TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 475.798 | Formula: C23H21Cl3N4O
H donors: 1 H acceptors: 2 LogP: 6.49 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(c(c1)Cl)n1nc(c2c1c1cc(C)c(cc1C2)Cl)C(=O)NN1CCCCC1
InChi: 1S/C23H21Cl3N4O/c1-13-9-16-14(11-18(13)25)10-17-21(23(31)28-29-7-3-2-4-8-29)27-30(22(16)17)20-6-5-15(24)12-19(20)26/h5-6,9,11-12H,2-4,7-8,10H2,1H3,(H,28,31)
InChiKey: VJYDWIGYSWSNCJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	cannabinoid receptor 2 (macrophage)	Starlite/ChEMBL	References
Mus musculus	cannabinoid receptor 1 (brain)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0307	0.4833	1
Leishmania major	glucose transporter, lmgt3	0.0033	0.0329	0.8107
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0322	0.0607
Schistosoma mansoni	acetylcholine receptor-related	0.0142	0.2113	0.4335
Echinococcus multilocularis	flap endonuclease 1	0.0028	0.0246	0.0448
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0176	1
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0329	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2113	0.2113
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0231	0.0424
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.087	0.1748
Loa Loa (eye worm)	hypothetical protein	0.0307	0.4833	0.4833
Schistosoma mansoni	nAChR subunit	0.0307	0.4833	1
Loa Loa (eye worm)	GABA receptor subunit	0.0165	0.2504	0.2504
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0323	0.0404
Entamoeba histolytica	protein kinase, putative	0.0033	0.0322	0.0628
Loa Loa (eye worm)	hypothetical protein	0.0165	0.2504	0.2504
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0307	0.4833	1
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.087	0.1748
Brugia malayi	hypothetical protein	0.0039	0.0422	0.052
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0176	0.0961
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0323	0.0404
Leishmania major	hypothetical protein, conserved	0.0027	0.0231	0.544
Loa Loa (eye worm)	hypothetical protein	0.0165	0.2504	0.2504
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0307	0.4833	1
Echinococcus granulosus	General substrate transporter	0.0092	0.1296	0.2635
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0307	0.4833	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0307	0.4833	0.6371
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0307	0.4833	1
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2113	0.2113
Brugia malayi	hypothetical protein	0.0142	0.2113	0.2762
Brugia malayi	Cam kinase protein 1	0.0033	0.0322	0.0387
Echinococcus multilocularis	nAChR subunit	0.0307	0.4833	1
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0142	0.2113	0.2762
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0142	0.2113	0.2762
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0176	0.395
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0323	0.0404
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0399	1
Trypanosoma brucei	glucose transporter 1E	0.0033	0.0329	0.8107
Echinococcus granulosus	glycine receptor subunit beta	0.0307	0.4833	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0329	0.8107
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0329	0.8107
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.1544	0.315
Schistosoma mansoni	protein kinase	0.0033	0.0322	0.0607
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0142	0.2113	0.4335
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0399	1
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0028	0.0246	0.5843
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0311	0.1855
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0322	0.0322
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0107	0.1544	0.315
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0307	0.4833	1
Leishmania major	protein kinase, putative	0.0033	0.0322	0.7919
Entamoeba histolytica	hypothetical protein	0.0165	0.2504	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0323	0.0617
Trypanosoma brucei	glucose transporter 2A	0.0033	0.0329	0.8107
Plasmodium vivax	flap endonuclease 1, putative	0.0028	0.0246	0.0298
Brugia malayi	Cytochrome P450 family protein	0.0027	0.0232	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2113	0.2113
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2113	0.2113
Loa Loa (eye worm)	hypothetical protein	0.0165	0.2504	0.2504
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0176	0.0303
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.0289	0.0538
Onchocerca volvulus		0.0165	0.2504	0.5149
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.1544	0.315
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0307	0.4833	0.6371
Loa Loa (eye worm)	hypothetical protein	0.0165	0.2504	0.2504
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2113	0.2113
Entamoeba histolytica	Flap nuclease, putative	0.0028	0.0246	0.0299
Echinococcus multilocularis	glycine receptor subunit beta	0.0307	0.4833	1
Loa Loa (eye worm)	ACC-1 protein	0.0307	0.4833	0.4833
Brugia malayi	excitatory GABA receptor EXP-1A	0.0307	0.4833	0.6371
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0329	0.8107
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0142	0.2113	0.2762
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2113	0.2113
Trypanosoma cruzi	hexose transporter	0.0033	0.0329	0.8107
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0142	0.2113	0.2113
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0422	0.0815
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.087	0.1748
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0028	0.0246	0.0455
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0165	0.2504	0.3281
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0329	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0165	0.2504	0.2504
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.087	0.1748
