Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like precursor | 0.0303 | 0.3838 | 0.3838 |
Onchocerca volvulus | Cathepsin L homolog | 0.0303 | 0.3838 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0165 | 0.1292 | 0.1292 |
Echinococcus granulosus | cathepsin b | 0.0638 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0303 | 0.3838 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0246 | 0.2786 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0303 | 0.3838 | 0.3838 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0303 | 0.3838 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0303 | 0.3838 | 0.3838 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0209 | 0.2102 | 0.2102 |
Onchocerca volvulus | 0.0303 | 0.3838 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0303 | 0.3838 | 1 |
Leishmania major | cathepsin L-like protease | 0.0303 | 0.3838 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0303 | 0.3838 | 0.3838 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0303 | 0.3838 | 0.3838 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0165 | 0.1292 | 0.1292 |
Brugia malayi | cathepsin L-like precursor | 0.0209 | 0.2102 | 0.2102 |
Loa Loa (eye worm) | ctsf protein | 0.0303 | 0.3838 | 0.3838 |
Leishmania major | cathepsin L-like protease | 0.0303 | 0.3838 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.2102 | 0.2102 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0303 | 0.3838 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Leishmania major | cathepsin L-like protease | 0.0303 | 0.3838 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0303 | 0.3838 | 0.3838 |
Brugia malayi | Cathepsin L-like precursor | 0.0303 | 0.3838 | 0.3838 |
Onchocerca volvulus | 0.0303 | 0.3838 | 1 | |
Plasmodium vivax | vivapain-3 | 0.0165 | 0.1292 | 0.3366 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0303 | 0.3838 | 0.2924 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.2102 | 0.2102 |
Plasmodium vivax | vivapain-1 | 0.0165 | 0.1292 | 0.3366 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0303 | 0.3838 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Leishmania major | cathepsin L-like protease | 0.0303 | 0.3838 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0638 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0303 | 0.3838 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0246 | 0.2786 | 0.5868 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0209 | 0.2102 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0246 | 0.2786 | 0.5868 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0303 | 0.3838 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0165 | 0.1292 | 0.1292 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0303 | 0.3838 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0303 | 0.3838 | 0.2924 |
Plasmodium vivax | unspecified product | 0.0165 | 0.1292 | 0.3366 |
Brugia malayi | Cathepsin L-like precursor | 0.0209 | 0.2102 | 0.2102 |
Loa Loa (eye worm) | cathepsin B | 0.0246 | 0.2786 | 0.2786 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0303 | 0.3838 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.2102 | 0.2102 |
Leishmania major | cathepsin L-like protease | 0.0303 | 0.3838 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0303 | 0.3838 | 1 |
Plasmodium vivax | vivapain-2 | 0.0303 | 0.3838 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0638 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0303 | 0.3838 | 1 |
Onchocerca volvulus | 0.0303 | 0.3838 | 1 | |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0165 | 0.1292 | 0.1292 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0303 | 0.3838 | 0.2924 |
Trypanosoma cruzi | cysteine protease, putative | 0.0165 | 0.1292 | 0.1292 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0303 | 0.3838 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0638 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0303 | 0.3838 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.2102 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0303 | 0.3838 | 0.3838 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0209 | 0.2102 | 0.2102 |
Echinococcus granulosus | cathepsin l1 | 0.0209 | 0.2102 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0303 | 0.3838 | 1 |
Onchocerca volvulus | 0.0303 | 0.3838 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0303 | 0.3838 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0246 | 0.2786 | 0.2786 |
Brugia malayi | Cathepsin L-like precursor | 0.0303 | 0.3838 | 0.3838 |
Leishmania major | cathepsin L-like protease | 0.0303 | 0.3838 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0303 | 0.3838 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0303 | 0.3838 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0303 | 0.3838 | 0.3838 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0165 | 0.1292 | 0.1292 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0303 | 0.3838 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0638 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0303 | 0.3838 | 0.3838 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0303 | 0.3838 | 0.2924 |
Echinococcus granulosus | cathepsin l1 | 0.0303 | 0.3838 | 0.2924 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0638 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.2102 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Echinococcus granulosus | cathepsin b | 0.0638 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0303 | 0.3838 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0303 | 0.3838 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0303 | 0.3838 | 0.3838 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0165 | 0.1292 | 0.1292 |
Onchocerca volvulus | 0.0303 | 0.3838 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0246 | 0.2786 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0303 | 0.3838 | 0.3838 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0303 | 0.3838 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0165 | 0.1292 | 0.1292 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0303 | 0.3838 | 0.3838 |
Echinococcus multilocularis | cathepsin b | 0.0638 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Onchocerca volvulus | 0.0303 | 0.3838 | 1 | |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0165 | 0.1292 | 0.1292 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0303 | 0.3838 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0209 | 0.2102 | 0.2102 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0303 | 0.3838 | 0.3838 |
Onchocerca volvulus | 0.0303 | 0.3838 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0303 | 0.3838 | 0.2924 |
Echinococcus multilocularis | cathepsin b | 0.0638 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0303 | 0.3838 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0303 | 0.3838 | 0.3838 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0209 | 0.2102 | 0.2102 |
Leishmania major | cysteine peptidase A (CPA) | 0.0303 | 0.3838 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0246 | 0.2786 | 0.5 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0303 | 0.3838 | 0.3838 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0246 | 0.2786 | 0.2786 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0638 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0303 | 0.3838 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0303 | 0.3838 | 0.3838 |
Onchocerca volvulus | Cathepsin L homolog | 0.0303 | 0.3838 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0303 | 0.3838 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0303 | 0.3838 | 0.3838 |
Leishmania major | cathepsin L-like protease | 0.0303 | 0.3838 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0165 | 0.1292 | 0.1292 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.1 uM | In vitro inhibitory concentration against Selectin P in a cell-free binding assay | ChEMBL. | 9379443 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.