Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | epidermal growth factor receptor | 0.0632 | 0.909 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0632 | 0.909 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0675 | 1 | 0.5 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0632 | 0.909 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0339 | 0.2999 | 0.3299 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0339 | 0.2999 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0339 | 0.2999 | 0.32 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0202 | 0.0132 | 0.0145 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0675 | 1 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0675 | 1 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0339 | 0.2999 | 0.32 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0675 | 1 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0632 | 0.909 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0675 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0632 | 0.909 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0675 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0336 | 0.2924 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0339 | 0.2999 | 0.32 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0675 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0336 | 0.2924 | 0.3117 |
Echinococcus multilocularis | insulin receptor | 0.0202 | 0.0132 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.0336 | 0.2924 | 0.3117 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 mg kg-1 day-1 | Dose required to inhibit cholesterol absorption in cholesterol fed hamster model; Not determined | ChEMBL. | 9871676 |
Reduction (functional) | = -75 % | Compound was tested for percent reduction of liver cholesterol esters absorption in cholesterol fed hamster model at a dose of 3 mg/kg/day | ChEMBL. | 9871676 |
Reduction (functional) | = -43 % | Compound was tested for percent reduction of serum cholesterol absorption in cholesterol fed hamster model at a dose of 3 mg/kg/day | ChEMBL. | 9871676 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.