Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.6404 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0281 | 0.6404 | 0.6404 |
Brugia malayi | Uncoordinated protein 44 | 0.0281 | 0.6404 | 1 |
Schistosoma mansoni | netrin receptor unc5 | 0.0281 | 0.6404 | 0.6404 |
Onchocerca volvulus | Netrin receptor homolog | 0.0281 | 0.6404 | 1 |
Brugia malayi | Death domain containing protein | 0.0281 | 0.6404 | 1 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0281 | 0.6404 | 0.6404 |
Echinococcus granulosus | tumor necrosis factor receptor superfamily | 0.043 | 1 | 1 |
Echinococcus granulosus | Ankyrin | 0.0281 | 0.6404 | 0.6404 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0281 | 0.6404 | 0.6404 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0281 | 0.6404 | 0.6404 |
Schistosoma mansoni | tumor necrosis factor receptor related | 0.043 | 1 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0281 | 0.6404 | 1 |
Echinococcus multilocularis | tumor necrosis factor receptor superfamily | 0.043 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.6404 | 1 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0281 | 0.6404 | 0.6404 |
Echinococcus multilocularis | TNFR CD27 30 40 95 cysteine rich region | 0.043 | 1 | 1 |
Echinococcus multilocularis | Ankyrin | 0.0281 | 0.6404 | 0.6404 |
Echinococcus granulosus | death domain containing protein | 0.0281 | 0.6404 | 0.6404 |
Brugia malayi | Protein kinase domain containing protein | 0.0281 | 0.6404 | 1 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0281 | 0.6404 | 0.6404 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0281 | 0.6404 | 1 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0281 | 0.6404 | 0.6404 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 97 uM | Cytotoxicity against Huh 5-2 cells | ChEMBL. | 17656093 |
CC50 (ADMET) | > 104 uM | Cytotoxicity against MDBK cells | ChEMBL. | 17656093 |
EC50 (functional) | = 0.61 uM | Antiviral activity against BVDV in MDBK cells | ChEMBL. | 17656093 |
EC50 (functional) | = 84 uM | Antiviral activity against HCV in Huh 5-2 cells | ChEMBL. | 17656093 |
Ratio CC50/EC50 (functional) | = 1.15 | Selectivity index, ratio of CC50 for Huh 5-2 cells to EC50 for HCV | ChEMBL. | 17656093 |
Ratio CC50/EC50 (functional) | > 170 | Selectivity index, ratio of CC50 for MDBK cells to EC50 for BVDV | ChEMBL. | 17656093 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.