Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | conserved hypothetical protein | Get druggable targets OG5_144688 | All targets in OG5_144688 |
Brugia malayi | Serotonin receptor | Get druggable targets OG5_135430 | All targets in OG5_135430 |
Echinococcus granulosus | hypothetical protein | Get druggable targets OG5_144688 | All targets in OG5_144688 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | protein kinase, putative | 0.026 | 0.2424 | 1 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0135 | 0.0783 | 0.2564 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.026 | 0.2424 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.0091 | 0.0217 | 0.066 |
Trichomonas vaginalis | cyclins, putative | 0.0135 | 0.0783 | 0.3231 |
Brugia malayi | intracellular kinase | 0.026 | 0.2424 | 0.358 |
Trichomonas vaginalis | cyclin B, putative | 0.0135 | 0.0783 | 0.3231 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.026 | 0.2424 | 0.2404 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0091 | 0.0217 | 0.0482 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0135 | 0.0783 | 0.2564 |
Giardia lamblia | Kinase, CMGC CDK | 0.0091 | 0.0217 | 0.066 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0783 | 0.1955 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0091 | 0.0217 | 0.0896 |
Schistosoma mansoni | cyclin B | 0.0135 | 0.0783 | 0.2232 |
Trichomonas vaginalis | cyclin D, putative | 0.0079 | 0.0061 | 0.0252 |
Trypanosoma cruzi | cyclin 6, putative | 0.0135 | 0.0783 | 0.2564 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0327 | 0.3296 | 0.3254 |
Entamoeba histolytica | protein kinase domain containing protein | 0.026 | 0.2424 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0135 | 0.0783 | 0.3231 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0091 | 0.0217 | 0.066 |
Trichomonas vaginalis | cyclin A, putative | 0.0135 | 0.0783 | 0.3231 |
Trichomonas vaginalis | cyclin B, putative | 0.0135 | 0.0783 | 0.3231 |
Trichomonas vaginalis | cyclin B, putative | 0.0135 | 0.0783 | 0.3231 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0327 | 0.3296 | 0.3292 |
Schistosoma mansoni | cyclin B3 | 0.0327 | 0.3296 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0091 | 0.0217 | 0.0159 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0091 | 0.0217 | 0.0482 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0091 | 0.0217 | 0.0159 |
Trichomonas vaginalis | cyclin D, putative | 0.0079 | 0.0061 | 0.0252 |
Onchocerca volvulus | 0.026 | 0.2424 | 1 | |
Trypanosoma cruzi | cyclin, putative | 0.0135 | 0.0783 | 0.2564 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0091 | 0.0217 | 0.0157 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0091 | 0.0217 | 0.066 |
Giardia lamblia | Kinase, CMGC CDK | 0.0091 | 0.0217 | 0.066 |
Entamoeba histolytica | protein kinase, putative | 0.026 | 0.2424 | 1 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0135 | 0.0783 | 0.2564 |
Entamoeba histolytica | protein kinase domain containing protein | 0.026 | 0.2424 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0091 | 0.0217 | 0.0143 |
Trichomonas vaginalis | cyclin B, putative | 0.0079 | 0.0061 | 0.0252 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.026 | 0.2424 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0091 | 0.0217 | 0.0143 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.026 | 0.2424 | 0.2377 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0833 | 0.9888 | 1 |
Echinococcus multilocularis | protein kinase shaggy | 0.026 | 0.2424 | 0.2404 |
Trichomonas vaginalis | cyclins, putative | 0.0135 | 0.0783 | 0.3231 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0091 | 0.0217 | 0.0896 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0135 | 0.0783 | 0.3056 |
Echinococcus multilocularis | cyclin B | 0.0135 | 0.0783 | 0.0735 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0091 | 0.0217 | 0.0143 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0091 | 0.0217 | 0.0157 |
Giardia lamblia | Kinase, CMGC GSK | 0.026 | 0.2424 | 1 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.026 | 0.2424 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.026 | 0.2424 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0079 | 0.0061 | 0.0252 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0091 | 0.0217 | 0.0157 |
Echinococcus granulosus | cyclin dependent kinase | 0.0091 | 0.0217 | 0.0157 |
Trichomonas vaginalis | CMGC family protein kinase | 0.026 | 0.2424 | 1 |
Echinococcus granulosus | cyclin B | 0.0135 | 0.0783 | 0.0726 |
Trichomonas vaginalis | cyclin B3, putative | 0.0079 | 0.0061 | 0.0252 |
Echinococcus granulosus | protein kinase shaggy | 0.026 | 0.2424 | 0.2377 |
Brugia malayi | Serotonin receptor | 0.0564 | 0.638 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.026 | 0.2424 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0091 | 0.0217 | 0.0159 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.026 | 0.2424 | 0.7208 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0783 | 0.1955 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.026 | 0.2424 | 0.7208 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0327 | 0.3296 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0091 | 0.0217 | 0.0159 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.026 | 0.2424 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0135 | 0.0783 | 0.3231 |
Trypanosoma cruzi | cyclin, putative | 0.0135 | 0.0783 | 0.2564 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0091 | 0.0217 | 0.0896 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0135 | 0.0783 | 0.0918 |
Trichomonas vaginalis | cyclins, putative | 0.0135 | 0.0783 | 0.3231 |
Trichomonas vaginalis | CMGC family protein kinase | 0.026 | 0.2424 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0135 | 0.0783 | 0.0918 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0079 | 0.0061 | 0.0252 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.026 | 0.2424 | 0.7304 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0327 | 0.3296 | 0.4995 |
Entamoeba histolytica | cyclin, putative | 0.0135 | 0.0783 | 0.3056 |
Leishmania major | cyclin | 0.0135 | 0.0783 | 0.2564 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 126 nM | Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay | ChEMBL. | 17315987 |
EC50 (functional) | = 293 nM | Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay | ChEMBL. | 17315987 |
EC50 (functional) | = 480 nM | Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay | ChEMBL. | 17315987 |
Intrinsic activity (functional) | = 1 | Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay relative to serotonin | ChEMBL. | 17315987 |
Intrinsic activity (functional) | = 1 | Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay relative to serotonin | ChEMBL. | 17315987 |
Intrinsic activity (functional) | = 1 | Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay relative to serotonin | ChEMBL. | 17315987 |
Intrinsic activity (functional) | = 1 | Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay relative to serotonin | ChEMBL. | 17315987 |
Intrinsic activity (functional) | = 1 | Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay relative to serotonin | ChEMBL. | 17315987 |
Intrinsic activity (functional) | = 1 | Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay relative to serotonin | ChEMBL. | 17315987 |
Ki (binding) | = 91 nM | Displacement of [125I]DOI from human recombinant 5HT2A expressed in HEK293E cells | ChEMBL. | 17315987 |
Ki (binding) | = 235 nM | Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells | ChEMBL. | 17315987 |
Ki (binding) | = 335 nM | Displacement of [125I]DOI from human recombinant 5HT2C expressed in HEK293E cells | ChEMBL. | 17315987 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.