Detailed information for compound 403282

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1769.66 | Formula: C81H108Cl2N11O27P
  • H donors: 23 H acceptors: 21 LogP: -1.93 Rotable bonds: 31
    Rule of 5 violations (Lipinski): 4
  • SMILES: CCCCCCCCCCNCCN[C@@]1(C)C[C@H](O[C@H]2[C@@H](O[C@@H]([C@H]([C@@H]2O)O)CO)Oc2c3Oc4ccc(cc4Cl)[C@@H](O)[C@@H]4NC(=O)[C@H](NC(=O)[C@H]5c(c3)cc2Oc2ccc(cc2Cl)[C@@H](O)[C@@](C(=O)N[C@H](C(=O)N5)CC(=O)N)(C)NC(=O)[C@@H](CC(C)C)NC)c2ccc(c(c2)c2c([C@@H](NC4=O)C(=O)O)cc(c(c2O)CNCP(=O)(O)O)O)O)O[C@H](C1O)C
  • InChi: 1S/C81H108Cl2N11O27P/c1-8-9-10-11-12-13-14-15-22-86-23-24-88-80(5)33-58(116-38(4)70(80)103)120-69-67(102)66(101)56(35-95)119-78(69)121-68-54-29-42-30-55(68)118-53-21-18-41(28-47(53)83)71(104)81(6,94-73(106)48(85-7)25-37(2)3)79(112)89-49(32-57(84)98)72(105)90-61(42)75(108)91-60-39-16-19-50(96)43(26-39)59-44(31-51(97)45(65(59)100)34-87-36-122(113,114)115)62(77(110)111)92-76(109)63(93-74(60)107)64(99)40-17-20-52(117-54)46(82)27-40/h16-21,26-31,37-38,48-49,56,58,60-64,66-67,69-71,78,85-88,95-97,99-104H,8-15,22-25,32-36H2,1-7H3,(H2,84,98)(H,89,112)(H,90,105)(H,91,108)(H,92,109)(H,93,107)(H,94,106)(H,110,111)(H2,113,114,115)/t38-,48+,49-,56+,58-,60+,61+,62+,63-,64+,66+,67-,69+,70?,71+,78-,80-,81+/m0/s1
  • InChiKey: BHJQDLZFYNILHA-HSPHEALBSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0042 0.0014 0.003
Onchocerca volvulus 0.008 0.0228 0.1294
Echinococcus multilocularis g protein coupled receptor 0.008 0.0228 0.0228
Plasmodium falciparum glutathione reductase 0.0111 0.0399 0.2851
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Schistosoma mansoni biogenic amine receptor 0.008 0.0228 0.0506
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0018 0.011
Brugia malayi putative neuropeptide receptor 0.008 0.0228 0.0809
Echinococcus multilocularis cyclins 0.0175 0.0758 0.0758
Echinococcus multilocularis cyclin b3 0.0175 0.0758 0.0758
Echinococcus multilocularis cyclin B 0.0337 0.1674 0.1674
Entamoeba histolytica cell division protein kinase 2, putative 0.0283 0.1368 0.817
Echinococcus granulosus cyclin y 0.0042 0.0013 0.0013
Schistosoma mansoni adenoreceptor 0.008 0.0228 0.0506
Schistosoma mansoni hypothetical protein 0.0074 0.0192 0.0428
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0124 0.0277
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0839 0.4498 1
Echinococcus granulosus cyclins 0.0175 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus allatostatin A receptor 0.008 0.0228 0.0228
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0015 0.0012
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.008 0.0228 0.0228
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0195 0.087 0.1935
Schistosoma mansoni biogenic amine receptor 0.008 0.0228 0.0506
Toxoplasma gondii hypothetical protein 0.0042 0.0013 0.0091
Trypanosoma brucei mitotic cyclin 0.0042 0.0013 0.0075
Echinococcus multilocularis cyclin dependent kinase 1 0.0283 0.1368 0.1368
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0042 0.0013 0.0013
Brugia malayi neuropeptide F receptor 0.008 0.0228 0.0809
Loa Loa (eye worm) melatonin receptor type 1A 0.008 0.0228 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0013 0.0075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Echinococcus granulosus cyclin y 0.0042 0.0013 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0018 0.011
Brugia malayi hypothetical protein 0.0042 0.0013 0.0045
Echinococcus multilocularis cyclins 0.0175 0.0758 0.0758
Brugia malayi hypothetical protein 0.0042 0.0013 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Trichomonas vaginalis cyclin B3, putative 0.0042 0.0013 0.0075
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Schistosoma mansoni biogenic amine receptor 0.008 0.0228 0.0506
Trichomonas vaginalis cyclins, putative 0.0042 0.0013 0.0075
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0042 0.0013 0.0013
Echinococcus multilocularis G1:S specific cyclin D1 0.0042 0.0013 0.0013
Echinococcus granulosus orexin receptor type 2 0.008 0.0228 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0013 0.0075
Echinococcus granulosus neuropeptides capa receptor 0.008 0.0228 0.0228
Schistosoma mansoni opsin-like receptor 0.008 0.0228 0.0506
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0042 0.0014 0.0014
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0013 0.0045
Entamoeba histolytica hypothetical protein 0.0074 0.0192 0.1149
Brugia malayi TAR-binding protein 0.0062 0.0124 0.0443
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0042 0.0014 0.0048
Echinococcus granulosus g protein coupled receptor 0.008 0.0228 0.0228
