Detailed information for compound 427099

Basic information

Technical information
  • TDR Targets ID: 427099
  • Name: (2S)-1-[5-(1H-pyrazolo[3,4-c]pyridin-5-yl)pyr idin-3-yl]oxy-3-[3-(trifluoromethyl)phenyl]pr opan-2-amine
  • MW: 413.396 | Formula: C21H18F3N5O
  • H donors: 2 H acceptors: 3 LogP: 3.01 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@@H](Cc1cccc(c1)C(F)(F)F)COc1cncc(c1)c1ncc2c(c1)cn[nH]2
  • InChi: 1S/C21H18F3N5O/c22-21(23,24)16-3-1-2-13(4-16)5-17(25)12-30-18-6-14(8-26-10-18)19-7-15-9-28-29-20(15)11-27-19/h1-4,6-11,17H,5,12,25H2,(H,28,29)/t17-/m0/s1
  • InChiKey: OZPLURSGGRWIKB-KRWDZBQOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-1-[[5-(1H-pyrazolo[3,4-c]pyridin-5-yl)-3-pyridyl]oxy]-3-[3-(trifluoromethyl)phenyl]propan-2-amine
  • (2S)-1-[[5-(1H-pyrazolo[3,4-c]pyridin-5-yl)-3-pyridyl]oxy]-3-[3-(trifluoromethyl)phenyl]-2-propanamine
  • [(1S)-1-[[5-(1H-pyrazolo[3,4-c]pyridin-5-yl)-3-pyridyl]oxymethyl]-2-[3-(trifluoromethyl)phenyl]ethyl]amine
  • (2S)-1-[5-(1H-pyrazolo[4,3-d]pyridin-5-yl)pyridin-3-yl]oxy-3-[3-(trifluoromethyl)phenyl]propan-2-amine
  • (2S)-1-[[5-(1H-pyrazolo[4,3-d]pyridin-5-yl)-3-pyridyl]oxy]-3-[3-(trifluoromethyl)phenyl]propan-2-amine
  • [(1S)-1-[[5-(1H-pyrazolo[4,3-d]pyridin-5-yl)-3-pyridyl]oxymethyl]-2-[3-(trifluoromethyl)phenyl]ethyl]amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase, cAMP-dependent, catalytic, beta References
Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha References
Homo sapiens v-akt murine thymoma viral oncogene homolog 1 Starlite/ChEMBL References
Homo sapiens protein kinase, cAMP-dependent, catalytic, gamma Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma congolense rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva cAMP-dependent protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase 2, putative Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium yoelii kinase Akt/PKB-related Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi p70 ribosomal S6 kinase beta Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma congolense protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans likely protein kinase similar to S. cerevisiae YPK2 (YMR104C) Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K08792 serum/glucocorticoid regulated kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Cryptosporidium parvum protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K04456 RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania infantum protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium knowlesi RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K07390 monothiol glutaredoxin, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Protein kinase DC2, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/AKT protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei protein kinase A catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/RSK/P70 protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus serine threonine protein kinase nrc Get druggable targets OG5_126635 All targets in OG5_126635
Neospora caninum Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium berghei rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus calcium:calmodulin dependent protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium vivax rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania infantum protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium knowlesi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi Protein kinase B Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii AGC kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium falciparum RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium berghei cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Cryptosporidium hominis protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis rac serine:threonine kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania major protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania braziliensis protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei protein lipid droplet kinase (LDK) protein kinase, cAMP-dependent, catalytic, beta 358 aa 320 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0146 0.9815 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.0042 0.2031 0.2069
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0146 0.9815 1
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0144 0.967 0.9852
Schistosoma mansoni serine/threonine-protein kinase 0.0029 0.1089 0.111
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0027 0.0904 0.0921
Loa Loa (eye worm) AGC/PKA protein kinase 0.0146 0.9815 1
