Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | glutaminyl cyclase, putative | 0.004 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.004 | 0 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0249 | 0.2692 | 1 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0249 | 0.2692 | 0.2692 |
Toxoplasma gondii | peptidase, M28 family protein | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.0693 | 0.0693 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.004 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.0693 | 0.2575 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0093 | 0.0693 | 0.2575 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.0693 | 0.2575 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0249 | 0.2692 | 1 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.004 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.0693 | 0.2575 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0169 | 0.1662 | 0.6176 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.0098 | 0.0747 | 0.2774 | |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0169 | 0.1662 | 0.1662 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0169 | 0.1662 | 0.6176 |
Echinococcus granulosus | geminin | 0.0175 | 0.1749 | 0.6499 |
Loa Loa (eye worm) | mechanosensory abnormality protein 6 | 0.0146 | 0.1376 | 0.511 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.1749 | 0.6499 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0249 | 0.2692 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.2692 | 1 |
Brugia malayi | Peptidase family M28 containing protein | 0.0249 | 0.2692 | 1 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0169 | 0.1662 | 0.1662 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.004 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0145 | 0.136 | 0.5052 |
Leishmania major | glutaminyl cyclase, putative | 0.004 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0093 | 0.0693 | 0.2575 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.1749 | 0.6499 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0169 | 0.1662 | 0.6176 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.0693 | 0.2575 |
Echinococcus multilocularis | geminin | 0.0175 | 0.1749 | 0.1749 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.0693 | 0.2575 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.004 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0145 | 0.136 | 0.5052 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.0693 | 0.0693 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.004 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 513 ug hr ml-1 | Area under the curve measured after intravenous bolus administration of 50 mg/kg of compound to rats | ChEMBL. | 14584952 |
CL (ADMET) | = 97.8 ml hr-1 kg-1 | Clearance measured after intravenous bolus administration of 50 mg/kg of compound to rats | ChEMBL. | 14584952 |
Cmax (ADMET) | = 29.3 ug ml-1 | Maximum plasma concentration measured after intravenous bolus administration of 50 mg/kg of compound to rats | ChEMBL. | 14584952 |
Solubility | = 120 mg ml-1 | Solubility of the compound was measured in saline at 25 degree C | ChEMBL. | 14584952 |
Survival (functional) | = 100 % | Anti-microbial activity against Staphylococcus aureus measured as percent survival of mice 1 hr post challenge | ChEMBL. | 14584952 |
Survival (functional) | = 100 % | Anti-microbial activity against Staphylococcus aureus measured as percent survival of mice 1 hr post challenge | ChEMBL. | 14584952 |
T1/2 (ADMET) | = 12.37 hr | Circulatory half life measured after intravenous bolus administration of 50 mg/kg of compound to rats | ChEMBL. | 14584952 |
T1/2 (ADMET) | = 20 hr | Half-life of the compound was determined in rat plasma | ChEMBL. | 14584952 |
T1/2 (ADMET) | > 24 hr | Half-life of the compound was determined in human plasma | ChEMBL. | 14584952 |
Vss (ADMET) | = 3598 ml kg-1 | Volume of distribution at a steady state measured after intravenous bolus administration of 50 mg/kg of compound to rats | ChEMBL. | 14584952 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.