Echinococcus multilocularis cyclins 0.0175 0.0758 0.0758
Echinococcus granulosus neutral alpha glucosidase AB 0.0043 0.0018 0.0018
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0228 0.0228
Echinococcus granulosus cyclins 0.0042 0.0013 0.0013
Echinococcus multilocularis neuropeptides capa receptor 0.008 0.0228 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0013 0.0075
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Brugia malayi G protein-coupled receptor 0.008 0.0228 0.0809
Brugia malayi Cyclin, N-terminal domain containing protein 0.0337 0.1674 0.5956
Schistosoma mansoni cyclin d 0.0042 0.0013 0.0028
Schistosoma mansoni cyclin G 0.0042 0.0013 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.008 0.0228 0.0506
Echinococcus multilocularis neuropeptide receptor 0.008 0.0228 0.0228
Echinococcus multilocularis GPCR, family 2 0.0042 0.0014 0.0014
Toxoplasma gondii cyclin 4, putative 0.0042 0.0013 0.0091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0015 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0124 0.0277
Loa Loa (eye worm) hypothetical protein 0.0337 0.1674 0.3722
Entamoeba histolytica hypothetical protein 0.0042 0.0013 0.0075
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0015 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Echinococcus multilocularis cyclin A3 4 0.0042 0.0013 0.0013
Brugia malayi hypothetical protein 0.0074 0.0192 0.0685
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.008 0.0228 0.0506
Trypanosoma cruzi cysteine peptidase, putative 0.0076 0.0204 0.122
Schistosoma mansoni hypothetical protein 0.008 0.0228 0.0506
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0042 0.0013 0.0091
Echinococcus multilocularis cyclin y 0.0042 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0283 0.1368 0.3041
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0228 0.0228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Brugia malayi Serotonin receptor 0.008 0.0228 0.0809
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0042 0.0013 0.0013
Entamoeba histolytica cyclin family protein 0.0175 0.0758 0.4527
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus serotonin receptor 0.008 0.0228 0.0228
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0018 0.011
Leishmania major cathepsin L-like protease 0.0076 0.0204 0.122
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.008 0.0228 0.0228
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.0228 0.0228
Brugia malayi Dopamine receptor 0.008 0.0228 0.0809
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.008 0.0228 0.0506
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0192 0.0428
Echinococcus multilocularis g-protein coupled receptor 0.008 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Leishmania major mitotic cyclin, putative 0.0042 0.0013 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.008 0.0228 0.0228
Trichomonas vaginalis cyclin A, putative 0.0042 0.0013 0.0075
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Schistosoma mansoni hypothetical protein 0.0042 0.0014 0.003
Echinococcus granulosus neuropeptide FF receptor 2 0.008 0.0228 0.0228
Brugia malayi latrophilin 2 splice variant baaae 0.0091 0.029 0.1032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0228 0.0506
Onchocerca volvulus 0.008 0.0228 0.1294
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0134 0.0528 0.1879
Leishmania major alpha glucosidase II subunit, putative 0.0043 0.0018 0.011
Plasmodium vivax thioredoxin reductase, putative 0.0111 0.0399 0.2851
Trichomonas vaginalis cyclin B, putative 0.0042 0.0013 0.0075
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0228 0.0506
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0018 0.011
Echinococcus multilocularis neuropeptide Y receptor 0.008 0.0228 0.0228
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.008 0.0228 0.0506
Trypanosoma cruzi cyclin 6, putative 0.0337 0.1674 1
Schistosoma mansoni amine GPCR 0.008 0.0228 0.0506
Schistosoma mansoni cyclin k 0.0042 0.0013 0.0028
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0329 0.1626 0.3615
Giardia lamblia Hypothetical protein 0.0175 0.0758 0.4486
Echinococcus granulosus tar DNA binding protein 0.0062 0.0124 0.0124
Schistosoma mansoni cyclin B3 0.0539 0.2811 0.6249
Trichomonas vaginalis cyclins, putative 0.0205 0.0929 0.5548
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.008 0.0228 0.0228
Echinococcus multilocularis G protein coupled receptor 139 0.0145 0.0592 0.0592
Trichomonas vaginalis cyclins, putative 0.0042 0.0013 0.0075
Trypanosoma cruzi cdc2-related kinase 1 0.0283 0.1368 0.817
