Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0093 | 0 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0582 | 0.6798 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0093 | 0 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0093 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0093 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0582 | 0.6798 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0093 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0582 | 0.6798 | 1 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0093 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0093 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0093 | 0 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0582 | 0.6798 | 0.6798 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0582 | 0.6798 | 1 |
Brugia malayi | Peptidase family M28 containing protein | 0.0582 | 0.6798 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0093 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0093 | 0 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0093 | 0 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0093 | 0 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0093 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3 uM | Compound was evaluated for the inhibition of RANTES-induced migration of human monocytes | ChEMBL. | 11140734 |
IC50 (functional) | = 9.1 uM | Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants | ChEMBL. | 11140734 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.