Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.9201 | 0.9201 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0183 | 0.9201 | 0.9201 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0183 | 0.9201 | 0.9201 |
Schistosoma mansoni | thyroid hormone receptor | 0.0183 | 0.9201 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0086 | 0.2623 | 0.2623 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0097 | 0.3327 | 0.3327 |
Echinococcus granulosus | geminin | 0.0162 | 0.7799 | 0.7869 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0183 | 0.9201 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0086 | 0.2623 | 0.2623 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3327 | 0.3327 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0183 | 0.9201 | 0.9201 |
Brugia malayi | hypothetical protein | 0.0097 | 0.3327 | 0.3327 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0086 | 0.2623 | 0.2623 |
Brugia malayi | nuclear receptor RXR | 0.0097 | 0.3327 | 0.3327 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0086 | 0.2623 | 0.2623 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0183 | 0.9201 | 0.9201 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0183 | 0.9201 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0183 | 0.9201 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2623 | 0.2623 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0183 | 0.9201 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0183 | 0.9201 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0183 | 0.9201 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0183 | 0.9201 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2623 | 0.2623 |
Echinococcus granulosus | FTZ F1 alpha | 0.0183 | 0.9201 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2623 | 0.2623 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0162 | 0.7778 | 0.7836 |
Brugia malayi | nuclear receptor RXR | 0.0086 | 0.2623 | 0.2623 |
Loa Loa (eye worm) | DR-78 | 0.0086 | 0.2623 | 0.2623 |
Brugia malayi | hypothetical protein | 0.0097 | 0.3327 | 0.3327 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0086 | 0.2623 | 0.2623 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0097 | 0.3327 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2623 | 0.2623 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2623 | 0.2623 |
Brugia malayi | conserved hypotetical protein | 0.0086 | 0.2623 | 0.2623 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0097 | 0.3327 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2623 | 0.2623 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0183 | 0.9201 | 0.9201 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.9201 | 0.9201 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0183 | 0.9201 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0086 | 0.2623 | 0.2623 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0183 | 0.9201 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2623 | 0.2623 |
Brugia malayi | ecdysteroid receptor | 0.0183 | 0.9201 | 0.9201 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0183 | 0.9201 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0183 | 0.9201 | 0.9201 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0086 | 0.2623 | 0.2623 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0097 | 0.3327 | 0.3327 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.7799 | 0.7869 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.9201 | 0.9201 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2623 | 0.2623 |
Schistosoma mansoni | nuclear hormone receptor | 0.0183 | 0.9201 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0183 | 0.9201 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0183 | 0.9201 | 0.9201 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0183 | 0.9201 | 0.9201 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0183 | 0.9201 | 0.9201 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0183 | 0.9201 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0086 | 0.2623 | 0.2623 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0183 | 0.9201 | 0.9201 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0183 | 0.9201 | 0.9201 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0183 | 0.9201 | 0.9201 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3327 | 0.3327 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0183 | 0.9201 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0183 | 0.9201 | 0.9201 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0097 | 0.3327 | 0.3327 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0183 | 0.9201 | 0.9201 |
Brugia malayi | nuclear hormone receptor | 0.0086 | 0.2623 | 0.2623 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.9201 | 0.9201 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0183 | 0.9201 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0162 | 0.7778 | 0.7836 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2623 | 0.2623 |
Brugia malayi | tailless protein | 0.0086 | 0.2623 | 0.2623 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0183 | 0.9201 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0183 | 0.9201 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3327 | 0.3327 |
Brugia malayi | hypothetical protein | 0.0086 | 0.2623 | 0.2623 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0183 | 0.9201 | 0.9201 |
Brugia malayi | steroid hormone receptor | 0.0183 | 0.9201 | 0.9201 |
Brugia malayi | nuclear receptor NHR-88 | 0.0183 | 0.9201 | 0.9201 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0183 | 0.9201 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0086 | 0.2623 | 0.2623 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0086 | 0.2623 | 0.2623 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0183 | 0.9201 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0183 | 0.9201 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.9201 | 0.9201 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0183 | 0.9201 | 1 |
Brugia malayi | ecdysone receptor | 0.0086 | 0.2623 | 0.2623 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2623 | 0.2623 |
Onchocerca volvulus | 0.0183 | 0.9201 | 1 | |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0183 | 0.9201 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3327 | 0.3327 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0183 | 0.9201 | 0.9201 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0183 | 0.9201 | 0.9201 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0183 | 0.9201 | 0.9201 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2623 | 0.2623 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0183 | 0.9201 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0183 | 0.9201 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.9201 | 0.9201 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0183 | 0.9201 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0097 | 0.3327 | 0.1071 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0183 | 0.9201 | 0.9201 |
Echinococcus multilocularis | geminin | 0.0162 | 0.7799 | 0.7869 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0183 | 0.9201 | 0.9201 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.9201 | 0.9201 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0183 | 0.9201 | 0.9201 |
Brugia malayi | hypothetical protein | 0.0086 | 0.2623 | 0.2623 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0097 | 0.3327 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0183 | 0.9201 | 0.9201 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0183 | 0.9201 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3327 | 0.3327 |
Brugia malayi | nuclear receptor NHR-67 | 0.0086 | 0.2623 | 0.2623 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2623 | 0.2623 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0183 | 0.9201 | 0.9201 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.9201 | 0.9201 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0183 | 0.9201 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0183 | 0.9201 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0183 | 0.9201 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0183 | 0.9201 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0183 | 0.9201 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.7799 | 0.7869 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0183 | 0.9201 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2623 | 0.2623 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0183 | 0.9201 | 0.9201 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0183 | 0.9201 | 0.9201 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 2.5 ug/hr.ml | AUC in rat at 1 mg/kg, iv | ChEMBL. | 17303420 |
CL (ADMET) | = 33 ml/min.kg | Clearance in rat at 1 mg/kg, iv | ChEMBL. | 17303420 |
Cmax (ADMET) | = 0.3 ug ml-1 | Cmax in rat at 5 mg/kg, po | ChEMBL. | 17303420 |
F (ADMET) | = 18 % | Bioavailability in rat at 5 mg/kg, po | ChEMBL. | 17303420 |
Ki (binding) | = 112 uM | Displacement of [3H]dofetilide from human ERG by fliter binding assay | ChEMBL. | 17303420 |
Ki (binding) | = 112 uM | Displacement of [3H]dofetilide from human ERG by fliter binding assay | ChEMBL. | 17303420 |
MIC (functional) | = 0.015 ug ml-1 | Antibacterial activity against Haemophilus influenzae HI-3542 | ChEMBL. | 17303420 |
MIC (functional) | = 0.06 ug ml-1 | Antibacterial activity against Staphylococcus aureus UC76 | ChEMBL. | 17303420 |
MIC (functional) | = 0.06 ug ml-1 | Antibacterial activity against Staphylococcus aureus SA2552 | ChEMBL. | 17303420 |
MIC (functional) | = 0.06 ug ml-1 | Antibacterial activity against Streptococcus pneumoniae SV1 | ChEMBL. | 17303420 |
MIC (functional) | = 0.06 ug ml-1 | Antibacterial activity against Moraxella catarrhalis BC-3531 | ChEMBL. | 17303420 |
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against fluoroquinolone resistance Streptococcus pneumoniae SP3765 | ChEMBL. | 17303420 |
t1/2 (ADMET) | = 1.3 hr | Half life in rat at 1 mg/kg, iv | ChEMBL. | 17303420 |
Vdss (ADMET) | = 2.5 L/Kg | Volume of distribution in rat at 1 mg/kg, iv | ChEMBL. | 17303420 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.