Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | p-glycoprotein | 0.0015 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0448 | 0.0433 |
Brugia malayi | multidrug resistance related protein 1 | 0.0015 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0433 | 0.0418 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0015 | 0.0448 | 0.5 |
Leishmania major | ABC-thiol transporter | 0.0015 | 0.0448 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0015 | 0.0448 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0015 | 0.0448 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0015 | 0.0448 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0448 | 0.0433 |
Leishmania major | pentamidine resistance protein 1 | 0.0015 | 0.0448 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0015 | 0.0448 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0015 | 0.0448 | 0.5 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0015 | 0.0448 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0015 | 0.0448 | 1 |
Giardia lamblia | ABC transporter, putative | 0.0015 | 0.0448 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 1 | 1 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0015 | 0.0448 | 0.5 |
Entamoeba histolytica | ABC transporter, putative | 0.0015 | 0.0448 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0089 | 1 | 1 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0015 | 0.0448 | 0.5 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0015 | 0.0448 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0015 | 0.0448 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0015 | 0.0448 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0015 | 0.0448 | 1 |
Giardia lamblia | MRP-like ABC transporter | 0.0015 | 0.0448 | 1 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0015 | 0.0448 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0015 | 0.0448 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.0015 | 0.0448 | 0.5 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0015 | 0.0448 | 0.0433 |
Schistosoma mansoni | multidrug resistance protein | 0.0015 | 0.0448 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0015 | 0.0448 | 1 |
Leishmania major | p-glycoprotein e | 0.0015 | 0.0448 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0015 | 0.0448 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0015 | 0.0448 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0089 | 1 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0015 | 0.0448 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0015 | 0.0448 | 1 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0015 | 0.0448 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0015 | 0.0448 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.0015 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 1 | 1 |
Trypanosoma brucei | multidrug resistance protein E | 0.0015 | 0.0448 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 28 uM | Inhibition of human cPLA2 alpha by GLU micelle assay | ChEMBL. | 17305324 |
IC50 (binding) | = 28 uM | Inhibition of human cPLA2 alpha by GLU micelle assay | ChEMBL. | 17305324 |
Inhibition (functional) | = 13 % | Inhibition of A23187-stimulated TXB2 production in Sprague-Dawley rat whole blood at 10 uM | ChEMBL. | 17305324 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.