Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | peptide deformylase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0599 | 1 | 0.5 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0599 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0599 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0599 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0599 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0599 | 1 | 0.5 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0599 | 1 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0599 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0279 | 0.3503 | 0.5 |
Mycobacterium ulcerans | proteasome PrcB | 0.0599 | 1 | 1 |
Chlamydia trachomatis | peptide deformylase | 0.0279 | 0.3503 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0599 | 1 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.0279 | 0.3503 | 0.5 |
Echinococcus granulosus | proteasome prosome macropain | 0.0599 | 1 | 0.5 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0599 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0599 | 1 | 0.5 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0599 | 1 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0599 | 1 | 0.5 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0599 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0599 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of human mitochondrial PDF | ChEMBL. | 17201406 | |
IC50 (binding) | 0 | Inhibition of human mitochondrial PDF | ChEMBL. | 17201406 |
IC50 (binding) | = 0.05 uM | Inhibition of PDF1B | ChEMBL. | 17201406 |
IC50 (binding) | = 0.05 uM | Inhibition of PDF1B | ChEMBL. | 17201406 |
IC50 (binding) | = 0.4 uM | Inhibition of PDF2 | ChEMBL. | 17201406 |
IC50 (binding) | = 150 uM | Inhibition of Arabidopsis thaliana mitochondrial PDF1A | ChEMBL. | 17201406 |
IC50 (binding) | = 150 uM | Inhibition of Arabidopsis thaliana mitochondrial PDF1A | ChEMBL. | 17201406 |
MIC (functional) | 0 | Antibacterial activity against Bacillus subtilis | ChEMBL. | 17201406 |
MIC (functional) | 0 | Antibacterial activity against Escherichia coli K37 | ChEMBL. | 17201406 |
MIC (functional) | = 9 ug ml-1 | Antibacterial activity against Bacillus subtilis Y101 | ChEMBL. | 17201406 |
MIC (functional) | = 120 ug ml-1 | Antibacterial activity against Escherichia coli CAG1284 | ChEMBL. | 17201406 |
MIC (functional) | = 120 ug ml-1 | Antibacterial activity against Escherichia coli CAG1284 | ChEMBL. | 17201406 |
MIC (functional) | > 300 ug ml-1 | Antibacterial activity against Escherichia coli JM101Tr | ChEMBL. | 17201406 |
MIC (functional) | > 300 ug ml-1 | Antibacterial activity against Bacillus subtilis 168 | ChEMBL. | 17201406 |
MIC (functional) | > 300 ug ml-1 | Antibacterial activity against Bacillus subtilis D101 | ChEMBL. | 17201406 |
MIC (functional) | > 300 ug ml-1 | Antibacterial activity against Bacillus subtilis MO3482 | ChEMBL. | 17201406 |
MIC (functional) | > 300 ug ml-1 | Antibacterial activity against Escherichia coli JM101Tr | ChEMBL. | 17201406 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.