Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Cathepsin L homolog | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0246 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0246 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0246 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0246 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0246 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0246 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0246 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0246 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0187 | 0.4945 | 0.4945 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.4945 | 0.2587 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0166 | 0.3182 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0246 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0246 | 1 | 0.5 |
Onchocerca volvulus | Cathepsin F homolog | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0246 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0187 | 0.4945 | 0.4945 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0246 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0246 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0246 | 1 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0246 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0166 | 0.3182 | 0.3182 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0246 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0246 | 1 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0246 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0166 | 0.3182 | 0.3182 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0246 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0246 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0246 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0187 | 0.4945 | 0.4945 |
Toxoplasma gondii | cathepsin CPL | 0.0246 | 1 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0246 | 1 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0166 | 0.3182 | 0.3182 |
Plasmodium vivax | vivapain-2 | 0.0246 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0246 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0166 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0246 | 1 | 1 |
Onchocerca volvulus | 0.0246 | 1 | 1 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0246 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0246 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0246 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0246 | 1 | 1 |
Onchocerca volvulus | 0.0246 | 1 | 1 | |
Loa Loa (eye worm) | ctsf protein | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0246 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0246 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0246 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0246 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0187 | 0.4945 | 0.4945 |
Onchocerca volvulus | 0.0246 | 1 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0187 | 0.4945 | 0.4945 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0246 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0246 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0187 | 0.4945 | 0.4945 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0187 | 0.4945 | 0.4945 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0246 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0166 | 0.3182 | 0.3182 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0246 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0246 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0246 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0246 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0246 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0246 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0246 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0166 | 0.3182 | 0.3182 |
Echinococcus multilocularis | cysteine protease | 0.0246 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0246 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0166 | 0.3182 | 0.3182 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0246 | 1 | 1 |
Onchocerca volvulus | 0.0246 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0246 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0246 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0187 | 0.4945 | 0.4945 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0246 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0246 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0246 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0166 | 0.3182 | 0.3182 |
Onchocerca volvulus | 0.0246 | 1 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0246 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0246 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0246 | 1 | 1 |
Onchocerca volvulus | 0.0246 | 1 | 1 | |
Onchocerca volvulus | 0.0246 | 1 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0246 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0187 | 0.4945 | 0.4945 |
Leishmania major | cathepsin L-like protease | 0.0246 | 1 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0187 | 0.4945 | 0.4945 |
Leishmania major | cathepsin L-like protease | 0.0246 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0246 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0166 | 0.3182 | 0.3182 |
Loa Loa (eye worm) | fibroinase | 0.0246 | 1 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0246 | 1 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0246 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0246 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Baseline (functional) | = 181 % | Activated partial thromboplastin time at 30 min following intravenous administration of the compound in rats at a dose 8 mg/kg | ChEMBL. | 8126702 |
Baseline (functional) | = 187 % | Activated partial thromboplastin time at 60 min following intravenous administration of the compound in rats at a dose 8 mg/kg | ChEMBL. | 8126702 |
Baseline (functional) | = 200 % | Activated partial thromboplastin time at 15 min following intravenous administration of the compound in rats at a dose 8 mg/kg | ChEMBL. | 8126702 |
Baseline (functional) | = 217 % | Activated partial thromboplastin time at 5 min following intravenous administration of the compound in rats at a dose 8 mg/kg | ChEMBL. | 8126702 |
Baseline (functional) | = 225 % | Activated partial thromboplastin time at 3 min following intravenous administration of the compound in rats at a dose 8 mg/kg | ChEMBL. | 8126702 |
Baseline (functional) | = 252 % | Activated partial thromboplastin time at 1.5 min following intravenous administration of the compound in rats at a dose 8 mg/kg | ChEMBL. | 8126702 |
Ctt2 (functional) | = 2.8 uM | Concentration that doubles thrombin time (inhibition of fibrin clot) in rats | ChEMBL. | 8126702 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.