Leishmania major cathepsin L-like protease 0.0076 0.0204 0.122
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0013 0.0028
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0042 0.0014 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0228 0.0228
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.008 0.0228 0.0506
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.008 0.0228 0.0809
Loa Loa (eye worm) thioredoxin reductase 0.0111 0.0399 0.0887
Brugia malayi G-protein coupled receptor 0.008 0.0228 0.0809
Toxoplasma gondii cyclin dependent kinase binding protein 0.0042 0.0013 0.0091
Brugia malayi gonadotropin-releasing hormone receptor 2 0.008 0.0228 0.0809
Trypanosoma cruzi cyclin 9, putative 0.0042 0.0013 0.0075
Schistosoma mansoni neuropeptide F-like receptor 0.008 0.0228 0.0506
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.167 0.9174 0.9174
Schistosoma mansoni opsin-like receptor 0.008 0.0228 0.0506
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0013 0.0045
Onchocerca volvulus 0.008 0.0228 0.1294
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1816 1 1
Echinococcus granulosus hypothetical protein 0.008 0.0228 0.0228
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0013 0.0028
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Brugia malayi glutathione reductase 0.0111 0.0399 0.1419
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Echinococcus granulosus GPCR family 2 0.0042 0.0014 0.0014
Trypanosoma cruzi trypanothione reductase, putative 0.0111 0.0399 0.2383
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Schistosoma mansoni amine GPCR 0.008 0.0228 0.0506
Trichomonas vaginalis cyclins, putative 0.0337 0.1674 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0111 0.0399 0.0399
Trichomonas vaginalis cyclin B3, putative 0.0042 0.0013 0.0075
Echinococcus granulosus neuropeptide receptor 0.0145 0.0592 0.0592
Trypanosoma cruzi mitotic cyclin, putative 0.0042 0.0013 0.0075
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0013 0.0045
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0228 0.0506
Trichomonas vaginalis cyclins, putative 0.0337 0.1674 1
Onchocerca volvulus 0.008 0.0228 0.1294
Echinococcus granulosus 7TM GPCR rhodopsin 0.008 0.0228 0.0228
Schistosoma mansoni alpha-glucosidase 0.0167 0.0718 0.1596
Trichomonas vaginalis cyclin B, putative 0.0042 0.0013 0.0075
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0015 0.0087
Schistosoma mansoni hypothetical protein 0.008 0.0228 0.0506
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0283 0.1368 0.1368
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0015 0.0015
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0042 0.0013 0.0028
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.0228 0.0228
Echinococcus multilocularis allatostatin A receptor 0.008 0.0228 0.0228
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0013 0.0028
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.008 0.0228 0.1294
Echinococcus multilocularis neuropeptide Y receptor 0.008 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus neuropeptide receptor 0.008 0.0228 0.0228
Onchocerca volvulus 0.0337 0.1674 1
Trypanosoma cruzi cdc2-related kinase 3 0.0283 0.1368 0.817
Plasmodium falciparum cyclin 0.0175 0.0758 0.55
Echinococcus granulosus cyclin dependent kinase 5 0.0283 0.1368 0.1368
Brugia malayi cell division control protein 2 homolog 0.0283 0.1368 0.4866
Echinococcus multilocularis cyclins 0.0175 0.0758 0.0758
Echinococcus granulosus lysosomal alpha glucosidase 0.0195 0.087 0.087
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.008 0.0228 0.0228
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0013 0.0045
Onchocerca volvulus 0.008 0.0228 0.1294
Onchocerca volvulus 0.008 0.0228 0.1294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Onchocerca volvulus 0.008 0.0228 0.1294
Loa Loa (eye worm) hypothetical protein 0.0163 0.0692 0.1538
Brugia malayi Calcitonin receptor-like protein seb-1 0.0134 0.0528 0.1879
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus neuropeptide Y receptor 0.008 0.0228 0.0228
Echinococcus granulosus cyclin B3 1 0.0175 0.0758 0.0758
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0124 0.0277
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0013 0.0075
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0402 0.2036 0.4527
Entamoeba histolytica cyclin, putative 0.0337 0.1674 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.008 0.0228 0.0228
Loa Loa (eye worm) cyclin domain-containing protein 0.0539 0.2811 0.6249
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0134 0.0528 0.1175
