Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | hydroxysteroid 11-beta dehydrogenase 1 | Starlite/ChEMBL | References |
Homo sapiens | hydroxysteroid (11-beta) dehydrogenase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | short chain dehydrogenase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Mycobacterium tuberculosis | Probable oxidoreductase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid (11-beta) dehydrogenase 1 | 292 aa | 250 aa | 24.8 % |
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid 11-beta dehydrogenase 1 | 292 aa | 246 aa | 25.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | glutathione transferase | 0.0197 | 0.2392 | 0.5 |
Echinococcus multilocularis | glutathione S transferase | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | Glutathione S-transferase 28 kDa (GST 28) (GST class-mu) | 0.0047 | 0 | 0.5 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0676 | 1 | 0.5 |
Schistosoma mansoni | glutathione-S-transferase | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | glutathione S transferase | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | prostaglandin H2 D isomerase | 0.0047 | 0 | 0.5 |
Plasmodium vivax | glutathione S-transferase, putative | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | GST class-mu | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | glutathione S-transferase | 0.0047 | 0 | 0.5 |
Plasmodium falciparum | glutathione S-transferase | 0.0047 | 0 | 0.5 |
Echinococcus granulosus | glutathione S transferase Mu 1 | 0.0383 | 0.5348 | 1 |
Echinococcus multilocularis | glutathione s transferase mu | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | glutathione S transferase | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.2392 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | < 1 L/hr.Kg | Intrinsic clearance in human liver microsomes at 1 uM | ChEMBL. | 17201418 |
CL (ADMET) | < 6 L/hr.Kg | Intrinsic clearance in mouse liver microsomes at 1 uM | ChEMBL. | 17201418 |
IC50 (binding) | = 2100 nM | Inhibition of human 11beta-HSD1 expressed in HEK293 cells by FPIA | ChEMBL. | 17201418 |
IC50 (binding) | = 2100 nM | Inhibition of human 11beta-HSD1 expressed in HEK293 cells by FPIA | ChEMBL. | 17201418 |
Ki (binding) | = 62 nM | Inhibition of human 11beta-HSD1 expressed in E. coli by SPA | ChEMBL. | 17201418 |
Ki (binding) | = 62 nM | Inhibition of human 11beta-HSD1 expressed in E. coli by SPA | ChEMBL. | 17201418 |
Ki (binding) | = 4100 nM | Inhibition of mouse 11beta-HSD1 expressed in E. coli by SPA | ChEMBL. | 17201418 |
Ki (binding) | = 4100 nM | Inhibition of mouse 11beta-HSD1 expressed in E. coli by SPA | ChEMBL. | 17201418 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.