Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0095 | 0.0448 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0095 | 0.0448 | 1 |
Leishmania major | pentamidine resistance protein 1 | 0.0095 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0448 | 0.0433 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0095 | 0.0448 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0095 | 0.0448 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.0095 | 0.0448 | 0.5 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0095 | 0.0448 | 1 |
Giardia lamblia | ABC transporter, putative | 0.0095 | 0.0448 | 1 |
Trypanosoma brucei | p-glycoprotein | 0.0095 | 0.0448 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0095 | 0.0448 | 1 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0095 | 0.0448 | 1 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0095 | 0.0448 | 0.0433 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0433 | 0.0418 |
Leishmania major | ABC-thiol transporter | 0.0095 | 0.0448 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0095 | 0.0448 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0095 | 0.0448 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0095 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0448 | 0.0433 |
Schistosoma mansoni | multidrug resistance protein | 0.0095 | 0.0448 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.0095 | 0.0448 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0095 | 0.0448 | 1 |
Leishmania major | p-glycoprotein e | 0.0095 | 0.0448 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.0095 | 0.0448 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0566 | 1 | 1 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0095 | 0.0448 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0095 | 0.0448 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0095 | 0.0448 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0095 | 0.0448 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0095 | 0.0448 | 0.5 |
Brugia malayi | multidrug resistance related protein 1 | 0.0095 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0566 | 1 | 1 |
Trypanosoma brucei | multidrug resistance protein E | 0.0095 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0566 | 1 | 1 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0095 | 0.0448 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0566 | 1 | 1 |
Entamoeba histolytica | ABC transporter, putative | 0.0095 | 0.0448 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0095 | 0.0448 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0095 | 0.0448 | 0.5 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0095 | 0.0448 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0095 | 0.0448 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0095 | 0.0448 | 1 |
Giardia lamblia | MRP-like ABC transporter | 0.0095 | 0.0448 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Dose (functional) | > 1 mg kg-1 | Evaluated for 50% increase of myocardial contractility in anesthetized dog, administered intravenously | ChEMBL. | 2864447 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.