Echinococcus granulosus thioredoxin glutathione reductase 0.0111 0.0399 0.0399
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0283 0.1368 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.008 0.0228 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Giardia lamblia Cyclin A 0.0175 0.0758 0.4486
Schistosoma mansoni hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.008 0.0228 0.0228
Onchocerca volvulus 0.008 0.0228 0.1294
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.008 0.0228 0.0506
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0228 0.0228
Echinococcus granulosus thyrotropin releasing hormone receptor 0.008 0.0228 0.0228
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.008 0.0228 0.0506
Onchocerca volvulus 0.008 0.0228 0.1294
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Schistosoma mansoni neuropeptide receptor 0.008 0.0228 0.0506
Brugia malayi putative neuropeptide receptor NPR1 0.008 0.0228 0.0809
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0042 0.0013 0.0013
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0539 0.2811 0.2811
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0042 0.0013 0.0091
Echinococcus granulosus peptide allatostatin:somatostatin 0.008 0.0228 0.0228
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0018 0.011
Echinococcus granulosus cyclin dependent kinase 0.0283 0.1368 0.1368
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Onchocerca volvulus 0.008 0.0228 0.1294
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0015 0.0015
Plasmodium vivax protein kinase Crk2 0.0283 0.1368 1
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0839 0.4498 0.4498
Brugia malayi Dopamine receptor protein 2 0.008 0.0228 0.0809
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.008 0.0228 0.0228
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0281 0.1356 1
Brugia malayi larval opioid receptor 0.008 0.0228 0.0809
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0228 0.0506
Schistosoma mansoni neuropeptide receptor 0.008 0.0228 0.0506
Echinococcus multilocularis cyclin k 0.0042 0.0013 0.0013
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0124 0.0277
Leishmania major trypanothione reductase 0.0111 0.0399 0.2383
Loa Loa (eye worm) hypothetical protein 0.0337 0.1674 0.3722
Schistosoma mansoni hypothetical protein 0.0042 0.0014 0.003
Leishmania major cathepsin L-like protease 0.0076 0.0204 0.122
Trypanosoma cruzi cyclin, putative 0.0337 0.1674 1
Loa Loa (eye worm) CYL-1 protein 0.0042 0.0013 0.0028
Echinococcus multilocularis neutral alpha glucosidase AB 0.0043 0.0018 0.0018
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.008 0.0228 0.0506
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus tachykinin peptides receptor 99D 0.008 0.0228 0.0228
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.008 0.0228 0.0228
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0124 0.0277
Trypanosoma cruzi mitotic cyclin, putative 0.0042 0.0013 0.0075
Schistosoma mansoni amine GPCR 0.008 0.0228 0.0506
Echinococcus granulosus cyclins 0.0175 0.0758 0.0758
Loa Loa (eye worm) G-protein coupled receptor 0.008 0.0228 0.0506
Onchocerca volvulus 0.008 0.0228 0.1294
Echinococcus granulosus neuropeptide Y receptor 0.008 0.0228 0.0228
Echinococcus granulosus fmrfamide receptor 0.008 0.0228 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0175 0.0758 0.4527
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0015 0.0087
Loa Loa (eye worm) hypothetical protein 0.0042 0.0015 0.0032
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus multilocularis neuropeptides capa receptor 0.008 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus cyclin A3 4 0.0042 0.0013 0.0013
Trichomonas vaginalis cyclin B3, putative 0.0175 0.0758 0.4527
Entamoeba histolytica cyclin C, putative 0.0042 0.0013 0.0075
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.008 0.0228 0.0506
Onchocerca volvulus 0.008 0.0228 0.1294
Echinococcus multilocularis cyclin 0.0042 0.0013 0.0013
Trypanosoma brucei cyclin 3 0.0042 0.0013 0.0075
Echinococcus multilocularis fmrfamide receptor 0.008 0.0228 0.0228
Trichomonas vaginalis cyclin B, putative 0.0337 0.1674 1
Leishmania major cyclin 0.0337 0.1674 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0228 0.0228
Trypanosoma cruzi major cysteine proteinase, putative 0.006 0.0112 0.0672
Echinococcus granulosus cyclins 0.0175 0.0758 0.0758
Echinococcus multilocularis orexin receptor type 2 0.008 0.0228 0.0228
Trypanosoma cruzi cyclin, putative 0.0337 0.1674 1
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0337 0.1674 1
Brugia malayi Melatonin receptor type 1A 0.008 0.0228 0.0809