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0322	0.0607
Loa Loa (eye worm)	sugar transporter	0.0107	0.1544	0.1544
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0307	0.4833	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0329	0.8107
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0176	0.0201
Schistosoma mansoni	flap endonuclease-1	0.0025	0.0201	0.0355
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0142	0.2113	0.2762
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0329	0.8107
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0307	0.4833	1
Schistosoma mansoni	nAChR subunit	0.0307	0.4833	1
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0176	0.3046
Echinococcus granulosus	nAChR subunit	0.0307	0.4833	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0307	0.4833	0.6371
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0473	0.7569	1
Schistosoma mansoni	nAChR subunit	0.0307	0.4833	1
Schistosoma mansoni	hypothetical protein	0.0039	0.0422	0.0815
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0176	0.0193
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0422	0.0815
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0231	0.0277
Schistosoma mansoni	nAChR subunit	0.0307	0.4833	1
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.087	0.1114
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0329	0.8107
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0307	0.4833	1
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0307	0.4833	1
Brugia malayi	hypothetical protein	0.0027	0.0231	0.0266
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0307	0.4833	0.4833
Brugia malayi	Cation transporter family protein	0.0307	0.4833	0.6371
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0117	1
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0329	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0322	0.0387
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0322	0.1927
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2113	0.2113
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0307	0.4833	1
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0329	0.1973
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0176	0.0201
Brugia malayi	Sugar transporter family protein	0.0107	0.1544	0.2007
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0165	0.2504	0.3281
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0307	0.4833	0.4833
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0307	0.4833	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0031	0.0031
Schistosoma mansoni	protein kinase	0.0033	0.0322	0.0607
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0142	0.2113	0.4335
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0323	0.0404
Toxoplasma gondii	protein kinase, putative	0.0302	0.4757	1
Onchocerca volvulus		0.0307	0.4833	1
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2113	0.2113
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0323	0.0617
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.087	0.1748
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0307	0.4833	1
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2113	0.2113
Loa Loa (eye worm)	hypothetical protein	0.0307	0.4833	0.4833
Loa Loa (eye worm)	hypothetical protein	0.0165	0.2504	0.2504
Brugia malayi	hypothetical protein	0.0142	0.2113	0.2762
Leishmania major	glucose transporter, lmgt1	0.0033	0.0329	0.8107
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0323	0.0404
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0399	1
Brugia malayi	hypothetical protein	0.0142	0.2113	0.2762
Onchocerca volvulus		0.0307	0.4833	1
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0311	0.0584
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0176	0.5182
Echinococcus multilocularis	glycine receptor subunit beta	0.0307	0.4833	1
Loa Loa (eye worm)	hypothetical protein	0.0307	0.4833	0.4833
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0307	0.4833	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0329	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0173	0.2628	0.3595
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Loa Loa (eye worm)	ACC-1 protein	0.0307	0.4833	0.4833
Schistosoma mansoni	nAChR subunit	0.0307	0.4833	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0311	0.0584
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0329	0.8107
Schistosoma mansoni	glucose transport protein	0.0107	0.1544	0.315
Schistosoma mansoni	protein kinase	0.0033	0.0322	0.0607
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0323	0.0404
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0176	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.1544	0.315
Loa Loa (eye worm)	hypothetical protein	0.0165	0.2504	0.2504
Echinococcus granulosus	nAChR subunit	0.0165	0.2504	0.5149
Loa Loa (eye worm)	hypothetical protein	0.0307	0.4833	0.4833
Schistosoma mansoni	neurotransmitter gated ion channel	0.0142	0.2113	0.4335
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0165	0.2504	0.5149
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0231	0.544
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0231	0.544
Echinococcus granulosus	flap endonuclease 1	0.0028	0.0246	0.0448
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0307	0.4833	0.6371
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0311	0.0372
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0176	0.5
Loa Loa (eye worm)	hypothetical protein	0.0307	0.4833	0.4833
Loa Loa (eye worm)	hypothetical protein	0.0307	0.4833	0.4833
Brugia malayi	hypothetical protein	0.0018	0.0072	0.0055
Brugia malayi	Cation transporter family protein	0.0307	0.4833	0.6371
Onchocerca volvulus		0.0307	0.4833	1
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0176	0.0303
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0307	0.4833	0.6371
