TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 454.946 | Formula: C25H27ClN2O4
H donors: 0 H acceptors: 2 LogP: 4.21 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)c(CCCC(=O)N1CCOCC1)c(n2C(=O)c1ccc(cc1)Cl)C
InChi: 1S/C25H27ClN2O4/c1-17-21(4-3-5-24(29)27-12-14-32-15-13-27)22-16-20(31-2)10-11-23(22)28(17)25(30)18-6-8-19(26)9-7-18/h6-11,16H,3-5,12-15H2,1-2H3
InChiKey: XPBPUSUVGMNYAH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Arachidonate 5-lipoxygenase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma mansoni	lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma japonicum	IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing	Get druggable targets OG5_127482	All targets in OG5_127482
Echinococcus multilocularis	arachidonate 5 lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma mansoni	lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Echinococcus granulosus	arachidonate 5 lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.014	0.0397	0.0826
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Schistosoma mansoni	biogenic amine receptor	0.0097	0.0084	0.0205
Echinococcus multilocularis	orexin receptor type 2	0.0097	0.0084	0.0323
Echinococcus multilocularis	nervana 2	0.0441	0.2617	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0365	0.2056	0.7856
Brugia malayi	G protein-coupled receptor F59B2.13	0.0097	0.0084	0.0084
Schistosoma mansoni	growth hormone secretagogue receptor	0.0097	0.0084	0.0205
Brugia malayi	Integrin alpha pat-2 precursor	0.015	0.0472	0.0472
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0097	0.0084	0.0084
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0097	0.0084	0.0084
Echinococcus multilocularis	nervana 2	0.0365	0.2056	0.7856
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.015	0.0474	0.0474
Schistosoma mansoni	cercarial elastase (S01 family)	0.0094	0.0063	0.0153
Loa Loa (eye worm)	G-protein coupled receptor	0.0097	0.0084	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0365	0.2056	0.5003
Echinococcus multilocularis	neuropeptide receptor	0.0247	0.1185	0.4527
Echinococcus granulosus	biogenic amine 5HT receptor	0.0097	0.0084	0.0323
Schistosoma mansoni	biogenic amine receptor	0.0097	0.0084	0.0205
Schistosoma mansoni	na+/k+ atpase alpha subunit	0.0225	0.1027	0.2498
Brugia malayi	Trypsin family protein	0.0094	0.0063	0.0063
Brugia malayi	Na,K-ATPase alpha subunit	0.0225	0.1027	0.1027
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0097	0.0084	0.0205
Brugia malayi	hypothetical protein	0.0094	0.0063	0.0063
Brugia malayi	Serotonin receptor	0.0097	0.0084	0.0084
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.015	0.0474	0.1015
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0097	0.0084	0.0323
Schistosoma mansoni	opsin-like receptor	0.0097	0.0084	0.0205
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.0084	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0097	0.0084	0.0323
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0097	0.0084	0.0205
Loa Loa (eye worm)	melatonin receptor type 1A	0.0097	0.0084	0.0053
Entamoeba histolytica	protein kinase, putative	0.0115	0.0215	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.0084	0.0323
Schistosoma mansoni	cercarial elastase (S01 family)	0.0094	0.0063	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Schistosoma mansoni	cercarial elastase (S01 family)	0.0094	0.0063	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus granulosus	hypothetical protein	0.0097	0.0084	0.0323
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0097	0.0084	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0441	0.2617	0.6312
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus multilocularis	somatostatin receptor	0.0097	0.0084	0.0323
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.0084	0.0205
Brugia malayi	Trypsin family protein	0.0094	0.0063	0.0063
Brugia malayi	neuropeptide F receptor	0.0097	0.0084	0.0084
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0644	0.411	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0097	0.0084	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0644	0.411	1
Onchocerca volvulus		0.0365	0.2056	0.4925
Schistosoma mansoni	histamine h1 receptor	0.0097	0.0084	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus granulosus	neuropeptide Y receptor	0.0097	0.0084	0.0323
