TDR Targets

Basic information

Technical information

TDR Targets ID: 422974
Name: 2-phenyl-1-[4-(7H-purin-6-yl)phenyl]ethanamin e
MW: 315.372 | Formula: C19H17N5
H donors: 2 H acceptors: 3 LogP: 2.61 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NC(c1ccc(cc1)c1ncnc2c1nc[nH]2)Cc1ccccc1
InChi: 1S/C19H17N5/c20-16(10-13-4-2-1-3-5-13)14-6-8-15(9-7-14)17-18-19(23-11-21-17)24-12-22-18/h1-9,11-12,16H,10,20H2,(H,21,22,23,24)
InChiKey: HJFKANRRGGLIMD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[2-phenyl-1-[4-(7H-purin-6-yl)phenyl]ethyl]amine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase, cAMP-dependent, catalytic, beta		References
Homo sapiens	v-akt murine thymoma viral oncogene homolog 2	Starlite/ChEMBL	References
Homo sapiens	protein kinase, cAMP-dependent, catalytic, gamma	Starlite/ChEMBL	References
Homo sapiens	protein kinase, cAMP-dependent, catalytic, alpha		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium berghei	cAMP-dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	Get druggable targets OG5_126748	All targets in OG5_126748
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	Get druggable targets OG5_126748	All targets in OG5_126748
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126748	All targets in OG5_126748
Neospora caninum	AGC kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Loa Loa (eye worm)	AGC/PKA protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Candida albicans	protein kinase A	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	cAMP-dependent protein kinase catalytic subunit alpha, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma brucei gambiense	protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma brucei	protein kinase A catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/PKA protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	cAMP-dependent protein kinase catalytic subunit alpha, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	rac serine:threonine kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta-1, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Leishmania major	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium berghei	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma congolense	cAMP-dependent protein kinase catalytic subunit 1	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania braziliensis	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Cryptosporidium hominis	protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania donovani	protein kinase A catalytic subunit 3	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium yoelii	kinase Akt/PKB-related	Get druggable targets OG5_126635	All targets in OG5_126635
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	Protein kinase DC2, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania mexicana	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma congolense	protein kinase A catalytic subunit 3	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma brucei gambiense	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K04456 RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma congolense	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	Get druggable targets OG5_126748	All targets in OG5_126748
Theileria parva	cAMP-dependent protein kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Cryptosporidium parvum	protein kinase, cAMP-dependent, catalytic chain	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	ko:K07390 monothiol glutaredoxin, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	Protein kinase B	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma brucei gambiense	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium knowlesi	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	enhancer of mRNA decapping protein 4	Get druggable targets OG5_126748	All targets in OG5_126748
Candida albicans	likely protein kinase similar to S. cerevisiae YPK2 (YMR104C)	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Leishmania infantum	protein kinase A catalytic subunit isoform 1	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma brucei gambiense	protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Neospora caninum	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Candida albicans	protein kinase A	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania mexicana	protein kinase A catalytic subunit isoform 2	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma congolense	cAMP-dependent protein kinase catalytic subunit 1	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K04345 protein kinase A, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/AKT protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium knowlesi	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	Get druggable targets OG5_126748	All targets in OG5_126748
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K08792 serum/glucocorticoid regulated kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase 2, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	p70 ribosomal S6 kinase beta	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Candida albicans	cAMP-dependent protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Leishmania braziliensis	protein kinase A catalytic subunit isoform 1	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Neospora caninum	AGC kinase, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Candida albicans	cAMP-dependent protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Theileria parva	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K04345 protein kinase A, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Schistosoma japonicum	RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Leishmania infantum	protein kinase A catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma brucei	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing	Get druggable targets OG5_126748	All targets in OG5_126748
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania infantum	protein kinase A catalytic subunit isoform 2	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania mexicana	protein kinase A catalytic subunit isoform 1	Get druggable targets OG5_126748	All targets in OG5_126748
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_126748	All targets in OG5_126748
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	Get druggable targets OG5_126748	All targets in OG5_126748
Candida albicans	protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	Get druggable targets OG5_126748	All targets in OG5_126748
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine threonine protein kinase nrc	Get druggable targets OG5_126635	All targets in OG5_126635
Leishmania major	protein kinase A catalytic subunit isoform 1	Get druggable targets OG5_126748	All targets in OG5_126748
Leishmania major	protein kinase A catalytic subunit isoform 2	Get druggable targets OG5_126748	All targets in OG5_126748
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126635	All targets in OG5_126635

