Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2X, ligand-gated ion channel, 7 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0959 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2551 | 0.2551 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0082 | 0.5721 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3095 | 0.3095 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0959 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3095 | 0.3095 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2551 | 0.2551 |
Schistosoma mansoni | P2X receptor subunit | 0.0082 | 0.5721 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0959 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0959 | 0.1677 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0959 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0959 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0082 | 0.5721 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0959 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3095 | 0.3095 |
Brugia malayi | Hypothetical 112.3 kDa protein K02A2.3 in chromosome II | 0.0049 | 0.3095 | 0.3095 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0959 | 0.0959 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | amino acid permease | 0.0049 | 0.3095 | 0.3095 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2551 | 0.2551 |
Schistosoma mansoni | P2X receptor subunit | 0.0082 | 0.5721 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0959 | 0.1677 |
Echinococcus granulosus | solute carrier family 12 | 0.0049 | 0.3095 | 0.541 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0082 | 0.5721 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0959 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0959 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3095 | 0.3095 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0959 | 0.1677 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0082 | 0.5721 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3095 | 0.3095 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2551 | 0.2551 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0959 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2551 | 0.2551 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0959 | 0.0959 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2551 | 0.2551 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3095 | 0.3095 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0959 | 0.5 |
Echinococcus multilocularis | solute carrier family 12 | 0.0049 | 0.3095 | 0.541 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0959 | 0.1677 |
Schistosoma mansoni | P2X receptor subunit | 0.0082 | 0.5721 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0082 | 0.5721 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0082 | 0.5721 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2551 | 0.2551 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3095 | 0.3095 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0959 | 0.5 |
Schistosoma mansoni | solute carrier family 12 electroneutral k-cl cotransporter | 0.0049 | 0.3095 | 0.541 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0959 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0959 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0959 | 0.5 |
Brugia malayi | Amino acid permease family protein | 0.0049 | 0.3095 | 0.3095 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0082 | 0.5721 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0959 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 1000 nM | Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as effect on intracellular calcium influx | ChEMBL. | 17585854 |
IC50 (functional) | > 1000 nM | Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as effect on intracellular calcium influx | ChEMBL. | 17585854 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.