Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 0.1362 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0093 | 0.2157 | 0.2157 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 0.1362 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.014 | 0.4346 | 0.3454 |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 0.1362 | 0.5 |
Leishmania major | trypanothione reductase | 0.0076 | 0.1362 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 0.1362 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0076 | 0.1362 | 0.5 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0261 | 1 | 1 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0261 | 1 | 1 |
Brugia malayi | Hemopexin family protein | 0.0055 | 0.0359 | 0.0359 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.014 | 0.4346 | 0.3454 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 1 | 1 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0261 | 1 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0139 | 0.4285 | 0.4285 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.007 | 0.1096 | 0.1096 |
Loa Loa (eye worm) | glutathione reductase | 0.0076 | 0.1362 | 0.1362 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0139 | 0.4285 | 0.4072 |
Onchocerca volvulus | Matrilysin homolog | 0.0085 | 0.1797 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0085 | 0.1797 | 0.1797 |
Brugia malayi | Thioredoxin reductase | 0.0076 | 0.1362 | 0.1362 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0085 | 0.1797 | 1 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0139 | 0.4285 | 0.4072 |
Brugia malayi | glutathione reductase | 0.0076 | 0.1362 | 0.1362 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0076 | 0.1362 | 0.1362 |
Mycobacterium ulcerans | hydrolase | 0.0047 | 0 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0093 | 0.2157 | 0.2157 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0047 | 0 | 0.5 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0068 | 0.1 | 0.1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 0.1362 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 0.1362 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 0.1362 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.4285 | 0.4285 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.42 ug ml-1 | Antileishmanial activity against Leishmania donovani promastigotes | ChEMBL. | 17134906 |
IC50 (functional) | = 0.42 ug ml-1 | Antileishmanial activity against Leishmania donovani promastigotes | ChEMBL. | 17134906 |
IC50 (functional) | = 2 ug ml-1 | Antifungal activity against Candida albicans ATCC 90028 by CLSI method | ChEMBL. | 21134759 |
IC50 (functional) | = 2.8 ug ml-1 | Antiinfective activity against Plasmodium falciparum W2 in red blood cells | ChEMBL. | 17134906 |
IC50 (functional) | = 2.8 ug ml-1 | Antiinfective activity against Plasmodium falciparum W2 in red blood cells | ChEMBL. | 17134906 |
IC50 (functional) | = 4 ug ml-1 | Antiinfective activity against Plasmodium falciparum D6 infected red blood cells | ChEMBL. | 17134906 |
IC50 (functional) | = 15 ug ml-1 | Antifungal activity against Cryptococcus neoformans ATCC 90113 by CLSI method | ChEMBL. | 21134759 |
IC50 (functional) | > 20 ug ml-1 | Antibacterial activity against Mycobacterium intracellulare ATCC 23068 | ChEMBL. | 17134906 |
IC50 (ADMET) | > 23.8 ug ml-1 | Cytotoxicity against Vero cells | ChEMBL. | 17134906 |
MIC (functional) | = 2 ug ml-1 | Antifungal activity against Candida albicans ATCC 90028 | ChEMBL. | 17134906 |
MIC (functional) | = 2 ug ml-1 | Antifungal activity against Candida albicans ATCC 90028 | ChEMBL. | 17134906 |
MIC (functional) | = 4 ug ml-1 | Antibacterial activity against Aspergillus fumigatus ATCC 90906 | ChEMBL. | 17134906 |
MIC (functional) | = 15 ug ml-1 | Antifungal activity against Cryptococcus neoformans ATCC 90113 | ChEMBL. | 17134906 |
MIC (functional) | = 15 ug ml-1 | Antifungal activity against Cryptococcus neoformans ATCC 90113 | ChEMBL. | 17134906 |
MIC (functional) | > 20 ug ml-1 | Antifungal activity against Cryptococcus neoformans ATCC 90113 by CLSI method | ChEMBL. | 21134759 |
MIC (functional) | > 20 ug ml-1 | Antifungal activity against Candida albicans ATCC 90028 by CLSI method | ChEMBL. | 21134759 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 17134906 | |
Candida albicans | ChEMBL23 | 21134759 | |
Leishmania donovani | ChEMBL23 | 17134906 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.