Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Magnaporthe oryzae (strain 70-15 / FGSC 8958) (Rice blast fungus)(Pyricularia oryzae) | Isocitrate lyase | Starlite/ChEMBL | References |
Homo sapiens | arachidonate 15-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium leprae | Isocitrate lyase | Isocitrate lyase | 547 aa | 536 aa | 35.4 % |
Echinococcus granulosus | arachidonate 5 lipoxygenase | arachidonate 15-lipoxygenase | 662 aa | 590 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0488 | 0.5371 | 0.5371 |
Loa Loa (eye worm) | hypothetical protein | 0.0488 | 0.5371 | 0.5371 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0627 | 0.8223 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0714 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0714 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0714 | 1 | 1 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0627 | 0.8223 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0226 | 0 | 0.5 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0627 | 0.8223 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0226 | 0 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0226 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0488 | 0.5371 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0226 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0226 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) | 0.0627 | 0.8223 | 1 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0627 | 0.8223 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0226 | 0 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0627 | 0.8223 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Reduction of appressorium formation in wild type Magnaporthe grisea Guy 11 after 14 hrs | ChEMBL. | 17317180 |
IC50 (binding) | Inhibition of His-tagged human platelet 12-lipoxygenase | ChEMBL. | 12608855 | |
IC50 (binding) | = 0.5 uM | Inhibition of His-tagged human reticulocyte 15-lipoxygenase | ChEMBL. | 12608855 |
IC50 (binding) | = 15 uM | Inhibition of Magnaporthe grisea Guy 11 isocitrate lyase | ChEMBL. | 17317180 |
IC50 (binding) | = 15 uM | Inhibition of Magnaporthe grisea Guy 11 isocitrate lyase | ChEMBL. | 17317180 |
IC50 (binding) | = 273.6 uM | Inhibition of Magnaporthe grisea Guy 11 malate synthase | ChEMBL. | 17317180 |
MIC (functional) | = 105.4 uM | Growth inhibition of Magnaporthe grisea Guy 11 in presence of sodium acetate after 6 days | ChEMBL. | 17317180 |
MIC (functional) | = 842.8 uM | Growth inhibition of Magnaporthe grisea Guy 11 in presence of glucose after 6 days | ChEMBL. | 17317180 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.