Onchocerca volvulus		0.0217	0.0969	0.2238
Brugia malayi	hypothetical protein	0.0097	0.0084	0.0084
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0097	0.0084	0.0053
Schistosoma mansoni	adenoreceptor	0.0097	0.0084	0.0205
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.0194	0.0798	0.0798
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0094	0.0063	0.0153
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.0084	0.0205
Echinococcus granulosus	sodium:potassium transporting ATPase subunit	0.0441	0.2617	1
Brugia malayi	Dopamine receptor protein 1	0.0097	0.0084	0.0084
Trichomonas vaginalis	AGC family protein kinase	0.0115	0.0215	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Brugia malayi	serine/threonine protein kinase 6	0.0115	0.0215	0.0215
Schistosoma mansoni	protein kinase	0.0115	0.0215	0.0522
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0441	0.2617	1
Brugia malayi	G-protein coupled receptor	0.0097	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.015	0.0474	0.1015
Onchocerca volvulus		0.0441	0.2617	0.6312
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus multilocularis	neuropeptide receptor	0.0097	0.0084	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus granulosus	g protein coupled receptor	0.0097	0.0084	0.0323
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0097	0.0084	0.0205
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0097	0.0084	0.0205
Onchocerca volvulus		0.0097	0.0084	0.0053
Echinococcus multilocularis	neuropeptide Y receptor	0.0097	0.0084	0.0323
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0094	0.0063	0.024
Echinococcus granulosus	biogenic amine 5HT receptor	0.0097	0.0084	0.0323
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.0084	0.0323
Echinococcus granulosus	tm gpcr rhodopsin	0.0097	0.0084	0.0323
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0254	0.1237	0.3011
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0097	0.0084	0.0323
Echinococcus granulosus	nervana 2	0.0365	0.2056	0.7856
Echinococcus granulosus	transmembrane protease serine 3	0.0094	0.0063	0.024
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.0084	0.0323
Echinococcus multilocularis	g-protein coupled receptor	0.0097	0.0084	0.0323
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0094	0.0063	0.0153
Loa Loa (eye worm)	TYRA-2 protein	0.0097	0.0084	0.0053
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0097	0.0084	0.0323
Onchocerca volvulus		0.0097	0.0084	0.0053
Echinococcus granulosus	neuropeptide receptor	0.0097	0.0084	0.0323
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0097	0.0084	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Schistosoma mansoni	biogenic amine receptor	0.0097	0.0084	0.0205
Echinococcus granulosus	enteropeptidase	0.0094	0.0063	0.024
Onchocerca volvulus		0.0644	0.411	1
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0235	0.0426
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0097	0.0084	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus granulosus	neuropeptide receptor A26	0.0097	0.0084	0.0323
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.0084	0.0205
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0441	0.2617	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0097	0.0084	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.0084	0.0323
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0094	0.0063	0.024
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0097	0.0084	0.0205
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.0084	0.0323
Schistosoma mansoni	cercarial elastase (S01 family)	0.0094	0.0063	0.0153
Echinococcus multilocularis	Mastin	0.0094	0.0063	0.024
Mycobacterium ulcerans	metal cation transporter p-type ATPase a	0.0217	0.0969	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0097	0.0084	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0657	0.1468
Entamoeba histolytica	protein kinase , putative	0.0115	0.0215	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0097	0.0084	0.0053
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0115	0.0215	0.082
Echinococcus granulosus	serotonin receptor	0.0097	0.0084	0.0323
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0097	0.0084	0.0323
