Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0096 | 0.0151 | 0.0151 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0096 | 0.0151 | 0.2913 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Leishmania major | hypothetical protein, conserved | 0.0277 | 0.1394 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.0148 | 0.0508 | 0.0508 |
Brugia malayi | G protein-coupled receptor | 0.0096 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | Serotonin receptor | 0.0096 | 0.0151 | 0.0151 |
Onchocerca volvulus | 0.0096 | 0.0151 | 0.2913 | |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0096 | 0.0151 | 0.07 |
Onchocerca volvulus | 0.0096 | 0.0151 | 0.2913 | |
Brugia malayi | GnHR receptor homolog | 0.0096 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Onchocerca volvulus | 0.0096 | 0.0151 | 0.2913 | |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0139 | 0.0447 | 0.5 |
Onchocerca volvulus | 0.0096 | 0.0151 | 0.2913 | |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0096 | 0.0151 | 0.0151 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0139 | 0.0447 | 0.5 |
Onchocerca volvulus | 0.0096 | 0.0151 | 0.2913 | |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | Dopamine receptor protein 1 | 0.0096 | 0.0151 | 0.0151 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0139 | 0.0447 | 0.0673 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0096 | 0.0151 | 0.2913 |
Onchocerca volvulus | 0.0096 | 0.0151 | 0.2913 | |
Onchocerca volvulus | 0.0096 | 0.0151 | 0.2913 | |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | larval opioid receptor | 0.0096 | 0.0151 | 0.0151 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0388 | 0.2162 | 0.2162 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0197 | 0.0845 | 0.0845 |
Brugia malayi | hypothetical protein | 0.0096 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0096 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0388 | 0.2162 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0447 | 0.207 |
Brugia malayi | hypothetical protein | 0.0096 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | G-protein coupled receptor | 0.0096 | 0.0151 | 0.0151 |
Brugia malayi | hypothetical protein | 0.0096 | 0.0151 | 0.0151 |
Brugia malayi | Melatonin receptor type 1A | 0.0096 | 0.0151 | 0.0151 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0096 | 0.0151 | 0.0151 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0139 | 0.0447 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Echinococcus multilocularis | muscleblind protein | 0.0148 | 0.0508 | 0.0409 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | ORL1-like opioid receptor | 0.0096 | 0.0151 | 0.0151 |
Brugia malayi | hypothetical protein | 0.0096 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0388 | 0.2162 | 0.2162 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | Dopamine receptor | 0.0096 | 0.0151 | 0.0151 |
Onchocerca volvulus | 0.0096 | 0.0151 | 0.2913 | |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0096 | 0.0151 | 0.0151 |
Brugia malayi | hypothetical protein | 0.0096 | 0.0151 | 0.0151 |
Onchocerca volvulus | 0.0096 | 0.0151 | 0.2913 | |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0096 | 0.0151 | 0.07 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0388 | 0.2162 | 0.2304 |
Onchocerca volvulus | 0.0096 | 0.0151 | 0.2913 | |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | follicle stimulating hormone receptor | 0.0096 | 0.0151 | 0.0151 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0139 | 0.0447 | 1 |
Brugia malayi | hypothetical protein | 0.0096 | 0.0151 | 0.0151 |
Brugia malayi | AKH receptor | 0.0096 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0388 | 0.2162 | 1 |
Brugia malayi | sulfakinin receptor protein | 0.0096 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0508 | 0.235 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0388 | 0.2162 | 0.2141 |
Brugia malayi | Dopamine receptor protein 2 | 0.0096 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | hypothetical protein | 0.0096 | 0.0151 | 0.0151 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0267 | 0.1324 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Echinococcus granulosus | DNA dependent protein kinase catalytic subunit | 0.0762 | 0.4737 | 0.4882 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0388 | 0.2162 | 0.457 |
Echinococcus multilocularis | conserved hypothetical protein | 0.1364 | 0.8879 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | hypothetical protein | 0.0096 | 0.0151 | 0.0151 |
Echinococcus granulosus | muscleblind protein | 0.0148 | 0.0508 | 0.038 |
Onchocerca volvulus | 0.0096 | 0.0151 | 0.2913 | |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0139 | 0.0447 | 0.0447 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0804 | 0.5025 | 0.5584 |
Onchocerca volvulus | 0.015 | 0.052 | 1 | |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0139 | 0.0447 | 0.0315 |
Onchocerca volvulus | 0.0096 | 0.0151 | 0.2913 | |
Onchocerca volvulus | 0.0096 | 0.0151 | 0.2913 | |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0139 | 0.0447 | 0.5 |
Echinococcus multilocularis | DNA dependent protein kinase catalytic subunit | 0.0762 | 0.4737 | 0.5253 |
Toxoplasma gondii | hypothetical protein | 0.0103 | 0.0199 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0096 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0508 | 0.235 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0388 | 0.2162 | 0.457 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0191 | 0.0805 | 0.0805 |
Onchocerca volvulus | 0.0096 | 0.0151 | 0.2913 | |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.0645 | 0.1122 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0096 | 0.0151 | 0.0151 |
Brugia malayi | hypothetical protein | 0.0096 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.052 | 0.2405 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | RE15519p | 0.0096 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0735 | 0.4551 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Echinococcus granulosus | hypothetical protein | 0.146 | 0.9543 | 1 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0096 | 0.0151 | 0.07 |
Echinococcus granulosus | geminin | 0.0168 | 0.0645 | 0.0526 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0139 | 0.0447 | 0.0339 |
Echinococcus multilocularis | geminin | 0.0168 | 0.0645 | 0.0566 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0139 | 0.0447 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.0645 | 0.1122 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Brugia malayi | hypothetical protein | 0.015 | 0.052 | 0.052 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0139 | 0.0447 | 0.207 |
Onchocerca volvulus | 0.0096 | 0.0151 | 0.2913 | |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0096 | 0.0151 | 0.0151 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0096 | 0.0151 | 0.0151 |
Onchocerca volvulus | 0.0096 | 0.0151 | 0.2913 | |
Brugia malayi | G-protein coupled receptor | 0.0096 | 0.0151 | 0.0151 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0148 | 0.0508 | 0.0409 |
Brugia malayi | neuropeptide F receptor | 0.0096 | 0.0151 | 0.0151 |
Brugia malayi | hypothetical protein | 0.0096 | 0.0151 | 0.0151 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0139 | 0.0447 | 1 |
Brugia malayi | putative neuropeptide receptor | 0.0096 | 0.0151 | 0.0151 |
Onchocerca volvulus | 0.0096 | 0.0151 | 0.2913 | |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0151 | 0.07 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | <= 0.12 ug ml-1 | In vitro minimum inhibitory concentration of the compound against Streptococcus species; Range is 0.06-0.12 ug/mL | ChEMBL. | 15214775 |
MIC (functional) | = 2 ug ml-1 | In vitro minimum inhibitory concentration of the compound against Staphylococcus species; Range is 1-2 ug/mL | ChEMBL. | 15214775 |
MIC (functional) | = 4 ug ml-1 | In vitro minimum inhibitory concentration of the compound against Enterococcus species; Range is 2-4 ug/mL | ChEMBL. | 15214775 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.