Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | olfactory channel protein osm-9 | 0.0067 | 0.2641 | 0.057 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0063 | 0.2196 | 0.2005 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0063 | 0.2196 | 1 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0067 | 0.2641 | 0.2484 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.2196 | 0.5 | |
Echinococcus granulosus | shaker cognate | 0.0063 | 0.2196 | 0.2005 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0063 | 0.2196 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | potassium large conductance calcium activated | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | potassium voltage gated channel subfamily C | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0063 | 0.2196 | 0.2005 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0067 | 0.2641 | 0.057 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0063 | 0.2196 | 1 |
Echinococcus granulosus | calcium activated potassium channel | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | two pore calcium channel protein 2 | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0063 | 0.2196 | 0.2005 |
Onchocerca volvulus | Transient receptor potential cation channel trpm homolog | 0.0063 | 0.2196 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0063 | 0.2196 | 0.2005 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0043 | 0.0335 | 0.5 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0063 | 0.2196 | 0.2005 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0063 | 0.2196 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0063 | 0.2196 | 0.2005 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0146 | 1 | 1 |
Leishmania major | hypothetical protein, unknown function | 0.0063 | 0.2196 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0139 | 0.9346 | 0.9162 |
Leishmania major | hypothetical protein, conserved | 0.0063 | 0.2196 | 0.5 |
Echinococcus granulosus | voltage gated hydrogen channel 1 | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | potassium voltage gated channel subfamily D | 0.0063 | 0.2196 | 0.2005 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0067 | 0.2641 | 0.057 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0063 | 0.2196 | 1 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0063 | 0.2196 | 0.2005 |
Schistosoma mansoni | transient receptor potential channel | 0.0067 | 0.2641 | 0.057 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0063 | 0.2196 | 0.2005 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0063 | 0.2196 | 1 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0063 | 0.2196 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0063 | 0.2196 | 0.2005 |
Toxoplasma gondii | hypothetical protein | 0.0063 | 0.2196 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0063 | 0.2196 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0063 | 0.2196 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | potassium voltage gated channel subfamily D | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0063 | 0.2196 | 0.2005 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0067 | 0.2641 | 0.2484 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | sodium leak channel non selective protein | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0063 | 0.2196 | 0.2005 |
Trypanosoma brucei | RNA helicase, putative | 0.0139 | 0.9346 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | Potassium voltage gated channel protein Shaw | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0063 | 0.2196 | 0.2005 |
Loa Loa (eye worm) | acetyltransferase | 0.0146 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily D | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.0063 | 0.2196 | 0.2005 |
Onchocerca volvulus | Transient receptor potential cation channel trpm homolog | 0.0063 | 0.2196 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0142 | 0.9616 | 1 |
Echinococcus granulosus | two pore calcium channel protein 1 | 0.0063 | 0.2196 | 0.2005 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0063 | 0.2196 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2641 | 0.057 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0146 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0063 | 0.2196 | 0.2005 |
Echinococcus granulosus | sodium channel protein | 0.0063 | 0.2196 | 0.2005 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0063 | 0.2196 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0063 | 0.2196 | 0.2005 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0067 | 0.2641 | 0.057 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug uptake (ADMET) | = 19.3 % ID/g | Drug uptake in iv dosed Balb/C mouse brain after 2 min | ChEMBL. | 17319654 |
Drug uptake (ADMET) | = 19.3 % ID/g | Drug uptake in iv dosed Balb/C mouse brain after 2 min | ChEMBL. | 17319654 |
Ki (binding) | = 3.4 nM | Displacement of [3H]PIB from human Abeta40 peptide | ChEMBL. | 17319654 |
LogP | = 2.81 | Lipophilicity, log P of the compound | ChEMBL. | 17319654 |
Ratio (ADMET) | = 9.8 | Ratio of drug uptake in iv dosed Balb/C mouse brain at 2 to 30 mins | ChEMBL. | 17319654 |
t1/2 (ADMET) | = 22.1 min | Metabolic stability in Balb/C mouse plasma assessed as radioactivity | ChEMBL. | 17319654 |
T1/2 (ADMET) | = 22.1 min | Metabolic stability in Balb/C mouse plasma assessed as radioactivity | ChEMBL. | 17319654 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.