Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0151 | 0.0675 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0297 | 0.2642 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.084 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0151 | 0.0675 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0101 | 0 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0297 | 0.2642 | 0.2642 |
Trypanosoma brucei | lipase domain protein, putative | 0.0297 | 0.2642 | 1 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0101 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0101 | 0 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.084 | 1 | 1 |
Schistosoma mansoni | amidase | 0.084 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0297 | 0.2642 | 1 |
Brugia malayi | Lipase family protein | 0.0297 | 0.2642 | 0.2642 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.084 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.084 | 1 | 1 |
Loa Loa (eye worm) | lipase | 0.0297 | 0.2642 | 0.2642 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0297 | 0.2642 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0101 | 0 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0297 | 0.2642 | 1 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0101 | 0 | 0.5 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0101 | 0 | 0.5 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0101 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0297 | 0.2642 | 0.5 |
Onchocerca volvulus | 0.0297 | 0.2642 | 0.5 | |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.084 | 1 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0297 | 0.2642 | 0.2642 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0297 | 0.2642 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Selectivity index, ratio of CC50 for Huh 5-2 cells to EC50 for HCV | ChEMBL. | 17084081 |
CC50 (ADMET) | = 24 uM | Cytotoxicity against MDBK cells | ChEMBL. | 17084081 |
CC50 (ADMET) | = 79 uM | Cytotoxicity against Huh 5-2 cells | ChEMBL. | 17084081 |
EC50 (functional) | = 0.14 uM | Antiviral activity against BVDV in MDBK cells assessed as reduction of virus-induced cytopathic efect | ChEMBL. | 17084081 |
EC50 (functional) | > 79 uM | Antiviral activity against HCV in Huh 5-2 cells assessed as reduction of virus-induced cytopathic efect | ChEMBL. | 17084081 |
Ratio CC50/EC50 (functional) | = 171 | Selectivity index, ratio of CC50 for MDBK cells to EC50 for BVDV | ChEMBL. | 17084081 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.