Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0056 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0056 | 0 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0056 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0056 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0056 | 0 | 0.5 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0212 | 0.5254 | 0.5254 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0353 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0056 | 0 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 1 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0056 | 0 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0056 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0353 | 1 | 1 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0212 | 0.5254 | 0.5254 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0353 | 1 | 1 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0212 | 0.5254 | 0.5254 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0353 | 1 | 1 |
Leishmania major | glutaminyl cyclase, putative | 0.0056 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.4449 | 0.4449 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.503 | 0.503 |
Mycobacterium tuberculosis | Conserved protein | 0.0056 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0.5 | Average change in weight is tested in mice at a dose of 16 mg/kg | ChEMBL. | 7381837 |
Activity (functional) | = 3.5 | Average change in weight is tested in mice at a dose of 8 mg/kg | ChEMBL. | 7381837 |
Activity (functional) | = 3.7 | Average change in weight is tested in mice at a dose of 4 mg/kg | ChEMBL. | 7381837 |
Activity (functional) | = 5.3 | Average change in weight is tested in mice at a dose of 2 mg/kg | ChEMBL. | 7381837 |
Ratio (functional) | 0 | Number of mice survived to Number of mice tested on day 5 at a dose of 16 mg/kg; 6/6 | ChEMBL. | 7381837 |
Ratio (functional) | 0 | Number of mice survived to Number of mice tested on day 5 at a dose of 8 mg/kg | ChEMBL. | 7381837 |
Ratio (functional) | 0 | Number of mice survived to Number of mice tested on day 5 at a dose of 4 mg/kg; 6/6 | ChEMBL. | 7381837 |
Ratio (functional) | 0 | Number of mice survived to Number of mice tested on day 5 at a dose of 2 mg/kg; 6/6 | ChEMBL. | 7381837 |
T/C (functional) | = 100 % | Tested on P-388 Leukemia for median survival time treated to median survival time control when administered intrapertoneally at a dose of 4 mg/kg | ChEMBL. | 7381837 |
T/C (functional) | = 100 % | Tested on P-388 Leukemia for median survival time treated to median survival time control when administered intrapertoneally at a dose of 2 mg/kg | ChEMBL. | 7381837 |
T/C (functional) | = 100 % | Tested on P-388 Leukemia for median survival time treated to median survival time control when administered intrapertoneally at a dose of 4 mg/kg | ChEMBL. | 7381837 |
T/C (functional) | = 100 % | Tested on P-388 Leukemia for median survival time treated to median survival time control when administered intrapertoneally at a dose of 2 mg/kg | ChEMBL. | 7381837 |
T/C (functional) | = 106 % | Tested on P-388 Leukemia for median survival time treated to median survival time control when administered intrapertoneally at a dose of 8 mg/kg | ChEMBL. | 7381837 |
T/C (functional) | = 106 % | Tested on P-388 Leukemia for median survival time treated to median survival time control when administered intrapertoneally at a dose of 8 mg/kg | ChEMBL. | 7381837 |
T/C (functional) | = 139 % | Tested on P-388 Leukemia for median survival time treated to median survival time control when administered intrapertoneally at a dose of 16 mg/kg | ChEMBL. | 7381837 |
T/C (functional) | = 139 % | Tested on P-388 Leukemia for median survival time treated to median survival time control when administered intrapertoneally at a dose of 16 mg/kg | ChEMBL. | 7381837 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.