Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 7 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | serine carboxypeptidase S28, putative | dipeptidyl-peptidase 7 | 492 aa | 471 aa | 25.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0456 | 0.9494 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.028 | 0.4176 | 0.5 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0456 | 0.9494 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.028 | 0.4176 | 0.2884 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.028 | 0.4176 | 0.2884 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0208 | 0.2021 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0208 | 0.2021 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0473 | 1 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0473 | 1 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0473 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0473 | 1 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0473 | 1 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.028 | 0.4176 | 1 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0473 | 1 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0208 | 0.2021 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0208 | 0.2021 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.0473 | 1 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.028 | 0.4176 | 0.2884 |
Mycobacterium ulcerans | peptide deformylase | 0.0473 | 1 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.028 | 0.4176 | 0.5 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0456 | 0.9494 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0208 | 0.2021 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.49 nM | Inhibition of DPP4 | ChEMBL. | 17291750 |
IC50 (binding) | = 1.49 nM | Inhibition of DPP4 | ChEMBL. | 17291750 |
IC50 (binding) | = 6800 nM | Inhibition of QPP | ChEMBL. | 17291750 |
IC50 (binding) | = 6800 nM | Inhibition of QPP | ChEMBL. | 17291750 |
IC50 (binding) | = 19000 nM | Inhibition of DPP8 | ChEMBL. | 17291750 |
IC50 (binding) | = 19000 nM | Inhibition of DPP8 | ChEMBL. | 17291750 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.