Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0203 | 0.4143 | 1 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.02 | 0.401 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Brugia malayi | Cation transporter family protein | 0.0203 | 0.4143 | 1 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0114 | 0.0379 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0203 | 0.4143 | 1 |
Onchocerca volvulus | 0.0114 | 0.0379 | 0.0524 | |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0379 | 0.0914 |
Plasmodium falciparum | topoisomerase I | 0.02 | 0.401 | 0.5 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0114 | 0.0379 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0379 | 0.0914 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0203 | 0.4143 | 1 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0203 | 0.4143 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0203 | 0.4143 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0203 | 0.4143 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0203 | 0.4143 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0203 | 0.4143 | 1 |
Trichomonas vaginalis | cdc25b, putative | 0.0114 | 0.0379 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.017 | 0.0411 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0114 | 0.0379 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.017 | 0.0411 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | LGC-31 protein | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0203 | 0.4143 | 1 |
Onchocerca volvulus | 0.0203 | 0.4143 | 1 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0341 | 1 | 0.5 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0203 | 0.4143 | 1 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0203 | 0.4143 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0203 | 0.4143 | 1 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.017 | 0.0411 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.017 | 0.0411 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0203 | 0.4143 | 1 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0203 | 0.4143 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0203 | 0.4143 | 1 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0114 | 0.0379 | 0.0524 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0114 | 0.0379 | 0.0524 |
Schistosoma mansoni | nAChR subunit | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0203 | 0.4143 | 1 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0203 | 0.4143 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0203 | 0.4143 | 1 |
Plasmodium vivax | topoisomerase I, putative | 0.02 | 0.401 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.017 | 0.0411 |
Onchocerca volvulus | 0.0114 | 0.0379 | 0.0524 | |
Onchocerca volvulus | 0.0114 | 0.0379 | 0.0524 | |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Onchocerca volvulus | 0.0203 | 0.4143 | 1 | |
Loa Loa (eye worm) | ACC-1 protein | 0.0203 | 0.4143 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | ACC-1 protein | 0.0203 | 0.4143 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0203 | 0.4143 | 1 |
Echinococcus multilocularis | nAChR subunit | 0.0203 | 0.4143 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0203 | 0.4143 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0203 | 0.4143 | 1 |
Brugia malayi | DNA topoisomerase I | 0.02 | 0.401 | 0.9665 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0203 | 0.4143 | 1 |
Onchocerca volvulus | Putative nachr subunit | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0203 | 0.4143 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0203 | 0.4143 | 1 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.0114 | 0.0379 | 0.0524 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0203 | 0.4143 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0203 | 0.4143 | 1 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0203 | 0.4143 | 1 |
Brugia malayi | Cation transporter family protein | 0.0203 | 0.4143 | 1 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.02 | 0.401 | 0.9665 |
Onchocerca volvulus | 0.0114 | 0.0379 | 0.0524 | |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0203 | 0.4143 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0203 | 0.4143 | 1 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0114 | 0.0379 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0203 | 0.4143 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0203 | 0.4143 | 1 |
Echinococcus granulosus | nAChR subunit | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0203 | 0.4143 | 1 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0114 | 0.0379 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0203 | 0.4143 | 1 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0114 | 0.0379 | 1 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0203 | 0.4143 | 1 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0203 | 0.4143 | 1 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0149 | 0.1879 | 0.5 |
Onchocerca volvulus | 0.0203 | 0.4143 | 1 | |
Trichomonas vaginalis | cdc25b, putative | 0.0114 | 0.0379 | 0.5 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0114 | 0.0379 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0149 | 0.1879 | 0.4302 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Trichomonas vaginalis | cdc25c, putative | 0.0114 | 0.0379 | 0.5 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0114 | 0.0379 | 0.0524 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0203 | 0.4143 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.02 | 0.401 | 0.9679 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0109 | 0.017 | 0.0411 |
Onchocerca volvulus | 0.0203 | 0.4143 | 1 | |
Brugia malayi | Cation transporter family protein | 0.0203 | 0.4143 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0203 | 0.4143 | 1 |
Onchocerca volvulus | 0.0203 | 0.4143 | 1 | |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0203 | 0.4143 | 1 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0149 | 0.1879 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.017 | 0.0411 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0203 | 0.4143 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0203 | 0.4143 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0203 | 0.4143 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0203 | 0.4143 | 1 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.02 | 0.401 | 0.9665 |
Schistosoma mansoni | DNA topoisomerase type I | 0.02 | 0.401 | 0.9665 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0203 | 0.4143 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0149 | 0.1879 | 0.4302 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.017 | 0.0411 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0203 | 0.4143 | 1 |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.0114 | 0.0379 | 0.0524 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0203 | 0.4143 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0203 | 0.4143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.017 | 0.0411 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0149 | 0.1879 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0203 | 0.4143 | 1 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0114 | 0.0379 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.017 | 0.0411 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0203 | 0.4143 | 1 |
Onchocerca volvulus | 0.0203 | 0.4143 | 1 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0203 | 0.4143 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.