Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog | Adenosine A1 receptor | 326 aa | 286 aa | 22.7 % |
Echinococcus multilocularis | allatostatin A receptor | Adenosine A1 receptor | 326 aa | 306 aa | 26.1 % |
Schistosoma mansoni | opsin-like receptor | Adenosine A1 receptor | 326 aa | 312 aa | 22.1 % |
Loa Loa (eye worm) | hypothetical protein | Adenosine A1 receptor | 326 aa | 296 aa | 22.6 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Adenosine A1 receptor | 326 aa | 312 aa | 24.0 % |
Schistosoma mansoni | neuropeptide receptor | Adenosine A1 receptor | 326 aa | 277 aa | 23.8 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Adenosine A1 receptor | 326 aa | 318 aa | 22.3 % |
Schistosoma japonicum | 5-hydroxytryptamine receptor 4, putative | Adenosine A1 receptor | 326 aa | 301 aa | 25.6 % |
Onchocerca volvulus | Adenosine A1 receptor | 326 aa | 307 aa | 21.2 % | |
Schistosoma mansoni | opsin-like receptor | Adenosine A1 receptor | 326 aa | 315 aa | 23.8 % |
Echinococcus granulosus | allatostatin A receptor | Adenosine A1 receptor | 326 aa | 304 aa | 25.3 % |
Brugia malayi | hypothetical protein | Adenosine A1 receptor | 326 aa | 311 aa | 21.9 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Adenosine A1 receptor | 326 aa | 331 aa | 25.7 % |
Loa Loa (eye worm) | neuropeptide F receptor | Adenosine A1 receptor | 326 aa | 316 aa | 19.3 % |
Onchocerca volvulus | Adenosine A1 receptor | 326 aa | 326 aa | 20.2 % | |
Schistosoma mansoni | neuropeptide receptor | Adenosine A1 receptor | 326 aa | 314 aa | 21.7 % |
Onchocerca volvulus | Adenosine A1 receptor | 326 aa | 311 aa | 21.9 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 50 % | Displacement of [3H]ZM241385 from human recombinant adenosine A2A receptor expressed in CHO cells at 1 uM | ChEMBL. | 17028066 |
Inhibition (binding) | < 50 % | Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed in CHO cells at 1 uM | ChEMBL. | 17028066 |
Inhibition (binding) | < 50 % | Displacement of [3H]ZM241385 from human recombinant adenosine A2A receptor expressed in CHO cells at 1 uM | ChEMBL. | 17028066 |
Inhibition (binding) | < 50 % | Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed in CHO cells at 1 uM | ChEMBL. | 17028066 |
Ki (binding) | = 1.8794 | Binding affinity to bovine adenosine A1 receptor | ChEMBL. | 17418915 |
Ki (binding) | = 13.2 nM | Displacement of [3H]DPCPX from bovine cerbral cortex adenosine A1 receptor | ChEMBL. | 17028066 |
Ki (binding) | = 13.2 nM | Displacement of [3H]DPCPX from bovine cerbral cortex adenosine A1 receptor | ChEMBL. | 17028066 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.