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0018 0.011
Trichomonas vaginalis cyclin B, putative 0.0337 0.1674 1
Echinococcus multilocularis somatostatin receptor 0.008 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Trichomonas vaginalis cyclins, putative 0.0175 0.0758 0.4527
Brugia malayi AKH receptor 0.008 0.0228 0.0809
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0013 0.0045
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0013 0.0028
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0839 0.4498 0.4498
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Loa Loa (eye worm) glutathione reductase 0.0111 0.0399 0.0887
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Schistosoma mansoni histamine h1 receptor 0.008 0.0228 0.0506
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Echinococcus granulosus cyclin G2 0.0042 0.0013 0.0013
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0248 0.1174 0.8095
Echinococcus granulosus biogenic amine 5HT receptor 0.008 0.0228 0.0228
Giardia lamblia Kinase, CMGC CDK 0.0283 0.1368 0.8156
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0043 0.0018 0.0041
Echinococcus multilocularis serotonin receptor 0.008 0.0228 0.0228
Trichomonas vaginalis cyclins, putative 0.0337 0.1674 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0015 0.0087
Brugia malayi GnHR receptor homolog 0.008 0.0228 0.0809
Echinococcus multilocularis cyclin G2 0.0042 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0124 0.0443
Schistosoma mansoni g1/s-specific cyclin C 0.0042 0.0013 0.0028
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0124 0.0124
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0253 0.1198 0.8342
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Onchocerca volvulus 0.008 0.0228 0.1294
Trichomonas vaginalis cyclins, putative 0.0337 0.1674 1
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Giardia lamblia G2/mitotic-specific cyclin B 0.0337 0.1674 1
Schistosoma mansoni alpha-glucosidase 0.0167 0.0718 0.1596
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0018 0.011
Echinococcus multilocularis g protein coupled receptor 0.008 0.0228 0.0228
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.008 0.0228 0.0809
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.0228 0.0228
Schistosoma mansoni neuropeptide receptor 0.0145 0.0592 0.1316
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.0228 0.0228
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0015 0.0052
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0018 0.011
Loa Loa (eye worm) TYRA-2 protein 0.008 0.0228 0.0506
Brugia malayi ORL1-like opioid receptor 0.008 0.0228 0.0809
Schistosoma mansoni neuropeptide receptor 0.008 0.0228 0.0506
Echinococcus granulosus cyclin 0.0042 0.0013 0.0013
Onchocerca volvulus 0.008 0.0228 0.1294
Echinococcus multilocularis cyclins 0.0175 0.0758 0.0758
Echinococcus multilocularis serotonin receptor 0.008 0.0228 0.0228
Echinococcus multilocularis cyclin dependent kinase 0.0283 0.1368 0.1368
Trichomonas vaginalis maltase-glucoamylase, putative 0.0043 0.0018 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.008 0.0228 0.0506
Echinococcus multilocularis cyclin dependent kinase 1 0.0283 0.1368 0.1368
Trichomonas vaginalis cyclin B, putative 0.0337 0.1674 1
Trypanosoma cruzi cdc2-related kinase 3 0.0283 0.1368 0.817
Echinococcus multilocularis lysosomal alpha glucosidase 0.0195 0.087 0.087
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0167 0.0997
Brugia malayi G protein-coupled receptor F59B2.13 0.008 0.0228 0.0809
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Schistosoma mansoni hypothetical protein 0.0042 0.0013 0.0028
Schistosoma mansoni Cyclin fold protein 0.0042 0.0013 0.0028
Schistosoma mansoni hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus cyclins 0.0175 0.0758 0.0758
Echinococcus granulosus sex peptide receptor 0.008 0.0228 0.0228
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0042 0.0013 0.0028
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.008 0.0228 0.0506
Loa Loa (eye worm) hypothetical protein 0.0839 0.4498 1
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Echinococcus multilocularis fmrfamide receptor 0.008 0.0228 0.0228
Entamoeba histolytica cyclin, domain containing protein 0.0042 0.0013 0.0075
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0228 0.0228
Schistosoma mansoni growth hormone secretagogue receptor 0.008 0.0228 0.0506
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0015 0.0032
Schistosoma mansoni myosin xvIII 0.008 0.0228 0.0506
Entamoeba histolytica cell division protein kinase 2, putative 0.0283 0.1368 0.817