Leishmania major	glucose transporter, lmgt2	0.0033	0.0329	0.8107
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.1544	0.315
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2113	0.2113
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0311	1
Loa Loa (eye worm)	hypothetical protein	0.0307	0.4833	0.4833
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0082	0.1383
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0399	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0231	0.0277
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0307	0.4833	1
Loa Loa (eye worm)	hypothetical protein	0.0307	0.4833	0.4833
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0165	0.2504	0.5149
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0173	0.2628	0.3595
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0307	0.4833	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0173	0.2628	0.5495
Plasmodium falciparum	protein kinase 7	0.0302	0.4757	0.6542
Echinococcus multilocularis	nAChR subunit	0.0165	0.2504	0.5149
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0307	0.4833	0.6371
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0323	0.0404
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0399	0.051
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0322	0.0607
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0322	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0329	0.1973
Onchocerca volvulus		0.0165	0.2504	0.5149
Onchocerca volvulus		0.0142	0.2113	0.4335
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.0329	0.8107
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0322	0.0607
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0307	0.4833	0.4833
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0311	0.0584
Schistosoma mansoni	glucose transport protein	0.0107	0.1544	0.315
Loa Loa (eye worm)	hypothetical protein	0.0473	0.7569	0.7569
Brugia malayi	Cation transporter family protein	0.0307	0.4833	0.6371
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0422	0.0815
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0322	0.0607
Entamoeba histolytica	hypothetical protein	0.0039	0.0422	0.1058
Loa Loa (eye worm)	hypothetical protein	0.0307	0.4833	0.4833
Schistosoma mansoni	nAChR subunit	0.0307	0.4833	1
Giardia lamblia	Flap structure-specific endonuclease	0.0028	0.0246	0.7665
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0.0232	0.0232
Onchocerca volvulus		0.0307	0.4833	1
Schistosoma mansoni	nAChR subunit	0.0142	0.2113	0.4335
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0307	0.4833	1
Entamoeba histolytica	protein kinase, putative	0.0033	0.0322	0.0628
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0307	0.4833	0.6371
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0311	0.0581
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0307	0.4833	1
Loa Loa (eye worm)	sugar transporter	0.0015	0.0031	0.0031
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0307	0.4833	0.4833
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0231	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0212	0.0212
Schistosoma mansoni	hypothetical protein	0.0107	0.1544	0.315
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0322	0.0322
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0322	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0176	0.0308
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0031	0.0031
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0329	0.8107
Entamoeba histolytica	hypothetical protein	0.0039	0.0422	0.1058
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0231	0.0231
Brugia malayi	hypothetical protein	0.0142	0.2113	0.2762
Brugia malayi	hypothetical protein	0.0142	0.2113	0.2762
Loa Loa (eye worm)	hypothetical protein	0.0307	0.4833	0.4833
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0322	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0142	0.2113	0.4335
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0322	0.0607
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0322	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0307	0.4833	0.4833
Echinococcus multilocularis	General substrate transporter	0.0092	0.1296	0.2635
Schistosoma mansoni	glucose transport protein	0.0107	0.1544	0.315
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Brugia malayi	RNA binding protein	0.0066	0.087	0.1114
Loa Loa (eye worm)	hypothetical protein	0.0307	0.4833	0.4833
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0307	0.4833	0.6371
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0323	0.0404
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0311	1
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2113	0.2113
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0307	0.4833	0.6371
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0399	0.051
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0307	0.4833	0.6371
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0307	0.4833	0.4833
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0307	0.4833	0.6371
Loa Loa (eye worm)	hypothetical protein	0.0165	0.2504	0.2504
Trichomonas vaginalis	conserved hypothetical protein	0.0107	0.1544	1
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0028	0.0246	0.5843
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0028	0.0246	0.5843
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0307	0.4833	0.4833
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0165	0.2504	0.3281
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0307	0.4833	1
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2113	0.2113
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0329	0.8107
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.1544	0.315
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.087	0.1748
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0307	0.4833	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.1544	0.315
