Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cyclin B, putative | 0.018 | 0.1895 | 0.1895 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0191 | 0.2166 | 0.0334 |
Trichomonas vaginalis | cyclin B, putative | 0.018 | 0.1895 | 0.1895 |
Trichomonas vaginalis | cyclin B, putative | 0.018 | 0.1895 | 0.1895 |
Giardia lamblia | Kinase, CMGC GSK | 0.0528 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0191 | 0.2166 | 0.0334 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0191 | 0.2166 | 0.2166 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0191 | 0.2166 | 0.0334 |
Giardia lamblia | Kinase, CMGC CDK | 0.0191 | 0.2166 | 0.2166 |
Trichomonas vaginalis | cyclin B, putative | 0.018 | 0.1895 | 0.1895 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0191 | 0.2166 | 0.0334 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0191 | 0.2166 | 0.2166 |
Trypanosoma brucei | protein kinase, putative | 0.0528 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0528 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0191 | 0.2166 | 0.2166 |
Trichomonas vaginalis | cyclins, putative | 0.018 | 0.1895 | 0.1895 |
Echinococcus granulosus | protein kinase shaggy | 0.0528 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.018 | 0.1895 | 0.1895 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0191 | 0.2166 | 0.2166 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0528 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0191 | 0.2166 | 0.2166 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0191 | 0.2166 | 0.2166 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0191 | 0.2166 | 0.0334 |
Plasmodium falciparum | protein kinase 5 | 0.0191 | 0.2166 | 0.2166 |
Trichomonas vaginalis | cyclin A, putative | 0.018 | 0.1895 | 0.1895 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.018 | 0.1895 | 0.1895 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0191 | 0.2166 | 0.0334 |
Echinococcus granulosus | cyclin dependent kinase | 0.0191 | 0.2166 | 0.2166 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0191 | 0.2166 | 0.2166 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0528 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0191 | 0.2166 | 0.0334 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0191 | 0.2166 | 0.2166 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0191 | 0.2166 | 0.0334 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0348 | 0.5803 | 0.4822 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0528 | 1 | 1 |
Entamoeba histolytica | cyclin, putative | 0.018 | 0.1895 | 0.1895 |
Echinococcus multilocularis | protein kinase shaggy | 0.0528 | 1 | 1 |
Schistosoma mansoni | cyclin B3 | 0.0348 | 0.5803 | 0.5803 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0528 | 1 | 1 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0528 | 1 | 1 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0528 | 1 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0528 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0528 | 1 | 1 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0528 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.2002 | 0.0132 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0191 | 0.2166 | 0.0334 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0348 | 0.5803 | 0.4822 |
Brugia malayi | cell division control protein 2 homolog | 0.0191 | 0.2166 | 0.0334 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0191 | 0.2166 | 0.2166 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0348 | 0.5803 | 0.5803 |
Echinococcus granulosus | cyclin B | 0.018 | 0.1895 | 0.1895 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0528 | 1 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0528 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0528 | 1 | 1 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0348 | 0.5803 | 0.5803 |
Giardia lamblia | Kinase, CMGC GSK | 0.0528 | 1 | 1 |
Echinococcus multilocularis | cyclin B | 0.018 | 0.1895 | 0.1895 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0191 | 0.2166 | 0.2166 |
Giardia lamblia | Kinase, CMGC CDK | 0.0191 | 0.2166 | 0.2166 |
Onchocerca volvulus | 0.0528 | 1 | 1 | |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0191 | 0.2166 | 0.0334 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0191 | 0.2166 | 0.2166 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0191 | 0.2166 | 0.0334 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0191 | 0.2166 | 0.2166 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0528 | 1 | 1 |
Schistosoma mansoni | cyclin B | 0.018 | 0.1895 | 0.1895 |
Trichomonas vaginalis | cyclins, putative | 0.018 | 0.1895 | 0.1895 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0191 | 0.2166 | 0.2166 |
Trichomonas vaginalis | cyclins, putative | 0.018 | 0.1895 | 0.1895 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0191 | 0.2166 | 0.0334 |
Entamoeba histolytica | protein kinase, putative | 0.0528 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0191 | 0.2166 | 0.2166 |
Trichomonas vaginalis | cyclins, putative | 0.0105 | 0.0165 | 0.0165 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 58 % | Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase at 10 uM | ChEMBL. | 17326615 |
Inhibition (binding) | = 58 % | Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase at 10 uM | ChEMBL. | 17326615 |
Inhibition (binding) | = 86 % | Inhibition of pig kidney microsomal APN at 10 uM | ChEMBL. | 17326615 |
Inhibition (binding) | = 86 % | Inhibition of pig kidney microsomal APN at 10 uM | ChEMBL. | 17326615 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.