Plasmodium vivax glutathione reductase, putative 0.0111 0.0399 0.2851
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Trypanosoma cruzi cysteine peptidase, putative 0.0076 0.0204 0.122
Trypanosoma brucei cdc2-related kinase 1 0.0283 0.1368 0.817
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0228 0.0228
Brugia malayi RE15519p 0.008 0.0228 0.0809
Schistosoma mansoni biogenic amine (5HT) receptor 0.008 0.0228 0.0506
Echinococcus granulosus cyclins 0.0175 0.0758 0.0758
Echinococcus granulosus cyclin G2 0.0042 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0042 0.0013 0.0028
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.008 0.0228 0.0228
Echinococcus granulosus somatostatin receptor 0.008 0.0228 0.0228
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0015 0.0015
Echinococcus multilocularis cyclins 0.0175 0.0758 0.0758
Echinococcus multilocularis alpha 1A adrenergic receptor 0.008 0.0228 0.0228
Entamoeba histolytica cyclin family protein 0.0175 0.0758 0.4527
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0281 0.1356 1
Brugia malayi hypothetical protein 0.0402 0.2036 0.7244
Schistosoma mansoni amine GPCR 0.008 0.0228 0.0506
Echinococcus granulosus alpha 1A adrenergic receptor 0.008 0.0228 0.0228
Entamoeba histolytica hypothetical protein 0.0074 0.0192 0.1149
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0124 0.0277
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0042 0.0013 0.0075
Brugia malayi sulfakinin receptor protein 0.008 0.0228 0.0809
Loa Loa (eye worm) hypothetical protein 0.0042 0.0014 0.003
Schistosoma mansoni hypothetical protein 0.0091 0.029 0.0645
Loa Loa (eye worm) G-protein coupled receptor 0.008 0.0228 0.0506
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0228 0.0228
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0124 0.0277
Schistosoma mansoni alpha-1 adrenergic receptor 0.008 0.0228 0.0506
Echinococcus granulosus 7tm_1 domain containing protein 0.008 0.0228 0.0228
Echinococcus granulosus neuropeptide s receptor 0.008 0.0228 0.0228
Schistosoma mansoni neuropeptide F-like receptor 0.008 0.0228 0.0506
Echinococcus multilocularis Cyclin L1 0.0042 0.0013 0.0013
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0283 0.1368 0.3041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.008 0.0228 0.0228
Brugia malayi Cyclin, N-terminal domain containing protein 0.0337 0.1674 0.5956
Loa Loa (eye worm) latrophilin receptor protein 2 0.0042 0.0014 0.003
Trypanosoma cruzi cysteine peptidase, putative 0.0076 0.0204 0.122
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.008 0.0228 0.0228
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0253 0.1198 0.8342
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0 0.5
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Loa Loa (eye worm) hypothetical protein 0.0091 0.029 0.0645
Echinococcus granulosus g-protein coupled receptor 0.008 0.0228 0.0228
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0 0.5
Mycobacterium tuberculosis Probable reductase 0.0253 0.1198 0.8342
Mycobacterium tuberculosis Probable oxidoreductase 0.0281 0.1356 1
Echinococcus granulosus cyclin k 0.0042 0.0013 0.0013
Brugia malayi Latrophilin receptor protein 2 0.0042 0.0014 0.0048
Echinococcus granulosus neuropeptides capa receptor 0.008 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Entamoeba histolytica cyclin, domain containing protein 0.0042 0.0013 0.0075
Brugia malayi Serotonin/octopamine receptor family protein 7 0.008 0.0228 0.0809
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Loa Loa (eye worm) hypothetical protein 0.0134 0.0528 0.1175
Toxoplasma gondii thioredoxin reductase 0.0111 0.0399 0.2917
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus G1:S specific cyclin D1 0.0042 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Brugia malayi Glycosyl hydrolases family 31 protein 0.0043 0.0018 0.0065
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0015 0.0087
Brugia malayi Thioredoxin reductase 0.0111 0.0399 0.1419
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0228 0.0228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0204 0.122
Brugia malayi Cyclin C 0.0042 0.0013 0.0045
Echinococcus multilocularis biogenic amine (5HT) receptor 0.008 0.0228 0.0228
Brugia malayi Dopamine receptor protein 1 0.008 0.0228 0.0809
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0253 0.1198 0.8342
Trichomonas vaginalis CMGC family protein kinase 0.0283 0.1368 0.817
Entamoeba histolytica hypothetical protein 0.0074 0.0192 0.1149
Schistosoma mansoni hypothetical protein 0.0042 0.0014 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0015 0.0087
