Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein, conserved | 0.0163 | 0.0834 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.009 | 0.0386 | 0.0424 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0327 | 0.0346 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0171 | 0.0881 | 0.0881 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0081 | 0.0327 | 0.0351 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0081 | 0.0327 | 0.0315 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0081 | 0.0327 | 0.0315 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0936 | 0.5585 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0171 | 0.0881 | 0.0881 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0171 | 0.0881 | 0.1336 |
Brugia malayi | steroid hormone receptor | 0.0171 | 0.0881 | 0.0933 |
Schistosoma mansoni | thyroid hormone receptor | 0.0171 | 0.0881 | 0.1336 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0327 | 0.0346 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0171 | 0.0881 | 0.1488 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0936 | 0.5585 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0171 | 0.0881 | 0.1336 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0171 | 0.0881 | 0.1488 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0171 | 0.0881 | 0.0933 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0122 | 0.0579 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0081 | 0.0327 | 0.0346 |
Brugia malayi | conserved hypotetical protein | 0.0081 | 0.0327 | 0.0346 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0171 | 0.0881 | 0.1336 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0122 | 0.0579 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0881 | 0.0933 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0795 | 0.4716 | 0.9353 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0327 | 0.0346 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0171 | 0.0881 | 0.0933 |
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0122 | 0.0579 | 0.6909 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0171 | 0.0881 | 0.1336 |
Schistosoma mansoni | nuclear hormone receptor | 0.0081 | 0.0327 | 0.0315 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.009 | 0.0386 | 0.0424 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0081 | 0.0327 | 0.0346 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0081 | 0.0327 | 0.0315 |
Loa Loa (eye worm) | DR-78 | 0.0081 | 0.0327 | 0.0346 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0171 | 0.0881 | 0.0933 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0163 | 0.0834 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0171 | 0.0881 | 0.0933 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0171 | 0.0881 | 0.1488 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0171 | 0.0881 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0881 | 0.0933 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0171 | 0.0881 | 0.1336 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0881 | 0.0933 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0163 | 0.0834 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0171 | 0.0881 | 0.1488 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0122 | 0.0579 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0386 | 0.0409 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0327 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0386 | 0.0409 |
Loa Loa (eye worm) | hypothetical protein | 0.1484 | 0.8951 | 0.9476 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0171 | 0.0881 | 0.1336 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0327 | 0.0346 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0171 | 0.0881 | 0.1336 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0171 | 0.0881 | 0.1336 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0533 | 0.3105 | 0.5431 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0386 | 0.0409 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0171 | 0.0881 | 0.0933 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0081 | 0.0327 | 0.0327 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0171 | 0.0881 | 0.0933 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.009 | 0.0386 | 0.0409 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0795 | 0.4716 | 0.8398 |
Schistosoma mansoni | zinc finger protein | 0.0081 | 0.0327 | 0.0315 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0171 | 0.0881 | 0.0933 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0171 | 0.0881 | 0.0933 |
Brugia malayi | nuclear receptor RXR | 0.0081 | 0.0327 | 0.0346 |
Echinococcus granulosus | FTZ F1 alpha | 0.0171 | 0.0881 | 0.1336 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0327 | 0.0346 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0171 | 0.0881 | 0.1336 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0327 | 0.0346 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.0163 | 0.0834 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0081 | 0.0327 | 0.0351 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0171 | 0.0881 | 0.0933 |
Giardia lamblia | Rrm3p helicase | 0.0163 | 0.0834 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0171 | 0.0881 | 0.1336 |
Echinococcus granulosus | leucine aminopeptidase protein | 0.0122 | 0.0579 | 0.0779 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF6, putative | 0.0163 | 0.0834 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0081 | 0.0327 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0881 | 0.0933 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0156 | 0.0165 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0081 | 0.0327 | 0.0346 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0171 | 0.0881 | 0.0933 |
Schistosoma mansoni | nuclear hormone receptor | 0.0171 | 0.0881 | 0.1336 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0081 | 0.0327 | 0.0346 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0081 | 0.0327 | 0.0315 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.009 | 0.0386 | 0.0424 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0156 | 0.0165 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.1565 | 0.9446 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0884 | 0.5266 | 0.9413 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0122 | 0.0579 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0171 | 0.0881 | 0.0933 |
Schistosoma mansoni | nuclear receptor | 0.0081 | 0.0327 | 0.0315 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0171 | 0.0881 | 0.1488 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0171 | 0.0881 | 0.1336 |
Schistosoma mansoni | nuclear receptor | 0.0081 | 0.0327 | 0.0315 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0081 | 0.0327 | 0.0327 |