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0097	0.0084	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus multilocularis	serotonin receptor	0.0097	0.0084	0.0323
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0097	0.0084	0.0323
Brugia malayi	putative neuropeptide receptor NPR1	0.0097	0.0084	0.0084
Schistosoma mansoni	cercarial elastase (S01 family)	0.0094	0.0063	0.0153
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.0084	0.0323
Echinococcus multilocularis	nervana 2	0.0365	0.2056	0.7856
Echinococcus granulosus	sex peptide receptor	0.0097	0.0084	0.0323
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.015	0.0474	0.181
Schistosoma mansoni	lipoxygenase	0.0142	0.0418	0.1017
Schistosoma mansoni	amine GPCR	0.0097	0.0084	0.0205
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0097	0.0084	0.0084
Schistosoma mansoni	cercarial elastase (S01 family)	0.0094	0.0063	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.0225	0.1027	0.2382
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0097	0.0084	0.0323
Brugia malayi	Cation transporter family protein	0.0254	0.1237	0.1237
Echinococcus granulosus	nervana 2	0.0441	0.2617	1
Brugia malayi	follicle stimulating hormone receptor	0.0097	0.0084	0.0084
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0441	0.2617	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Schistosoma mansoni	serine/threonine protein kinase	0.0115	0.0215	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0097	0.0084	0.0323
Brugia malayi	hypothetical protein	0.0097	0.0084	0.0084
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0115	0.0215	0.082
Onchocerca volvulus	Putative nachr subunit	0.015	0.0474	0.1015
Onchocerca volvulus		0.0254	0.1237	0.2902
Echinococcus granulosus	Mastin	0.0094	0.0063	0.024
Echinococcus multilocularis	glycoprotein Antigen 5	0.0094	0.0063	0.024
Echinococcus granulosus	fmrfamide receptor	0.0097	0.0084	0.0323
Schistosoma mansoni	hypothetical protein	0.0097	0.0084	0.0205
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0097	0.0084	0.0323
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0097	0.0084	0.0053
Brugia malayi	AKH receptor	0.0097	0.0084	0.0084
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0097	0.0084	0.0205
Brugia malayi	G protein-coupled receptor	0.0097	0.0084	0.0084
Echinococcus granulosus	neuropeptide receptor	0.0247	0.1185	0.4527
Loa Loa (eye worm)	AUR protein kinase	0.0115	0.0215	0.0375
Loa Loa (eye worm)	AUR protein kinase	0.0115	0.0215	0.0375
Brugia malayi	larval opioid receptor	0.0097	0.0084	0.0084
Onchocerca volvulus		0.0097	0.0084	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Trypanosoma brucei	aurora B kinase	0.0115	0.0215	1
Schistosoma mansoni	opsin-like receptor	0.0097	0.0084	0.0205
Echinococcus multilocularis	Na+:K+ ATPase alpha subunit	0.0225	0.1027	0.3923
Brugia malayi	hypothetical protein	0.0097	0.0084	0.0084
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.0084	0.0205
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0097	0.0084	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Onchocerca volvulus		0.0097	0.0084	0.0053
Brugia malayi	Dopamine receptor protein 2	0.0097	0.0084	0.0084
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0097	0.0084	0.0323
Onchocerca volvulus		0.0097	0.0084	0.0053
Schistosoma mansoni	hypothetical protein	0.0097	0.0084	0.0205
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0094	0.0063	0.0153
Schistosoma mansoni	myosin xvIII	0.0097	0.0084	0.0205
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0097	0.0084	0.0084
Echinococcus granulosus	dro:myosuppressin receptor	0.0097	0.0084	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Schistosoma mansoni	lipoxygenase	0.01	0.0103	0.025
Schistosoma mansoni	neuropeptide receptor	0.0097	0.0084	0.0205
Echinococcus granulosus	g protein coupled receptor	0.0097	0.0084	0.0323
Onchocerca volvulus		0.0097	0.0084	0.0053
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0097	0.0084	0.0205
Onchocerca volvulus		0.0097	0.0084	0.0053
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0097	0.0084	0.0205
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.0084	0.0323
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0097	0.0084	0.0053
Trypanosoma cruzi	aurora B kinase, putative	0.0115	0.0215	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0094	0.0063	0.0153
