 0.2678 | 0.2678 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Brugia malayi | Serine/threonine-protein kinase F42G10.2 | 0.0312 | 0.045 | 0.045 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0442 | 0.0717 | 0.0717 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0093 | 0 | 0.5 |
Giardia lamblia | GTOR | 0.0093 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0956 | 0.177 | 0.177 |
Loa Loa (eye worm) | hypothetical protein | 0.0556 | 0.095 | 0.095 |
Loa Loa (eye worm) | hypothetical protein | 0.1398 | 0.2678 | 0.2678 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0865 | 0.1583 | 0.1583 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Echinococcus multilocularis | DNA dependent protein kinase catalytic subunit | 0.1335 | 0.2549 | 0.2549 |
Onchocerca volvulus | 0.0527 | 0.089 | 0.2337 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0312 | 0.045 | 0.045 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Echinococcus multilocularis | adenylate cyclase type IX | 0.084 | 0.1533 | 0.1533 |
Schistosoma mansoni | hypothetical protein | 0.0442 | 0.0717 | 0.0717 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.4967 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0442 | 0.0717 | 0.0717 |
Onchocerca volvulus | Adenylate cyclase type 2 homolog | 0.0556 | 0.095 | 0.2651 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0442 | 0.0717 | 0.0717 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0093 | 0 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0442 | 0.0717 | 0.0717 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0442 | 0.0717 | 0.0717 |
Schistosoma mansoni | protein kinase | 0.4967 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0442 | 0.0717 | 0.0717 |
Loa Loa (eye worm) | STE/STE7/MEK4 protein kinase | 0.0312 | 0.045 | 0.045 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0956 | 0.177 | 0.177 |
Leishmania major | hypothetical protein, conserved | 0.0485 | 0.0804 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0956 | 0.177 | 0.177 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.1398 | 0.2678 | 0.2678 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.1398 | 0.2678 | 0.2678 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0093 | 0 | 0.5 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.4967 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.4967 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1 ug ml-1 | Minimal inhibitory concentration of compound against Streptococcus epidermidis ATCC12228 | ChEMBL. | 2521516 |
MIC (functional) | = 2 ug ml-1 | Minimal inhibitory concentration of compound against Staphylococcus aureus Tour | ChEMBL. | 2521516 |
MIC (functional) | = 4 ug ml-1 | Minimal inhibitory concentration of compound against Streptococcus pyogenes C203 | ChEMBL. | 2521516 |
MIC (functional) | = 4 ug ml-1 | Minimal inhibitory concentration of compound against Streptococcus pnemoniae UC41 | ChEMBL. | 2521516 |
MIC (functional) | = 4 ug ml-1 | Minimal inhibitory concentration of compound against Streptococcus faecalis AACC7080 | ChEMBL. | 2521516 |
MIC (functional) | = 8 ug ml-1 | Minimal inhibitory concentration of compound against Staphylococcus aureus Tour in an inoculum of 10e6 cfu/mL | ChEMBL. | 2521516 |
MIC (functional) | = 16 ug ml-1 | Minimal inhibitory concentration of compound against Staphylococcus aureus Tour determined in iso-sensitest broth with an inoculum of 10e4 cfu/mL | ChEMBL. | 2521516 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.