Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | phospholipase A1, putative | 0.0717 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0232 | 0.0232 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0232 | 1 |
Toxoplasma gondii | mitochondrial import inner membrane translocase subunit TIM10, putative | 0.005 | 0.0601 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0135 | 0.5844 |
Trypanosoma brucei | phospholipase A1, putative | 0.0717 | 1 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0232 | 1 |
Plasmodium falciparum | mitochondrial import inner membrane translocase subunit TIM10, putative | 0.005 | 0.0601 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0232 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0232 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0232 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0149 | 0.0149 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0149 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0232 | 0.0232 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0232 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.0149 | 0.6421 |
Loa Loa (eye worm) | transport to inner mitochondrial membrane family member | 0.005 | 0.0601 | 0.0601 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0149 | 0.0149 |
Trypanosoma cruzi | phospholipase A2-like protein, putative | 0.0329 | 0.4534 | 0.4534 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0232 | 0.0232 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0149 | 0.6421 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0149 | 0.2474 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0232 | 1 |
Leishmania major | phospholipase A1, putative | 0.0717 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0232 | 0.0232 |
Onchocerca volvulus | 0.0023 | 0.0232 | 0.0232 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0232 | 1 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit TIM10 | 0.005 | 0.0601 | 0.0601 |
Schistosoma mansoni | mitochondrial import inner membrane translocase subunit tim10 | 0.005 | 0.0601 | 1 |
Toxoplasma gondii | TIM10 family protein, putative | 0.005 | 0.0601 | 1 |
Loa Loa (eye worm) | platelet-activating factor acetylhydrolase | 0.0717 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0149 | 0.2474 |
Onchocerca volvulus | 0.0717 | 1 | 1 | |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0232 | 0.0232 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0232 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0149 | 0.0149 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0232 | 0.0232 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0232 | 0.0232 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0232 | 1 |
Echinococcus granulosus | expressed protein | 0.005 | 0.0601 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0232 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0232 | 1 |
Onchocerca volvulus | 0.0717 | 1 | 1 | |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0149 | 0.0149 |
Echinococcus multilocularis | expressed protein | 0.005 | 0.0601 | 1 |
Plasmodium vivax | mitochondrial import inner membrane translocase subunit TIM10, putative | 0.005 | 0.0601 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0135 | 0.5844 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0232 | 1 |
Trypanosoma cruzi | phospholipase A2-like protein, putative | 0.0329 | 0.4534 | 0.4534 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0135 | 0.5844 |
Trypanosoma cruzi | phospholipase A1, putative | 0.0717 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0149 | 0.0149 |
Onchocerca volvulus | 0.0717 | 1 | 1 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0135 | 0.5844 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0232 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0232 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0232 | 0.0232 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 82 % | Displacement of [125I][14Tyr]nociceptin FQ from human cloned NOP receptor expressed in CHO cell membranes at 10 uM | ChEMBL. | 17428659 |
Inhibition (binding) | = 82 % | Displacement of [125I][14Tyr]nociceptin FQ from human cloned NOP receptor expressed in CHO cell membranes at 10 uM | ChEMBL. | 17428659 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.