Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0137 | 0 | 0.5 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0137 | 0 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0595 | 0.4599 | 0.4599 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0595 | 0.4599 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0137 | 0 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0595 | 0.4599 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0595 | 0.4599 | 0.4599 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.1133 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0595 | 0.4599 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0137 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0595 | 0.4599 | 0.5 |
Onchocerca volvulus | 0.0595 | 0.4599 | 0.5 | |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0137 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0152 | 0.0155 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0595 | 0.4599 | 0.4599 |
Leishmania major | hypothetical protein, conserved | 0.0595 | 0.4599 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0152 | 0.0155 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.1133 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1133 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0595 | 0.4599 | 1 |
Brugia malayi | Lipase family protein | 0.0595 | 0.4599 | 0.4599 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.1133 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.1133 | 1 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0595 | 0.4599 | 1 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0137 | 0 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.1133 | 1 | 1 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0137 | 0 | 0.5 |
Schistosoma mansoni | amidase | 0.1133 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.7 uM | Intrinsic binding affinity to Escherichia coli ribosmes by TnT assay | ChEMBL. | 17681758 |
IC50 (functional) | = 1.7 uM | Intrinsic binding affinity to Escherichia coli ribosmes by TnT assay | ChEMBL. | 17681758 |
IC50 (functional) | = 11 uM | Inhibition of mitochondrial protein synthesis in Escherichia coli assessed as [35S]methionine incorporation method | ChEMBL. | 17681758 |
IC50 (functional) | = 11 uM | Inhibition of mitochondrial protein synthesis in Escherichia coli assessed as [35S]methionine incorporation method | ChEMBL. | 17681758 |
MIC90 (functional) | = 1 ug ml-1 | Antibacterial activity against Streptococcus pneumoniae by broth microdilution method | ChEMBL. | 17681758 |
MIC90 (functional) | = 2 ug ml-1 | Antibacterial activity against Staphylococcus aureus by broth microdilution method | ChEMBL. | 17681758 |
MIC90 (functional) | = 2 ug ml-1 | Antibacterial activity against Enterococcus faecalis by broth microdilution method | ChEMBL. | 17681758 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Escherichia coli | ChEMBL23 | 17681758 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.