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0097	0.0084	0.0323
Echinococcus granulosus	aurora kinase A	0.0115	0.0215	0.082
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.0084	0.0205
Echinococcus granulosus	g-protein coupled receptor	0.0097	0.0084	0.0323
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0097	0.0084	0.0205
Echinococcus multilocularis	neuropeptides capa receptor	0.0097	0.0084	0.0323
Onchocerca volvulus		0.0097	0.0084	0.0053
Schistosoma mansoni	amine GPCR	0.0097	0.0084	0.0205
Onchocerca volvulus		0.0097	0.0084	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0204	0.0348
Schistosoma mansoni	neuropeptide f receptor 76f	0.0097	0.0084	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0254	0.1237	0.2902
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.015	0.0474	0.181
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Schistosoma mansoni	integrin alpha	0.015	0.0472	0.1149
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.0084	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Entamoeba histolytica	protein kinase domain containing protein	0.0115	0.0215	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0097	0.0084	0.0323
Echinococcus multilocularis	allatostatin A receptor	0.0097	0.0084	0.0323
Schistosoma mansoni	amine GPCR	0.0097	0.0084	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Schistosoma mansoni	neuropeptide F-like receptor	0.0097	0.0084	0.0205
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0097	0.0084	0.0323
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.0084	0.0205
Onchocerca volvulus		0.0097	0.0084	0.0053
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0097	0.0084	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0151	0.048	0.1031
Echinococcus granulosus	7tm_1 domain containing protein	0.0097	0.0084	0.0323
Schistosoma mansoni	transmemberane protein	0.0441	0.2617	0.6368
Echinococcus multilocularis	aurora kinase A	0.0115	0.0215	0.082
Onchocerca volvulus		0.0097	0.0084	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Loa Loa (eye worm)	AUR protein kinase	0.0115	0.0215	0.0375
Echinococcus granulosus	nervana 2	0.0441	0.2617	1
Onchocerca volvulus		0.055	0.3417	0.8289
Entamoeba histolytica	protein kinase, putative	0.0115	0.0215	1
Schistosoma mansoni	hypothetical protein	0.0094	0.0063	0.0153
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0142	0.0418	0.1597
Echinococcus multilocularis	g protein coupled receptor	0.0097	0.0084	0.0323
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0094	0.0063	0.024
Onchocerca volvulus		0.0097	0.0084	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Onchocerca volvulus		0.0097	0.0084	0.0053
Echinococcus granulosus	allatostatin A receptor	0.0097	0.0084	0.0323
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0097	0.0084	0.0053
Brugia malayi	Serotonin receptor	0.0097	0.0084	0.0084
Onchocerca volvulus		0.0254	0.1237	0.2902
Schistosoma mansoni	hypothetical protein	0.0097	0.0084	0.0205
Brugia malayi	hypothetical protein	0.0097	0.0084	0.0084
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0097	0.0084	0.0323
Mycobacterium ulcerans	hypothetical protein	0.0094	0.0063	0.0649
Schistosoma mansoni	hypothetical protein	0.0094	0.0063	0.0153
Schistosoma mansoni	cercarial elastase (S01 family)	0.0094	0.0063	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0254	0.1237	0.2902
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0441	0.2617	1
Trichomonas vaginalis	AGC family protein kinase	0.0115	0.0215	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.0084	0.0323
Toxoplasma gondii	PAN domain-containing protein	0.0883	0.5861	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.0084	0.0323
Echinococcus multilocularis	sex peptide receptor	0.0097	0.0084	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0225	0.1027	0.2382
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0094	0.0063	0.024
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0097	0.0084	0.0053
Schistosoma mansoni	cercarial elastase (S01 family)	0.0094	0.0063	0.0153
Onchocerca volvulus		0.0097	0.0084	0.0053
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0097	0.0084	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0142	0.0418	0.1597
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0094	0.0063	0.0153
Schistosoma mansoni	opsin-like receptor	0.0097	0.0084	0.0205
