Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0092 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0577 | 0.8913 | 1 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0092 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0577 | 0.8913 | 1 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0577 | 0.8913 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0092 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0092 | 0 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0092 | 0 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0092 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0092 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0092 | 0 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0092 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0092 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0092 | 0 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0092 | 0 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0577 | 0.8913 | 0.8913 |
Brugia malayi | Peptidase family M28 containing protein | 0.0577 | 0.8913 | 1 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0577 | 0.8913 | 0.8913 |
Toxoplasma gondii | hypothetical protein | 0.0092 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0092 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0092 | 0 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0636 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 282 nM | Binding affinity of the compound for opioid receptor type, human Opioid receptor kappa 1 expressed in membrane homogenates of COS-1 or CHO cells | ChEMBL. | 12431062 |
Ki (binding) | = 368 nM | Binding affinity of the compound for opioid receptor type, human Opioid receptor mu 1 expressed in membrane homogenates of COS-1 or CHO cells | ChEMBL. | 12431062 |
Ki (binding) | = 1700 nM | Binding affinity of the compound for opioid receptor like type, human Opioid receptor like 1 expressed in membrane homogenates of COS-1 or CHO cells | ChEMBL. | 12431062 |
Ki (binding) | = 2340 nM | Binding affinity of the compound for opioid receptor type, human Opioid receptor delta 1 expressed in membrane homogenates of COS-1 or CHO cells | ChEMBL. | 12431062 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.