Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | cell-cycle-associated protein kinase, putative | 0.0116 | 0.6583 | 1 |
Plasmodium falciparum | MO15-related protein kinase | 0.0124 | 0.7152 | 1 |
Echinococcus multilocularis | geminin | 0.0165 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1895 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.2631 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.2631 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.2631 | 0.3997 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.2631 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.2631 | 0.2631 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1895 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.2631 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.2631 | 0.2631 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0124 | 0.7152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1895 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1895 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0826 | 0.4359 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.2631 | 0.2631 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.2631 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.2631 | 0.2631 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0826 | 0.4359 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0826 | 0.0826 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cp (functional) | = 12 uM | Anticoagulant activity in human plasma assessed as concentration required to double prothrombin time | ChEMBL. | 17227710 |
Ki (binding) | = 1.6 nM | Binding affinity to human factor 10a after 10 mins | ChEMBL. | 17227710 |
Ki (binding) | > 5000 nM | Binding affinity to human thrombin after 10 mins | ChEMBL. | 17227710 |
Ki app (binding) | = 1.6 nM | Binding affinity to human factor 10a after 10 mins | ChEMBL. | 17227710 |
Ki app (binding) | > 5000 nM | Binding affinity to human thrombin after 10 mins | ChEMBL. | 17227710 |
Ki app (binding) | > 5000 nM | Binding affinity to bovine trypsin after 10 mins | ChEMBL. | 17227710 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.