Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, CMGC CDK | 0.0144 | 0.2782 | 0.4858 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0144 | 0.2782 | 0.2646 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0144 | 0.2782 | 0.0533 |
Entamoeba histolytica | protein kinase, putative | 0.0214 | 0.553 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0079 | 0.0185 | 0.0335 |
Echinococcus granulosus | cyclin dependent kinase | 0.0144 | 0.2782 | 0.2646 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0144 | 0.2782 | 0.2646 |
Entamoeba histolytica | cyclin, putative | 0.0134 | 0.2376 | 0.4098 |
Giardia lamblia | Kinase, CMGC GSK | 0.0214 | 0.553 | 1 |
Brugia malayi | cell division control protein 2 homolog | 0.0144 | 0.2782 | 0.0533 |
Echinococcus multilocularis | cyclin B | 0.0134 | 0.2376 | 0.2232 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0144 | 0.2782 | 0.1288 |
Trichomonas vaginalis | cyclins, putative | 0.0134 | 0.2376 | 0.4296 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0214 | 0.553 | 0.5446 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0144 | 0.2782 | 0.1288 |
Trichomonas vaginalis | cyclin B3, putative | 0.0079 | 0.0185 | 0.0335 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0144 | 0.2782 | 0.1288 |
Echinococcus multilocularis | protein kinase shaggy | 0.0214 | 0.553 | 0.5446 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0326 | 1 | 1 |
Schistosoma mansoni | cyclin B3 | 0.0326 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0214 | 0.553 | 1 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0214 | 0.553 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0214 | 0.553 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0144 | 0.2782 | 0.1288 |
Brugia malayi | intracellular kinase | 0.0214 | 0.553 | 0.4137 |
Plasmodium falciparum | protein kinase 5 | 0.0144 | 0.2782 | 0.4858 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.2641 | 0.0348 |
Trichomonas vaginalis | cyclins, putative | 0.0134 | 0.2376 | 0.4296 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0214 | 0.553 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0144 | 0.2782 | 0.0533 |
Giardia lamblia | Kinase, CMGC GSK | 0.0214 | 0.553 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0214 | 0.553 | 0.4137 |
Onchocerca volvulus | 0.0214 | 0.553 | 1 | |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0326 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0134 | 0.2376 | 0.4296 |
Trichomonas vaginalis | cyclin B, putative | 0.0079 | 0.0185 | 0.0335 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0326 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0134 | 0.2376 | 0.4296 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0144 | 0.2782 | 0.2646 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0214 | 0.553 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.0134 | 0.2376 | 0.4296 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0144 | 0.2782 | 0.4858 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0144 | 0.2782 | 0.0533 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0144 | 0.2782 | 0.2646 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0144 | 0.2782 | 0.5031 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0214 | 0.553 | 1 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0134 | 0.2376 | 0.4098 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0144 | 0.2782 | 0.5031 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0144 | 0.2782 | 0.1288 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0144 | 0.2782 | 0.2646 |
Trichomonas vaginalis | cyclin B, putative | 0.0134 | 0.2376 | 0.4296 |
Brugia malayi | Protein kinase domain containing protein | 0.0144 | 0.2782 | 0.0533 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0144 | 0.2782 | 0.4858 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0214 | 0.553 | 0.5446 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0144 | 0.2782 | 0.2646 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0214 | 0.553 | 0.5446 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0214 | 0.553 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0214 | 0.553 | 0.4137 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0214 | 0.553 | 1 |
Schistosoma mansoni | cyclin B | 0.0134 | 0.2376 | 0.2232 |
Trichomonas vaginalis | cyclins, putative | 0.0134 | 0.2376 | 0.4296 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0144 | 0.2782 | 0.1288 |
Trichomonas vaginalis | cyclin B, putative | 0.0134 | 0.2376 | 0.4296 |
Trichomonas vaginalis | cyclins, putative | 0.0134 | 0.2376 | 0.4296 |
Trichomonas vaginalis | cyclin D, putative | 0.0079 | 0.0185 | 0.0335 |
Trichomonas vaginalis | cyclins, putative | 0.0079 | 0.0185 | 0.0335 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0144 | 0.2782 | 0.1288 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0144 | 0.2782 | 0.2646 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0144 | 0.2782 | 0.2646 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0214 | 0.553 | 1 |
Echinococcus granulosus | cyclin B | 0.0134 | 0.2376 | 0.2232 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0144 | 0.2782 | 0.5031 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0144 | 0.2782 | 0.2646 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0144 | 0.2782 | 0.1288 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0214 | 0.553 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0144 | 0.2782 | 0.4858 |
Trichomonas vaginalis | cyclin D, putative | 0.0079 | 0.0185 | 0.0335 |
Echinococcus granulosus | protein kinase shaggy | 0.0214 | 0.553 | 0.5446 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 66 % | Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase at 10 uM | ChEMBL. | 17326615 |
Inhibition (binding) | = 66 % | Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase at 10 uM | ChEMBL. | 17326615 |
Inhibition (binding) | = 81 % | Inhibition of pig kidney microsomal APN at 10 uM | ChEMBL. | 17326615 |
Inhibition (binding) | = 81 % | Inhibition of pig kidney microsomal APN at 10 uM | ChEMBL. | 17326615 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.