Entamoeba histolytica hypothetical protein 0.0074 0.0192 0.1149
Schistosoma mansoni amine GPCR 0.008 0.0228 0.0506
Trichomonas vaginalis cyclin D, putative 0.0042 0.0013 0.0075
Trichomonas vaginalis cyclin B, putative 0.0175 0.0758 0.4527
Brugia malayi G-protein coupled receptor 0.008 0.0228 0.0809
Onchocerca volvulus 0.008 0.0228 0.1294
Echinococcus granulosus biogenic amine 5HT receptor 0.008 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus cyclin b3 0.0175 0.0758 0.0758
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0281 0.1356 1
Onchocerca volvulus 0.008 0.0228 0.1294
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0015 0.0087
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Trichomonas vaginalis sucrase-isomaltase, putative 0.0043 0.0018 0.011
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.008 0.0228 0.0506
Trypanosoma brucei mitotic cyclin 6 0.0337 0.1674 1
Brugia malayi hypothetical protein 0.008 0.0228 0.0809
Echinococcus multilocularis tachykinin peptides receptor 99D 0.008 0.0228 0.0228
Brugia malayi Glycosyl hydrolases family 31 protein 0.0195 0.087 0.3097
Echinococcus granulosus cyclin B 0.0337 0.1674 0.1674
Loa Loa (eye worm) cyclin C 0.0042 0.0013 0.0028
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0283 0.1368 0.3041
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0228 0.0228
Echinococcus multilocularis dro:myosuppressin receptor 0.008 0.0228 0.0228
Trypanosoma cruzi cdc2-related kinase 1 0.0283 0.1368 0.817
Schistosoma mansoni biogenic amine (5HT) receptor 0.008 0.0228 0.0506
Trypanosoma brucei cyclin 9 0.0042 0.0013 0.0075
Echinococcus granulosus g protein coupled receptor 0.008 0.0228 0.0228
Echinococcus granulosus dro:myosuppressin receptor 0.008 0.0228 0.0228
Schistosoma mansoni alpha glucosidase 0.0043 0.0018 0.0041
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0013 0.0045
Schistosoma mansoni cyclin l 0.0042 0.0013 0.0028
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus multilocularis sex peptide receptor 0.008 0.0228 0.0228
Echinococcus granulosus g protein coupled receptor 0.008 0.0228 0.0228
Echinococcus multilocularis cyclins 0.0175 0.0758 0.0758
Brugia malayi follicle stimulating hormone receptor 0.0329 0.1626 0.5785
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0283 0.1368 0.817
Trypanosoma brucei glucosidase, putative 0.0043 0.0018 0.011
Brugia malayi cyclin fold protein 1 variant b 0.0042 0.0013 0.0045
Brugia malayi Protein kinase domain containing protein 0.0283 0.1368 0.4866
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0042 0.0014 0.0014
Leishmania major cyclin 9, putative 0.0042 0.0013 0.0075
Echinococcus granulosus neuropeptide receptor A26 0.008 0.0228 0.0228
Schistosoma mansoni hypothetical protein 0.0042 0.0013 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0283 0.1368 0.3041
Plasmodium falciparum thioredoxin reductase 0.0111 0.0399 0.2851
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0013 0.0028
Trichomonas vaginalis cyclin B, putative 0.0337 0.1674 1
Echinococcus multilocularis neuropeptide receptor A26 0.008 0.0228 0.0228
Brugia malayi Cyclin, N-terminal domain containing protein 0.0539 0.2811 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0015 0.0032
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0042 0.0014 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0228 0.0228
Schistosoma mansoni cyclin G2 0.0042 0.0013 0.0028
Loa Loa (eye worm) neuropeptide F receptor 0.008 0.0228 0.0506
Echinococcus granulosus cyclin t1 0.0042 0.0013 0.0013
Echinococcus granulosus cyclin dependent kinase 1 0.0283 0.1368 0.1368
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Brugia malayi Tachykinin-like peptides receptor 99D 0.008 0.0228 0.0809
Onchocerca volvulus 0.0113 0.0409 0.2385
Entamoeba histolytica cyclin, putative 0.0175 0.0758 0.4527
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0013 0.0028
Echinococcus multilocularis cyclin G2 0.0042 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.028 0.1351 0.3003
Plasmodium falciparum protein kinase 5 0.0283 0.1368 1
Trypanosoma cruzi CYC2-like cyclin, putative 0.0337 0.1674 1
Echinococcus multilocularis g protein coupled receptor 0.008 0.0228 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0228 0.0228
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0192 0.0192
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0228 0.0228
Trypanosoma brucei trypanothione reductase 0.0111 0.0399 0.2383
Brugia malayi Serotonin receptor 0.008 0.0228 0.0809
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0018 0.011