Trichomonas vaginalis AGC family protein kinase 0.0042 0.2031 0.2069
Trypanosoma cruzi Protein kinase B 0.0029 0.1089 0.0207
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0146 0.9815 1
Trichomonas vaginalis AGC family protein kinase 0.0146 0.9815 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0039 0.1846 0.1881
Entamoeba histolytica PH domain containing protein kinase, putative 0.0149 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.9815 1
Trichomonas vaginalis AGC family protein kinase 0.0042 0.2031 0.2069
Schistosoma mansoni serine/threonine-protein kinase 0.0029 0.1089 0.111
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0039 0.1846 0.1881
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.9815 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0146 0.9815 1
Leishmania major protein kinase A catalytic subunit 0.0146 0.9815 0.5
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0146 0.9815 1
Trichomonas vaginalis AGC family protein kinase 0.0042 0.2031 0.2069
Echinococcus multilocularis Glutaredoxin protein 5 0.0025 0.0759 0.0773
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0146 0.9815 1
Trichomonas vaginalis AGC family protein kinase 0.0042 0.2031 0.2069
Toxoplasma gondii AGC kinase 0.0146 0.9815 1
Toxoplasma gondii AGC kinase 0.0146 0.9815 1
Echinococcus granulosus serine threonine protein kinase nrc 0.0027 0.0904 0.0921
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0027 0.0904 0.0921
Echinococcus granulosus serine/threonine protein kinase 0.0029 0.1089 0.111
Loa Loa (eye worm) hypothetical protein 0.0146 0.9815 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0146 0.9815 1
Echinococcus granulosus nervana 2 0.0025 0.0759 0.0773
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0146 0.9815 1
Entamoeba histolytica protein kinase, putative 0.0039 0.1846 0.1846
Leishmania major protein kinase A catalytic subunit isoform 1 0.0146 0.9815 0.5
Echinococcus multilocularis rac serine:threonine kinase 0.0029 0.1089 0.111
Trichomonas vaginalis AGC family protein kinase 0.0042 0.2031 0.2069
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0185 0.0188
Brugia malayi Protein kinase domain containing protein 0.0042 0.2031 0.2069
Leishmania major protein kinase A catalytic subunit isoform 2 0.0146 0.9815 0.5
Echinococcus multilocularis nervana 2 0.0025 0.0759 0.0773
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0146 0.9815 1
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0144 0.967 0.9852
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0146 0.9815 1
Entamoeba histolytica protein kinase 2, putative 0.0027 0.0904 0.0904
Echinococcus granulosus nervana 2 0.0025 0.0759 0.0773
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0146 0.9815 1
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0146 0.9815 1
Loa Loa (eye worm) AGC/PKA protein kinase 0.0146 0.9815 1
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.9815 1
Entamoeba histolytica protein kinase, putative 0.0042 0.2031 0.2031
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0025 0.0759 0.0773
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0146 0.9815 1
Echinococcus granulosus Glutaredoxin protein 5 0.0025 0.0759 0.0773
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0146 0.9815 1
Trichomonas vaginalis AGC family protein kinase 0.0042 0.2031 0.2069
Entamoeba histolytica PH domain containing protein kinase, putative 0.0029 0.1089 0.1089
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0146 0.9815 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0146 0.9815 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0029 0.1089 0.1089
Entamoeba histolytica protein kinase, putative 0.0042 0.2031 0.2031
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0146 0.9815 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0025 0.0759 0.0773
Echinococcus multilocularis nervana 2 0.0025 0.0759 0.0773
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0146 0.9815 1
Giardia lamblia Kinase, AGC PKA 0.0146 0.9815 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0029 0.1089 0.0207
Trichomonas vaginalis AGC family protein kinase 0.0042 0.2031 0.2069

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 2.39 uM Cytotoxicity against human MiaPaCa cells by MTT assay ChEMBL. 17523610
IC50 (binding) = 7.2 nM Inhibition of human Akt1 ChEMBL. 17523610
IC50 (binding) = 7.2 nM Inhibition of human Akt1 ChEMBL. 17523610
IC50 (binding) = 78 nM Inhibition of PKA ChEMBL. 17523610
IC50 (binding) = 78 nM Inhibition of PKA ChEMBL. 17523610

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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