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	protein lipid droplet kinase (LDK)	protein kinase, cAMP-dependent, catalytic, beta	358 aa	320 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0146	0.116	0.0874
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0035	0.0163	0.1269
Brugia malayi	latrophilin 2 splice variant baaae	0.0023	0.0055	0.0318
Toxoplasma gondii	AGC kinase	0.0146	0.116	0.0874
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0314	0.2707
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.0018	0.0158
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0567	0.4933	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0033	0.0145	0.1109
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0314	0.2707
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0146	0.116	1
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0146	0.116	1
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.0018	0.0158
Loa Loa (eye worm)	hypothetical protein	0.1132	1	1
Schistosoma mansoni	hypothetical protein	0.0023	0.0055	0.0318
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0146	0.116	1
Echinococcus multilocularis	Glutaredoxin protein 5	0.0033	0.0145	0.0258
Echinococcus granulosus	serine/threonine protein kinase	0.0035	0.0163	0.1269
Echinococcus granulosus	Glutaredoxin protein 5	0.0033	0.0145	0.1109
Echinococcus granulosus	serine threonine protein kinase nrc	0.0035	0.0163	0.1269
Loa Loa (eye worm)	hypothetical protein	0.1132	1	1
Toxoplasma gondii	hypothetical protein	0.1132	1	1
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0146	0.116	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0035	0.0163	0.1269
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0146	0.116	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0146	0.116	1
Giardia lamblia	Kinase, AGC PKA	0.0146	0.116	1
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0146	0.116	1
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0314	0.2707
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0052	0.0314	0.0296
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0146	0.116	1
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0146	0.116	1
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0146	0.116	0.1144
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0314	0.2707
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0314	0.2707
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0314	0.2707
Echinococcus multilocularis	nervana 2	0.0033	0.0145	0.0258
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0032	0.0136	0.103
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0146	0.116	1
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0314	0.2591
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0032	0.0136	0.0239
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0144	0.1142	0.2286
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0146	0.116	0.2323
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.0018	0.0158
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0033	0.0145	0.0258
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.0018	0.0158
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0032	0.0136	0.103
Loa Loa (eye worm)	hypothetical protein	0.0146	0.116	0.1144
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.116	1
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0146	0.116	1
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0146	0.116	0.1144
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0314	0.2707
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0034	0.015	0.0132
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0146	0.116	0.5
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0146	0.116	0.2323
Entamoeba histolytica	protein kinase, putative	0.0052	0.0314	0.2591
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0034	0.015	0.1151
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0032	0.0136	0.103
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0146	0.116	1
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0146	0.116	0.2323
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.116	1
Entamoeba histolytica	protein kinase, putative	0.0052	0.0314	0.2591
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0032	0.0136	0.103
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0052	0.0314	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0034	0.015	0.0132
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0144	0.1142	0.984
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.1132	1	1
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0146	0.116	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0035	0.0163	0.1269
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0032	0.0136	0.103
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0146	0.116	1
Brugia malayi	p70 ribosomal S6 kinase beta	0.0052	0.0314	0.2591
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0035	0.0163	0.0295
Entamoeba histolytica	protein kinase 2, putative	0.0035	0.0163	0.1269
Schistosoma mansoni	serine/threonine-protein kinase	0.0035	0.0163	0.1269
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0146	0.116	0.2323
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0034	0.015	0.1151
Leishmania major	protein kinase A catalytic subunit	0.0146	0.116	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0146	0.116	1
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0146	0.116	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0032	0.0136	0.0118
Echinococcus multilocularis	nervana 2	0.0033	0.0145	0.0258
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0035	0.0163	0.1269
Toxoplasma gondii	AGC kinase	0.0146	0.116	0.0874
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.116	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0055	0.0036
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0032	0.0136	0.103
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0032	0.0136	0.0239
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0146	0.116	1
Echinococcus granulosus	nervana 2	0.0033	0.0145	0.1109
Echinococcus multilocularis	rac serine:threonine kinase	0.0035	0.0163	0.0295
Entamoeba histolytica	protein kinase, putative	0.0052	0.0314	0.2591
Echinococcus granulosus	nervana 2	0.0033	0.0145	0.1109

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	= 32 uM	Inhibition of PC3M cells by SRB assay after 96 hrs	ChEMBL.	17451235
IC50 (binding)	= 0.43 uM	Inhibition of PKBbeta by radiometric filter binding assay	ChEMBL.	17451235
IC50 (binding)	= 0.43 uM	Inhibition of PKBbeta by radiometric filter binding assay	ChEMBL.	17451235
IC50 (binding)	= 0.61 uM	Inhibition of PKA by radiometric filter binding assay	ChEMBL.	17451235
IC50 (binding)	= 0.61 uM	Inhibition of PKA by radiometric filter binding assay	ChEMBL.	17451235

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL227605
PubChem: 11695362

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 422974