Echinococcus multilocularis cyclin B3 1 0.0175 0.0758 0.0758
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0018 0.011
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0018 0.011
Echinococcus multilocularis cyclin t1 0.0042 0.0013 0.0013
Schistosoma mansoni peptide (allatostatin)-like receptor 0.008 0.0228 0.0506
Echinococcus multilocularis cyclin dependent kinase 5 0.0283 0.1368 0.1368
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0013 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0013 0.0075
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.008 0.0228 0.0228
Trichomonas vaginalis cyclin D, putative 0.0175 0.0758 0.4527
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.008 0.0228 0.0506
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0253 0.1198 0.8342
Echinococcus multilocularis G-protein coupled receptor, putative 0.008 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0402 0.2036 0.4527
Echinococcus multilocularis lysosomal alpha glucosidase 0.0195 0.087 0.087
Loa Loa (eye worm) hypothetical protein 0.0042 0.0013 0.0028
Trichomonas vaginalis CMGC family protein kinase 0.0283 0.1368 0.817
Trypanosoma brucei cdc2-related kinase 3 0.0283 0.1368 0.817
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0043 0.0018 0.0135
Brugia malayi neuropeptide F receptor 0.008 0.0228 0.0809
Toxoplasma gondii hypothetical protein 0.0132 0.0521 0.3808
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0015 0.0015
Schistosoma mansoni opsin-like receptor 0.008 0.0228 0.0506
Onchocerca volvulus Neuropeptide F receptor homolog 0.008 0.0228 0.1294
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0283 0.1368 0.817
Onchocerca volvulus 0.008 0.0228 0.1294
Schistosoma mansoni neuropeptide f receptor 76f 0.008 0.0228 0.0506
Echinococcus multilocularis neuropeptide s receptor 0.008 0.0228 0.0228
Trichomonas vaginalis cyclin A, putative 0.0337 0.1674 1
Echinococcus multilocularis cyclin y 0.0042 0.0013 0.0013
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.008 0.0228 0.0809
Giardia lamblia Kinase, CMGC CDK 0.0283 0.1368 0.8156
Echinococcus multilocularis neuropeptide receptor 0.0145 0.0592 0.0592
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0015 0.0087
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus Cyclin L1 0.0042 0.0013 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0228 0.0228
Trichomonas vaginalis cyclin D, putative 0.0175 0.0758 0.4527
Mycobacterium tuberculosis Probable dehydrogenase 0.0253 0.1198 0.8342
Schistosoma mansoni cyclins 0.0175 0.0758 0.1685
Loa Loa (eye worm) hypothetical protein 0.008 0.0228 0.0506
Echinococcus granulosus G protein coupled receptor 139 0.008 0.0228 0.0228
Trichomonas vaginalis CMGC family protein kinase 0.0283 0.1368 0.817
Loa Loa (eye worm) RNA binding protein 0.0062 0.0124 0.0277
Schistosoma mansoni serine/threonine protein kinase 0.0283 0.1368 0.3041
Brugia malayi RNA binding protein 0.0062 0.0124 0.0443
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0539 0.2811 0.2811
Leishmania major mitotic cyclin, putative 0.0042 0.0013 0.0075
Trypanosoma cruzi cruzipain precursor, putative 0.0076 0.0204 0.122
Schistosoma mansoni cyclin B 0.0337 0.1674 0.3722
Loa Loa (eye worm) neuropeptide F receptor 0.008 0.0228 0.0506

Activities

Activity type Activity value Assay description Source Reference
Cmax (ADMET) = 45 ug ml-1 Cmax (Tissue distribution) of compound was determined at a dose of 5 mg/kg in human ChEMBL. 14622994
Cmin (ADMET) = 5 ug ml-1 Cmin (Clearance) of compound was determined at a dose of 5 mg/kg in human ChEMBL. 14622994
IC50 (functional) = 10 ug ml-1 Inhibitory activity of compound against VanA Enterococcus faecalis MGH-01 ChEMBL. 14622994
IC50 (functional) = 15 ug ml-1 Inhibitory activity of compound against Streptococcus agalactiae KPB-01 ChEMBL. 14622994
IC50 (functional) = 23 ug ml-1 Inhibitory activity of compound against Staphylococcus aureus ATCC 33591 ChEMBL. 14622994
MIC (functional) = 2 ug ml-1 Antibacterial activity against Vancomycin resistant staphylococcus aureus (VRSA) ChEMBL. 14622994
MIC90 (functional) = 0.008 ug ml-1 Antibacterial activity against Streptococcus pneumoniae ChEMBL. 14622994
MIC90 (functional) = 1 ug ml-1 Antibacterial activity against Methicillin resistant staphylococcus aureus (MRSA) ChEMBL. 14622994
MIC90 (functional) = 8 ug ml-1 Antibacterial activity against Enterococcus species., VanA ChEMBL. 14622994
T1/2 (ADMET) = 7 hr Half life of compound was determined in man with once daily dosing ChEMBL. 14622994

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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