Loa Loa (eye worm)	integrin alpha pat-2	0.0231	0.1069	0.2485
Echinococcus multilocularis	neuropeptide s receptor	0.0097	0.0084	0.0323
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.0084	0.0205
Brugia malayi	hypothetical protein	0.0097	0.0084	0.0084
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0113	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0441	0.2617	0.6312
Schistosoma mansoni	neuropeptide receptor	0.0097	0.0084	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Leishmania major	protein kinase, putative	0.0115	0.0215	1
Schistosoma mansoni	amine GPCR	0.0097	0.0084	0.0205
Echinococcus multilocularis	fmrfamide receptor	0.0097	0.0084	0.0323
Echinococcus multilocularis	transmembrane protease serine 3	0.0094	0.0063	0.024
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0094	0.0063	0.0153
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0097	0.0084	0.0205
Echinococcus granulosus	neuropeptide Y receptor	0.0097	0.0084	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.0084	0.0323
Echinococcus granulosus	neuropeptide s receptor	0.0097	0.0084	0.0323
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0097	0.0084	0.0323
Echinococcus multilocularis	fmrfamide receptor	0.0097	0.0084	0.0323
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0097	0.0084	0.0205
Brugia malayi	hypothetical protein	0.0097	0.0084	0.0084
Toxoplasma gondii	aurora kinase	0.0115	0.0215	0.0366
Brugia malayi	ORL1-like opioid receptor	0.0097	0.0084	0.0084
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.0084	0.0323
Echinococcus multilocularis	integrin alpha 3	0.0115	0.0215	0.0822
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0097	0.0084	0.0323
Echinococcus granulosus	neuropeptide FF receptor 2	0.0097	0.0084	0.0323
Onchocerca volvulus		0.0254	0.1237	0.2902
Brugia malayi	Trypsin family protein	0.0644	0.411	0.411
Schistosoma mansoni	amine GPCR	0.0097	0.0084	0.0205
Schistosoma mansoni	neuropeptide F-like receptor	0.0097	0.0084	0.0205
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.0084	0.0323
Brugia malayi	hypothetical protein	0.0097	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0365	0.2056	0.7856
Brugia malayi	serine/threonine-protein kinase 6	0.0115	0.0215	0.0215
Brugia malayi	hypothetical protein	0.0097	0.0084	0.0084
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0115	0.0215	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0097	0.0084	0.0323
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.0084	0.0323
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0097	0.0084	0.0053
Echinococcus multilocularis	g protein coupled receptor	0.0097	0.0084	0.0323
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0097	0.0084	0.0205
Brugia malayi	G-protein coupled receptor	0.0097	0.0084	0.0084
Schistosoma mansoni	cercarial elastase (S01 family)	0.0094	0.0063	0.0153
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0097	0.0084	0.0323
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0254	0.1237	0.3011
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0097	0.0084	0.0084
Schistosoma mansoni	cercarial elastase (S01 family)	0.0094	0.0063	0.0153
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0225	0.1027	0.2498
Brugia malayi	sulfakinin receptor protein	0.0097	0.0084	0.0084
Brugia malayi	Trypsin-like protease protein 5	0.0094	0.0063	0.0063
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.0194	0.0798	0.1816
Brugia malayi	hypothetical protein	0.0097	0.0084	0.0084
Brugia malayi	RE15519p	0.0097	0.0084	0.0084
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0644	0.411	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0097	0.0084	0.0053
Echinococcus granulosus	neuropeptides capa receptor	0.0097	0.0084	0.0323
Schistosoma mansoni	sodium / potassium ATPase beta chain	0.0365	0.2056	0.5003
Echinococcus granulosus	neuropeptides capa receptor	0.0097	0.0084	0.0323
Brugia malayi	neuropeptide F receptor	0.0097	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Trichomonas vaginalis	AGC family protein kinase	0.0115	0.0215	1
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0115	0.0215	1
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0115	0.0215	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.0084	0.0323
Echinococcus multilocularis	G protein coupled receptor 139	0.0247	0.1185	0.4527
