TDR Targets

Basic information

Technical information

TDR Targets ID: 418085
Name: 2-morpholin-4-yl-6-(4-naphthalen-2-ylphenyl)t hiopyran-4-one
MW: 399.505 | Formula: C25H21NO2S
H donors: 0 H acceptors: 1 LogP: 5.14 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=c1cc(sc(c1)c1ccc(cc1)c1ccc2c(c1)cccc2)N1CCOCC1
InChi: 1S/C25H21NO2S/c27-23-16-24(29-25(17-23)26-11-13-28-14-12-26)20-8-5-19(6-9-20)22-10-7-18-3-1-2-4-21(18)15-22/h1-10,15-17H,11-14H2
InChiKey: BHOWMOFRQZHYRQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-morpholino-6-[4-(2-naphthyl)phenyl]thiopyran-4-one
2-morpholino-6-[4-(2-naphthalenyl)phenyl]-4-thiopyranone
2-morpholino-6-[4-(2-naphthyl)phenyl]-4-thiopyranone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0118	0.35	1
Brugia malayi	serine/threonine-protein kinase 6	0.0172	0.5289	0.7329
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.1142	0.1582
Leishmania major	hypothetical protein, conserved	0.0114	0.3368	0.6367
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.1545	0.1273
Trichomonas vaginalis	AGC family protein kinase	0.0172	0.5289	1
Echinococcus granulosus	NADH dehydrogenase subunit 4	0.0305	0.9712	0.9703
Trypanosoma brucei	aurora B kinase	0.0172	0.5289	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0172	0.5289	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M)	0.0254	0.802	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.183	0.2536
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.0311	0.0588
Schistosoma mansoni	NADH dehydrogenase subunit 5	0.0051	0.1278	0.1942
Onchocerca volvulus		0.0118	0.35	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Onchocerca volvulus		0.0118	0.35	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.183	0.2536
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0311	0.0431
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0068	0.183	0.2536
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0068	0.183	0.2536
Onchocerca volvulus		0.005	0.1256	0.0484
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0311	0.0431
Brugia malayi	NADH dehydrogenase subunit 4	0.0051	0.1278	0.1771
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0022	0.0311	0.0588
Giardia lamblia	Aurora kinase	0.0172	0.5289	1
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0172	0.5289	0.5
Toxoplasma gondii	aurora kinase	0.0172	0.5289	1
Onchocerca volvulus		0.0068	0.183	0.2917
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0022	0.0311	0.0588
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Mycobacterium ulcerans	oxidoreductase	0.0051	0.1278	0.1315
Entamoeba histolytica	protein kinase , putative	0.0172	0.5289	1
Loa Loa (eye worm)	AUR protein kinase	0.0172	0.5289	0.7329
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Loa Loa (eye worm)	hypothetical protein	0.005	0.1256	0.1741
Mycobacterium ulcerans	NADH dehydrogenase subunit L	0.0051	0.1278	0.1315
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.1545	0.2921
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0311	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0068	0.183	0.2536
Loa Loa (eye worm)	hypothetical protein	0.023	0.7216	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0041	0.0057
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1545	0.2479
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0172	0.5289	1
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0172	0.5289	0.5138
Echinococcus multilocularis	aurora kinase A	0.0172	0.5289	0.5138
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0022	0.0311	0.0588
Wolbachia endosymbiont of Brugia malayi	NADH:ubiquinone oxidoreductase chain M	0.0305	0.9712	1
Trichomonas vaginalis	AGC family protein kinase	0.0172	0.5289	1
Loa Loa (eye worm)	AUR protein kinase	0.0172	0.5289	0.7329
Trypanosoma cruzi	target of rapamycin kinase 3	0.0022	0.0311	0.0588
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0118	0.35	0.4851
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Onchocerca volvulus		0.0068	0.183	0.2917
Onchocerca volvulus		0.0118	0.35	1
Schistosoma mansoni	NADH dehydrogenase subunit 4	0.0051	0.1278	0.1942
Onchocerca volvulus		0.0118	0.35	1
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0118	0.35	0.4851
Schistosoma mansoni	protein kinase	0.0172	0.5289	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.0311	0.0588
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.0311	0.0588
Brugia malayi	LBP/BPI	0.005	0.1256	0.1741
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0172	0.5289	0.5138
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0118	0.35	0.4851
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Brugia malayi	hypothetical protein	0.005	0.1256	0.1741
Brugia malayi	hypothetical protein	0.0068	0.183	0.2536
Entamoeba histolytica	protein kinase domain containing protein	0.0172	0.5289	1
