Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 2 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | glutathione S-transferase | 0.0034 | 0.0132 | 0.5 |
Echinococcus multilocularis | glutathione S transferase | 0.0034 | 0.0132 | 1 |
Echinococcus granulosus | prostaglandin H2 D isomerase | 0.0034 | 0.0132 | 0.0132 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | glutathione-S-transferase | 0.0034 | 0.0132 | 1 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Echinococcus multilocularis | prostaglandin H2 D isomerase | 0.0034 | 0.0132 | 1 |
Echinococcus multilocularis | glutathione S transferase | 0.0034 | 0.0132 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | GST class-mu | 0.0034 | 0.0132 | 1 |
Echinococcus granulosus | glutathione S transferase | 0.0034 | 0.0132 | 0.0132 |
Echinococcus granulosus | glutathione s transferase mu | 0.0034 | 0.0132 | 0.0132 |
Schistosoma mansoni | Glutathione S-transferase 28 kDa (GST 28) (GST class-mu) | 0.0034 | 0.0132 | 1 |
Echinococcus multilocularis | glutathione S-transferase | 0.0034 | 0.0132 | 1 |
Brugia malayi | glutathione transferase | 0.0147 | 0.5083 | 1 |
Plasmodium vivax | glutathione S-transferase, putative | 0.0034 | 0.0132 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.5083 | 1 |
Echinococcus multilocularis | glutathione S transferase | 0.0034 | 0.0132 | 1 |
Echinococcus multilocularis | glutathione s transferase mu | 0.0034 | 0.0132 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (functional) | = 90 % | Inhibition of IL1-stimulated IL6 production in HFF cells relative to dexamethasone | ChEMBL. | 17181172 |
Efficacy (functional) | = 90 % | Inhibition of IL1-stimulated IL6 production in HFF cells relative to dexamethasone | ChEMBL. | 17181172 |
IC50 (binding) | = 6 nM | Inhibition of tetramethylrhodamine labeled dexamethosone binding to GR by FP assay | ChEMBL. | 17181172 |
IC50 (functional) | = 6 nM | Inhibition of IL1-stimulated IL6 production in HFF cells | ChEMBL. | 17181172 |
IC50 (binding) | = 6 nM | Inhibition of tetramethylrhodamine labeled dexamethosone binding to GR by FP assay | ChEMBL. | 17181172 |
IC50 (functional) | = 6 nM | Inhibition of IL1-stimulated IL6 production in HFF cells | ChEMBL. | 17181172 |
IC50 (binding) | = 450 nM | Inhibition of tetramethylrhodamine labeled dexamethosone binding to MR by FP assay | ChEMBL. | 17181172 |
IC50 (binding) | = 450 nM | Inhibition of tetramethylrhodamine labeled dexamethosone binding to MR by FP assay | ChEMBL. | 17181172 |
IC50 (binding) | = 555 nM | Inhibition of tetramethylrhodamine labeled RU486 binding to PR by FP assay | ChEMBL. | 17181172 |
IC50 (binding) | = 555 nM | Inhibition of tetramethylrhodamine labeled RU486 binding to PR by FP assay | ChEMBL. | 17181172 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17181172 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.