Echinococcus granulosus	somatostatin receptor	0.0097	0.0084	0.0323
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0441	0.2617	0.6368
Echinococcus granulosus	nervana 2	0.0365	0.2056	0.7856
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.015	0.0474	0.181
Echinococcus multilocularis	g protein coupled receptor	0.0097	0.0084	0.0323
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0094	0.0063	0.0063
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0115	0.0215	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Schistosoma mansoni	cercarial elastase (S01 family)	0.0094	0.0063	0.0153
Echinococcus multilocularis	enteropeptidase	0.0094	0.0063	0.024
Echinococcus granulosus	G protein coupled receptor 139	0.0097	0.0084	0.0323
Echinococcus granulosus	glycoprotein Antigen 5	0.0094	0.0063	0.024
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.015	0.0474	0.181
Brugia malayi	putative neuropeptide receptor	0.0097	0.0084	0.0084
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.015	0.0474	0.181
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.0084	0.0205
Brugia malayi	hypothetical protein	0.0097	0.0084	0.0084
Toxoplasma gondii	PAN domain-containing protein	0.0883	0.5861	1
Echinococcus granulosus	Na:K ATPase alpha subunit	0.0225	0.1027	0.3923
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0097	0.0084	0.0323
Onchocerca volvulus		0.0097	0.0084	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.015	0.0474	0.181
Brugia malayi	serine/threonine kinase 12	0.0115	0.0215	0.0215
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0097	0.0084	0.0323
Echinococcus granulosus	tm gpcr rhodopsin	0.0097	0.0084	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0644	0.411	1
Echinococcus granulosus	g protein coupled receptor	0.0097	0.0084	0.0323
Echinococcus multilocularis	serotonin receptor	0.0097	0.0084	0.0323
Echinococcus multilocularis	nervana 2	0.0441	0.2617	1
Onchocerca volvulus		0.0097	0.0084	0.0053
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0097	0.0084	0.0205
Echinococcus multilocularis	neuropeptides capa receptor	0.0097	0.0084	0.0323
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0097	0.0084	0.0084
Echinococcus multilocularis	neuropeptide receptor A26	0.0097	0.0084	0.0323
Brugia malayi	Dopamine receptor	0.0097	0.0084	0.0084
Giardia lamblia	Potassium-transporting ATPase alpha chain 1	0.0225	0.1027	1
Loa Loa (eye worm)	hypothetical protein	0.0217	0.0966	0.2232
Onchocerca volvulus		0.0097	0.0084	0.0053
Brugia malayi	Trypsin family protein	0.0094	0.0063	0.0063
Schistosoma mansoni	hypothetical protein	0.0097	0.0084	0.0205
Echinococcus multilocularis	sodium:potassium transporting ATPase subunit	0.0441	0.2617	1
Echinococcus granulosus	integrin alpha 3	0.0115	0.0215	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Schistosoma mansoni	neuropeptide receptor	0.0247	0.1185	0.2883
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0097	0.0084	0.0205
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0115	0.0215	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Echinococcus granulosus	orexin receptor type 2	0.0097	0.0084	0.0323
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0441	0.2617	0.6368
Trichomonas vaginalis	AGC family protein kinase	0.0115	0.0215	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0084	0.0053
Schistosoma mansoni	neuropeptide receptor	0.0097	0.0084	0.0205
Echinococcus granulosus	tm gpcr rhodopsin	0.0097	0.0084	0.0323
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER ATPASE I CTPI	0.0186	0.074	0.5
Brugia malayi	Melatonin receptor type 1A	0.0097	0.0084	0.0084
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0097	0.0084	0.0323
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0097	0.0084	0.0323

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.25 uM	Inhibition of 5-LOX in rat peritoneal leukocytes	ChEMBL.	17336065
IC50 (binding)	= 2.25 uM	Inhibition of 5-LOX in rat peritoneal leukocytes	ChEMBL.	17336065
Inhibition (binding)	= 70.2 %	Inhibition of 5-LOX in rat peritoneal leukocytes at 5 uM	ChEMBL.	17336065
Inhibition (binding)	= 70.2 %	Inhibition of 5-LOX in rat peritoneal leukocytes at 5 uM	ChEMBL.	17336065

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL230921

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 429327