Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0253 | 0 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.1616 | 0.7397 | 1 |
Schistosoma mansoni | amidase | 0.2096 | 1 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.2096 | 1 | 1 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0253 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.2096 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2096 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1616 | 0.7397 | 1 |
Brugia malayi | Lipase family protein | 0.1616 | 0.7397 | 0.7397 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.2096 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.1616 | 0.7397 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0451 | 0.1076 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.2096 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0451 | 0.1076 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0253 | 0 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.1616 | 0.7397 | 0.7397 |
Onchocerca volvulus | 0.1616 | 0.7397 | 0.5 | |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0253 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1616 | 0.7397 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.2096 | 1 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.1616 | 0.7397 | 0.7397 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1616 | 0.7397 | 1 |
Loa Loa (eye worm) | lipase | 0.1616 | 0.7397 | 0.7397 |
Trypanosoma brucei | lipase domain protein, putative | 0.1616 | 0.7397 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1616 | 0.7397 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0253 | 0 | 0.5 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0253 | 0 | 0.5 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0253 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 69 % | Cytotoxicity against human NCL-H460 cells assessed as growth at 100 uM after 48 hrs by SRB protein assay relative to control | ChEMBL. | 17145120 |
Activity (functional) | = 69 % | Cytotoxicity against human NCL-H460 cells assessed as growth at 100 uM after 48 hrs by SRB protein assay relative to control | ChEMBL. | 17145120 |
Activity (functional) | = 77 % | Cytotoxicity against human SF268 cells assessed as growth at 100 uM after 48 hrs by SRB protein assay relative to control | ChEMBL. | 17145120 |
Activity (functional) | = 77 % | Cytotoxicity against human SF268 cells assessed as growth at 100 uM after 48 hrs by SRB protein assay relative to control | ChEMBL. | 17145120 |
Activity (functional) | = 82 % | Cytotoxicity against human MCF7 cells assessed as growth at 100 uM after 48 hrs by SRB protein assay relative to control | ChEMBL. | 17145120 |
Activity (functional) | = 82 % | Cytotoxicity against human MCF7 cells assessed as growth at 100 uM after 48 hrs by SRB protein assay relative to control | ChEMBL. | 17145120 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.