Loa Loa (eye worm)	LGC-31 protein	0.0307	0.4833	0.4833
Plasmodium falciparum	flap endonuclease 1	0.0028	0.0246	0.0298
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0311	0.0584
Loa Loa (eye worm)	RNA binding protein	0.0066	0.087	0.087
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.087	0.087
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0307	0.4833	1
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0142	0.2113	0.4335
Schistosoma mansoni	neurotransmitter gated ion channel	0.0165	0.2504	0.5149
Echinococcus granulosus	tar DNA binding protein	0.0066	0.087	0.1748
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0323	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0176	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Loa Loa (eye worm)	acetylcholine receptor protein	0.0142	0.2113	0.2113
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0329	0.1973
Brugia malayi	TAR-binding protein	0.0066	0.087	0.1114
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0307	0.4833	0.6371
Loa Loa (eye worm)	hypothetical protein	0.0307	0.4833	0.4833
Brugia malayi	Flap endonuclease-1	0.0028	0.0246	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0332	0.5239	0.5239
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0307	0.4833	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0307	0.4833	0.6371
Plasmodium falciparum	hexose transporter	0.0107	0.1544	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0307	0.4833	0.4833
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0142	0.2113	0.2762
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0176	0.0303
Schistosoma mansoni	neurotransmitter gated ion channel	0.0142	0.2113	0.4335
Entamoeba histolytica	hypothetical protein	0.0039	0.0422	0.1058
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0142	0.2113	0.2113
Trichomonas vaginalis	flap endonuclease-1, putative	0.0028	0.0246	0.1422
Schistosoma mansoni	nAChR subunit	0.0142	0.2113	0.4335
Onchocerca volvulus		0.0142	0.2113	0.4335
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0323	0.0404
Loa Loa (eye worm)	flap endonuclease-1	0.0028	0.0246	0.0246
Entamoeba histolytica	hypothetical protein	0.0039	0.0422	0.1058
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0307	0.4833	0.6371
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2113	0.2113
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0031	0.5
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0231	0.544
Onchocerca volvulus		0.0307	0.4833	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0128	0.0641
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0329	0.1973
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.1544	0.315
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.087	0.087
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0322	0.7919
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0142	0.2113	0.4335
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0307	0.4833	1
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.0307	0.4833	0.4833
Plasmodium falciparum	protein kinase 6	0.0454	0.7255	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0142	0.2113	0.4335
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0307	0.4833	0.4833
Onchocerca volvulus	Putative nachr subunit	0.0307	0.4833	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0329	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0311	0.0311
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0176	0.395
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0329	0.1973
Plasmodium vivax	hexose transporter	0.0107	0.1544	0.2094
Onchocerca volvulus		0.0307	0.4833	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0329	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2113	0.2113
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0307	0.4833	1
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0307	0.4833	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0307	0.4833	0.6371
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0399	1
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0454	0.7255	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0176	0.0176
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0142	0.2113	0.2762
Toxoplasma gondii	facilitative glucose transporter GT1	0.0107	0.1544	0.3201
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0399	0.0779
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0307	0.4833	1
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0311	0.0372
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0329	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0307	0.4833	0.4833
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0176	0.395
Onchocerca volvulus		0.0142	0.2113	0.4335
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0165	0.2504	0.3281
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2113	0.2113
Echinococcus granulosus	glycine receptor subunit beta	0.0307	0.4833	1
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.0289	0.0538
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0307	0.4833	1
Schistosoma mansoni	nAChR subunit	0.0307	0.4833	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 85 nM	Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptor	ChEMBL.	17149879
Ki (binding)	= 85 nM	Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptor	ChEMBL.	17149879
Ki (binding)	= 1200 nM	Displacement of [3H]CP-55940 from CD1 mouse brain CB1 receptor	ChEMBL.	17149879
Ki (binding)	= 1200 nM	Displacement of [3H]CP-55940 from CD1 mouse brain CB1 receptor	ChEMBL.	17149879
Ratio Ki (binding)	= 14	Selectivity for CD1 mouse CB2 receptor over CB1 receptor	ChEMBL.	17149879
Ratio Ki (binding)	= 14	Selectivity for CD1 mouse CB2 receptor over CB1 receptor	ChEMBL.	17149879

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL216595

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 409926