Echinococcus multilocularis | leucine aminopeptidase protein | 0.0122 | 0.0579 | 0.0868 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0171 | 0.0881 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0881 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0327 | 0.0346 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0171 | 0.0881 | 0.0933 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0533 | 0.3105 | 0.6048 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0327 | 0.0346 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.009 | 0.0386 | 0.0409 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0163 | 0.0834 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0163 | 0.0834 | 0.139 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0.0447 | 0.5302 |
Brugia malayi | tailless protein | 0.0081 | 0.0327 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0386 | 0.0409 |
Schistosoma mansoni | hypothetical protein | 0.0163 | 0.0834 | 0.1248 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0447 | 0.0535 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0081 | 0.0327 | 0.0351 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0881 | 0.0933 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0171 | 0.0881 | 0.0933 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0171 | 0.0881 | 0.1336 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0533 | 0.3105 | 0.6048 |
Brugia malayi | nuclear hormone receptor | 0.1565 | 0.9446 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0171 | 0.0881 | 0.1488 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0081 | 0.0327 | 0.0315 |
Schistosoma mansoni | nuclear hormone receptor | 0.0081 | 0.0327 | 0.0315 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0122 | 0.0579 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.009 | 0.0386 | 0.0409 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0081 | 0.0327 | 0.0351 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0881 | 0.0933 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0171 | 0.0881 | 0.0933 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0081 | 0.0327 | 0.0351 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0163 | 0.0834 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0171 | 0.0881 | 0.1336 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0081 | 0.0327 | 0.0346 |
Brugia malayi | nuclear receptor RXR | 0.009 | 0.0386 | 0.0409 |
Brugia malayi | ecdysone receptor | 0.0081 | 0.0327 | 0.0346 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0081 | 0.0327 | 0.0346 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0171 | 0.0881 | 0.0933 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0171 | 0.0881 | 0.1336 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0163 | 0.0834 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0846 | 0.5031 | 1 |
Brugia malayi | hypothetical protein | 0.0081 | 0.0327 | 0.0346 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0795 | 0.4716 | 0.8398 |
Brugia malayi | ecdysteroid receptor | 0.0171 | 0.0881 | 0.0933 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0081 | 0.0327 | 0.0315 |
Onchocerca volvulus | 0.0171 | 0.0881 | 0.0881 | |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0081 | 0.0327 | 0.0315 |
Onchocerca volvulus | 0.0081 | 0.0327 | 0.0327 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0171 | 0.0881 | 0.1488 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0163 | 0.0834 | 1 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.0163 | 0.0834 | 1 |
Brugia malayi | hypothetical protein | 0.009 | 0.0386 | 0.0409 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0881 | 0.0933 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0081 | 0.0327 | 0.0346 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0171 | 0.0881 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0327 | 0.0346 |
Onchocerca volvulus | 0.0081 | 0.0327 | 0.0327 | |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0122 | 0.0579 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0171 | 0.0881 | 0.1336 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0171 | 0.0881 | 0.1336 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0081 | 0.0327 | 0.0315 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0122 | 0.0579 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0171 | 0.0881 | 0.0933 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0171 | 0.0881 | 0.0933 |
Echinococcus granulosus | neuropeptide s receptor | 0.0533 | 0.3105 | 0.5431 |
Brugia malayi | nuclear hormone receptor | 0.0171 | 0.0881 | 0.0933 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0171 | 0.0881 | 0.0933 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0122 | 0.0579 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0386 | 0.0409 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0171 | 0.0881 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0327 | 0.0346 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.009 | 0.0386 | 0.0473 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0171 | 0.0881 | 0.0933 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0163 | 0.0834 | 0.1248 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0122 | 0.0579 | 0.6946 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0171 | 0.0881 | 0.0933 |
Brugia malayi | hypothetical protein | 0.0081 | 0.0327 | 0.0346 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0081 | 0.0327 | 0.0346 |
Brugia malayi | hypothetical protein | 0.009 | 0.0386 | 0.0409 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0171 | 0.0881 | 0.1488 |
Schistosoma mansoni | thyroid hormone receptor | 0.0171 | 0.0881 | 0.1336 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0327 | 0.0346 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0171 | 0.0881 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0327 | 0.0346 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0081 | 0.0327 | 0.0346 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0171 | 0.0881 | 0.1488 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 95 nM | Compound was evaluated for its ability to inhibit HIV-1 Reverse Transcriptase in an in vitro enzyme assay | ChEMBL. | 11378361 |
IC50 (binding) | = 1940 nM | Compound was evaluated for its ability to inhibit HIV-1 Reverse Transcriptase in an in vitro enzyme assay | ChEMBL. | 11378361 |
IC90 (functional) | = 0 nM | Compound was evaluated for its ability to inhibit a virus containing the clinically relevant K103N mutation | ChEMBL. | 11378361 |
IC90 (functional) | = 5.2 nM | Compound was evaluated for its ability to inhibit the wild type RF strain of HIV-1 | ChEMBL. | 11378361 |
IC90 (functional) | = 189.4 nM | Compound was evaluated for its ability to inhibit the wild type RF strain of HIV-1 | ChEMBL. | 11378361 |
IC90 (functional) | = 333 nM | Compound was evaluated for its ability to inhibit a virus containing the clinically relevant K103N mutation | ChEMBL. | 11378361 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.