Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Small conductance calcium-activated potassium channel | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | small conductance calcium activated potassium | Small conductance calcium-activated potassium channel | 580 aa | 475 aa | 48.0 % |
Echinococcus multilocularis | small conductance calcium activated potassium | Small conductance calcium-activated potassium channel | 580 aa | 475 aa | 48.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1033 | 0.1033 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1801 | 0.1164 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1801 | 0.1164 |
Brugia malayi | chromobox protein homolog 3 | 0.0042 | 0.1546 | 0.2333 |
Schistosoma mansoni | calcium-activated potassium channel | 0.019 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1294 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.1546 | 0.2714 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0181 | 0.9472 | 0.9431 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1294 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1546 | 0.1546 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0721 | 0.1087 |
Echinococcus granulosus | chromobox protein 1 | 0.0074 | 0.341 | 0.2898 |
Onchocerca volvulus | Huntingtin homolog | 0.0131 | 0.6627 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.1294 | 0.0618 |
Echinococcus granulosus | chromobox protein 1 | 0.0074 | 0.341 | 0.2898 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1801 | 0.1164 |
Schistosoma mansoni | hypothetical protein | 0.019 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0131 | 0.6627 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.1294 | 0.1294 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0721 | 0.0721 |
Trichomonas vaginalis | chromobox protein, putative | 0.0045 | 0.1727 | 0.3419 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.1294 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.1294 | 0.1728 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.1294 | 0.0618 |
Trichomonas vaginalis | chromobox protein, putative | 0.0074 | 0.341 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.6627 | 0.6627 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.1801 | 0.1801 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.1294 | 0.1728 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1801 | 0.1164 |
Onchocerca volvulus | Huntingtin homolog | 0.0131 | 0.6627 | 1 |
Schistosoma mansoni | chromobox protein | 0.0074 | 0.341 | 0.2898 |
Schistosoma mansoni | chromobox protein | 0.0074 | 0.341 | 0.2898 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.1294 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.1294 | 0.0618 |
Onchocerca volvulus | 0.0033 | 0.1033 | 0.0528 | |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.019 | 1 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.1546 | 0.1398 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.1294 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.1546 | 0.2714 |
Echinococcus multilocularis | chromobox protein 1 | 0.0074 | 0.341 | 0.2898 |
Echinococcus multilocularis | chromobox protein 1 | 0.0074 | 0.341 | 0.2898 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.1294 | 0.0618 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1801 | 0.1164 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0721 | 0.0721 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.4599 | 0.4599 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1801 | 0.1164 |
Brugia malayi | Inositol-1 | 0.0037 | 0.1294 | 0.1953 |
Brugia malayi | Heterochromatin protein 1 | 0.0074 | 0.341 | 0.5146 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.1294 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0721 | 0.0721 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0074 | 0.341 | 0.341 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0692 | 0.0692 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0721 | 0.1087 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1294 | 0.5 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.1071 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.6627 | 0.6627 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.4042 | 0.4042 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0033 | 0.1071 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0045 | 0.1727 | 0.1704 |
Trichomonas vaginalis | chromobox protein, putative | 0.0045 | 0.1727 | 0.3419 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.1801 | 0.2718 |
Trichomonas vaginalis | chromobox protein, putative | 0.0074 | 0.341 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1294 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.1294 | 0.1728 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1801 | 0.1164 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | > 58 % | Displacement of [125I]apamin from SK channel in Wistar rat cortex at 10 uM | ChEMBL. | 17867663 |
Activity (binding) | > 58 % | Displacement of [125I]apamin from SK channel in Wistar rat cortex at 10 uM | ChEMBL. | 17867663 |
Ki (binding) | = 280 nM | Displacement of [125I]apamin from SK channel in Wistar rat cortex | ChEMBL. | 17867663 |
Ki (binding) | = 280 nM | Displacement of [125I]apamin from SK channel in Wistar rat cortex | ChEMBL. | 17867663 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.