Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Histone deacetylase 1 | 0.0343 | 0.3726 | 0.8201 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0162 | 0.1658 | 0.3649 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0414 | 0.4544 | 0.4544 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0343 | 0.3726 | 0.8201 |
Trypanosoma brucei | histone deacetylase 3 | 0.0414 | 0.4544 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0414 | 0.4544 | 0.9699 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0414 | 0.4544 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0343 | 0.3726 | 0.8201 |
Brugia malayi | Histone deacetylase family protein | 0.0414 | 0.4544 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0343 | 0.3726 | 0.8201 |
Trypanosoma brucei | histone deacetylase 4 | 0.0414 | 0.4544 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0414 | 0.4544 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.0162 | 0.1658 | 0.3649 |
Leishmania major | histone deacetylase, putative | 0.0343 | 0.3726 | 0.8201 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0343 | 0.3726 | 0.8201 |
Loa Loa (eye worm) | hypothetical protein | 0.0343 | 0.3726 | 0.8201 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0162 | 0.1658 | 0.3649 |
Trypanosoma brucei | histone deacetylase 1 | 0.0343 | 0.3726 | 0.8201 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0414 | 0.4544 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0427 | 0.4685 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0414 | 0.4544 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0343 | 0.3726 | 0.8201 |
Echinococcus granulosus | histone deacetylase 7 | 0.0414 | 0.4544 | 0.9699 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0414 | 0.4544 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0343 | 0.3726 | 0.8201 |
Echinococcus granulosus | histone deacetylase 6 | 0.0414 | 0.4544 | 0.9699 |
Plasmodium vivax | histone deacetylase, putative | 0.0414 | 0.4544 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.2822 | 0.6211 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0343 | 0.3726 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0343 | 0.3726 | 0.3726 |
Brugia malayi | Histone deacetylase family protein | 0.0414 | 0.4544 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0343 | 0.3726 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0427 | 0.4685 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0343 | 0.3726 | 0.8201 |
Plasmodium falciparum | histone deacetylase 2 | 0.0414 | 0.4544 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0343 | 0.3726 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.1658 | 0.3649 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0162 | 0.1658 | 0.1658 |
Schistosoma mansoni | histone deacetylase | 0.0343 | 0.3726 | 0.7954 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0343 | 0.3726 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0414 | 0.4544 | 1 |
Brugia malayi | histone deacetylase 11 | 0.0162 | 0.1658 | 0.3649 |
Plasmodium falciparum | histone deacetylase 1 | 0.0343 | 0.3726 | 0.5352 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0343 | 0.3726 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0162 | 0.1658 | 0.3539 |
Echinococcus granulosus | histone deacetylase | 0.0414 | 0.4544 | 0.9699 |
Echinococcus multilocularis | histone deacetylase | 0.0414 | 0.4544 | 0.4544 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0162 | 0.1658 | 0.3539 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0343 | 0.3726 | 0.3726 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0162 | 0.1658 | 0.3649 |
Giardia lamblia | Histone deacetylase | 0.0343 | 0.3726 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0343 | 0.3726 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0414 | 0.4544 | 0.9699 |
Trypanosoma brucei | histone deacetylase, putative | 0.0414 | 0.4544 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0343 | 0.3726 | 0.7954 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0261 | 0.2785 | 0.6129 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0343 | 0.3726 | 0.7167 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0343 | 0.3726 | 1 |
Plasmodium falciparum | histone deacetylase, putative | 0.0414 | 0.4544 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase, putative | 0.0244 | 0.2588 | 0.3223 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0414 | 0.4544 | 0.4544 |
Trypanosoma brucei | histone deacetylase 2 | 0.0162 | 0.1658 | 0.3649 |
Echinococcus granulosus | histone deacetylase 1 | 0.0343 | 0.3726 | 0.7954 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0414 | 0.4544 | 0.9699 |
Echinococcus granulosus | histone deacetylase 3 | 0.0343 | 0.3726 | 0.7954 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0414 | 0.4544 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.2681 | 0.5901 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0343 | 0.3726 | 1 |
Leishmania major | histone deacetylase, putative | 0.0343 | 0.3726 | 0.8201 |
Echinococcus granulosus | histone deacetylase 8 | 0.0162 | 0.1658 | 0.3539 |
Leishmania major | histone deacetylase, putative | 0.0414 | 0.4544 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0343 | 0.3726 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0162 | 0.1658 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0414 | 0.4544 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0414 | 0.4544 | 0.4544 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0343 | 0.3726 | 0.7167 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0343 | 0.3726 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0427 | 0.4685 | 0.4685 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 54.8 uM | Inhibition of human recombinant PRMT1 by TRF assay | ChEMBL. | 17432842 |
IC50 (binding) | = 54.8 uM | Inhibition of human recombinant PRMT1 by TRF assay | ChEMBL. | 17432842 |
Inhibition (binding) | = 34.9 % | Inhibition of Aspergillus nidulans RmtA at 2 uM by TRF assay | ChEMBL. | 17432842 |
Inhibition (binding) | = 34.9 % | Inhibition of Aspergillus nidulans RmtA at 2 uM by TRF assay | ChEMBL. | 17432842 |
Inhibition (binding) | = 64.68 % | Inhibition of Aspergillus nidulans RmtA at 10 uM by TRF assay | ChEMBL. | 17432842 |
Inhibition (binding) | = 64.68 % | Inhibition of Aspergillus nidulans RmtA at 10 uM by TRF assay | ChEMBL. | 17432842 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.