Echinococcus granulosus	survival motor neuron protein 1	0.023	0.7216	0.7127
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.1256	0.2315
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.3228	0.6103
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0022	0.0311	0.0588
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0313	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Loa Loa (eye worm)	AUR protein kinase	0.0172	0.5289	0.7329
Leishmania major	protein kinase, putative	0.0172	0.5289	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0118	0.35	0.4851
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0068	0.183	0.2536
Brugia malayi	hypothetical protein	0.0051	0.1278	0.1771
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0118	0.35	0.4851
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.0311	0.0588
Echinococcus granulosus	aurora kinase A	0.0172	0.5289	0.5138
Mycobacterium ulcerans	NADH dehydrogenase subunit M	0.0305	0.9712	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1545	0.2479
Trichomonas vaginalis	AGC family protein kinase	0.0172	0.5289	1
Trypanosoma cruzi	aurora B kinase, putative	0.0172	0.5289	1
Mycobacterium ulcerans	NADH dehydrogenase subunit N	0.0051	0.1278	0.1315
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Brugia malayi	serine/threonine kinase 12	0.0172	0.5289	0.7329
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Loa Loa (eye worm)	hypothetical protein	0.005	0.1256	0.1741
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0.0311	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0051	0.1278	0.1771
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.0311	0.0588
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0014	0.0041	0.0078
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.1545	0.1273
Brugia malayi	hypothetical protein	0.023	0.7216	1
Loa Loa (eye worm)	NADH dehydrogenase subunit 5	0.0051	0.1278	0.1771
Trichomonas vaginalis	AGC family protein kinase	0.0172	0.5289	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Loa Loa (eye worm)	NADH dehydrogenase subunit 4	0.0051	0.1278	0.1771
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0022	0.0311	0.0588
Mycobacterium ulcerans	hydrogenase HycQ	0.0051	0.1278	0.1315
Entamoeba histolytica	protein kinase, putative	0.0172	0.5289	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0068	0.183	0.2536
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0311	0.0431
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Entamoeba histolytica	protein kinase, putative	0.0172	0.5289	1
Schistosoma mansoni	hypothetical protein	0.0047	0.1142	0.1669
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0172	0.5289	1
Onchocerca volvulus		0.0051	0.1278	0.0575
Onchocerca volvulus		0.0118	0.35	1
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0022	0.0311	0.0588
Loa Loa (eye worm)	hypothetical protein	0.0068	0.183	0.2536
Loa Loa (eye worm)	hypothetical protein	0.005	0.1256	0.1741
Echinococcus multilocularis	survival motor neuron protein 1	0.023	0.7216	0.7127
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1545	0.1591
Onchocerca volvulus		0.0118	0.35	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0172	0.5289	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Onchocerca volvulus		0.0118	0.35	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1545	0.1591
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Brugia malayi	serine/threonine protein kinase 6	0.0172	0.5289	0.7329
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0311	0.0588
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0311	0.0514
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0022	0.0311	0.0588
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0068	0.183	0.2536
Brugia malayi	hypothetical protein	0.0068	0.183	0.2536
Loa Loa (eye worm)	hypothetical protein	0.005	0.1256	0.1741
Brugia malayi	NADH dehydrogenase subunit 5	0.0051	0.1278	0.1771
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.1545	0.2865
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.1545	0.0396
Schistosoma mansoni	serine/threonine protein kinase	0.0172	0.5289	1
Loa Loa (eye worm)	NADH dehydrogenase subunit 5	0.0051	0.1278	0.1771
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0311	0.0588
Schistosoma mansoni	survival motor neuron protein	0.0047	0.1142	0.1669
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0068	0.183	0.2536
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1545	0.1591

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 0 %	Inhibition of DNA-PK in HeLa cell nuclear extracts at 1.0 uM	ChEMBL.	17371003
Inhibition (binding)	= 0 %	Inhibition of DNA-PK in HeLa cell nuclear extracts at 1.0 uM	ChEMBL.	17371003

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 16203251

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 418085