Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 protease | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | Get druggable targets OG5_131408 | All targets in OG5_131408 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0709 | 0.3453 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0709 | 0.3453 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.0709 | 0.3453 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0709 | 0.3453 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0709 | 0.3453 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0709 | 0.3453 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0709 | 0.3453 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0709 | 0.3453 | 0.3453 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0709 | 0.3453 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0709 | 0.3453 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0709 | 0.3453 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0709 | 0.3453 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0709 | 0.3453 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0709 | 0.3453 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0709 | 0.3453 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0709 | 0.3453 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0709 | 0.3453 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0709 | 0.3453 | 0.3453 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0709 | 0.3453 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0709 | 0.3453 | 0.5 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0709 | 0.3453 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0709 | 0.3453 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0709 | 0.3453 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0709 | 0.3453 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.