Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APH1B gamma secretase subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma japonicum | ko:K06172 anterior pharynx defective 1, putative | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus granulosus | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Brugia malayi | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0171 | 0.0165 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0113 | 0.0171 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0113 | 0.0171 | 0.1257 |
Loa Loa (eye worm) | hypothetical protein | 0.1624 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0113 | 0.0171 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0113 | 0.0171 | 0.1257 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0113 | 0.0171 | 0.5 |
Entamoeba histolytica | ABC transporter, putative | 0.0113 | 0.0171 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0113 | 0.0171 | 0.1257 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0113 | 0.0171 | 0.9256 |
Loa Loa (eye worm) | hypothetical protein | 0.1624 | 1 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0113 | 0.0171 | 0.5 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0296 | 0.1359 | 0.1209 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0171 | 0.0165 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0113 | 0.0171 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0113 | 0.0171 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0165 | 0.0159 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0113 | 0.0171 | 0.5 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0113 | 0.0171 | 0.9256 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0673 | 0.3811 | 0.3807 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0.0185 | 1 |
Leishmania major | ABC-thiol transporter | 0.0113 | 0.0171 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0113 | 0.0171 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0673 | 0.3811 | 0.3807 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0115 | 0.0185 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0296 | 0.1359 | 0.1354 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.1624 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0673 | 0.3811 | 0.3807 |
Loa Loa (eye worm) | hypothetical protein | 0.1425 | 0.87 | 0.8699 |
Toxoplasma gondii | hypothetical protein | 0.0673 | 0.3811 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0113 | 0.0171 | 0.9256 |
Leishmania major | pentamidine resistance protein 1 | 0.0113 | 0.0171 | 0.5 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0296 | 0.1359 | 1 |
Giardia lamblia | ABC transporter, putative | 0.0113 | 0.0171 | 1 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0296 | 0.1359 | 0.1209 |
Leishmania major | p-glycoprotein e | 0.0113 | 0.0171 | 0.5 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0.0185 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0673 | 0.3811 | 0.3807 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0113 | 0.0171 | 0.0165 |
Giardia lamblia | MRP-like ABC transporter | 0.0113 | 0.0171 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.0171 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0113 | 0.0171 | 0.5 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0296 | 0.1359 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0113 | 0.0171 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0113 | 0.0171 | 1 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0113 | 0.0171 | 0.1257 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 uM | Inhibition of gamma secretase isolated from HeLa cells by ELISA | ChEMBL. | 15588083 |
IC50 (binding) | = 2 uM | Inhibition of gamma secretase isolated from HeLa cells by ELISA | ChEMBL. | 15588083 |
IC50 (binding) | = 8 uM | Inhibition of gamma secretase in CHO cells expressing human APP by ELISA | ChEMBL. | 15588083 |
IC50 (binding) | = 8 uM | Inhibition of gamma secretase in CHO cells expressing human APP by ELISA | ChEMBL. | 15588083 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.