TDR Targets

Basic information

Technical information

TDR Targets ID: 436268
Name: (E)-1-(2,6-dihydroxyphenyl)-3-phenylprop-2-en -1-one
MW: 240.254 | Formula: C15H12O3
H donors: 2 H acceptors: 3 LogP: 3.53 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1c(O)cccc1O)/C=C/c1ccccc1
InChi: 1S/C15H12O3/c16-12-7-4-8-13(17)15(12)14(18)10-9-11-5-2-1-3-6-11/h1-10,16-17H/b10-9+
InChiKey: FLGLUUFICRDIJE-MDZDMXLPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(E)-1-(2,6-dihydroxyphenyl)-3-phenyl-prop-2-en-1-one
(E)-1-(2,6-dihydroxyphenyl)-3-phenyl-2-propen-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0063	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0041	0.3524	0.4053
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.0063	0.045
Loa Loa (eye worm)	hypothetical protein	0.0042	0.3759	0.4326
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0037	0.2944	0.4409
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0026	0.1397	0.6061
Loa Loa (eye worm)	hypothetical protein	0.0061	0.6353	0.7354
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0026	0.1397	0.5
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0026	0.1397	0.3298
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.019	0.136
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0027	0.1633	0.1846
Echinococcus granulosus	serine:threonine protein kinase N2	0.0016	0.0063	0.0012
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0026	0.1397	1
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0016	0.0063	0.0011
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0016	0.0063	0.0012
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0026	0.1397	0.1353
Entamoeba histolytica	protein kinase, putative	0.0017	0.019	0.0578
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0024	0.1198	0.1152
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0026	0.1397	0.5
Onchocerca volvulus		0.0027	0.157	0.241
Brugia malayi	Cytochrome P450 family protein	0.002	0.0636	0.0877
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0037	0.2944	1
Trichomonas vaginalis	ap endonuclease, putative	0.0026	0.1397	1
Schistosoma mansoni	serine/threonine kinase	0.0016	0.0063	0.0011
Loa Loa (eye worm)	cytochrome P450 family protein	0.002	0.0636	0.0682
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0026	0.1397	0.1571
Brugia malayi	Protein kinase domain containing protein	0.0017	0.019	0.0195
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0042	0.3694	0.5557
Schistosoma mansoni	atypical protein kinase C	0.005	0.4868	0.4841
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.019	0.136
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.6597	0.658
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0063	0.0011
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0026	0.1397	0.5
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0035	0.2663	0.3048
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0026	0.1397	0.5
Loa Loa (eye worm)	hypothetical protein	0.0075	0.8414	0.976
Brugia malayi	Cytochrome P450 family protein	0.002	0.0636	0.0877
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0042	0.3694	0.4251
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0026	0.1397	1
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0016	0.0063	0.0011
Onchocerca volvulus		0.0042	0.3759	0.5883
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0024	0.1198	0.1152
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.0063	0.045
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.019	0.136
Echinococcus granulosus	NDR protein kinase	0.0016	0.0063	0.0012
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0032	0.2265	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0024	0.1198	0.1736
Loa Loa (eye worm)	hypothetical protein	0.0041	0.3631	0.4178
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0016	0.0063	0.0012
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0016	0.0063	0.0011
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0024	0.1198	0.1152
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0016	0.0063	0.0011
Trypanosoma brucei	cytochrome P450, putative	0.002	0.0636	0.3696
Schistosoma mansoni	thyroid hormone receptor	0.0087	1	1
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0062	0.6597	0.7639
Schistosoma mansoni	protein kinase C mu	0.0042	0.3694	0.3662
Brugia malayi	exodeoxyribonuclease III family protein	0.0026	0.1397	0.2042
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0037	0.2944	0.2907
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0028	0.1721	0.1948
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.019	0.136
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0026	0.1397	0.5
Onchocerca volvulus		0.0041	0.3631	0.5681
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0016	0.0063	0.0013
Onchocerca volvulus		0.0061	0.6353	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.2078	0.2365
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0024	0.1198	0.1267
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0026	0.1397	1
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.019	0.136
Loa Loa (eye worm)	hypothetical protein	0.0077	0.862	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.157	0.1772
Schistosoma mansoni	thyroid hormone receptor	0.0087	1	1
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0016	0.0063	0.0013
Echinococcus granulosus	protein kinase c iota type	0.0049	0.468	0.5119
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0037	0.2944	1
Schistosoma mansoni	ap endonuclease	0.0026	0.1397	0.1353
Schistosoma mansoni	ap endonuclease	0.0026	0.1397	0.1353
Brugia malayi	protein kinase C II.	0.0062	0.6597	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.6353	0.7354
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.5986	0.5965
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0024	0.1198	0.1337
Loa Loa (eye worm)	cytochrome P450 family protein	0.002	0.0636	0.0682
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0046	0.4341	0.4312
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0024	0.1198	0.1152
Toxoplasma gondii	exonuclease III APE	0.0026	0.1397	1
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0016	0.0063	0.0013
Loa Loa (eye worm)	CYP4Cod1	0.002	0.0636	0.0682
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0037	0.2944	1
Brugia malayi	Cytochrome P450 family protein	0.003	0.2078	0.3084
Loa Loa (eye worm)	hypothetical protein	0.0061	0.6353	0.7354
Brugia malayi	protein kinase C3,putative	0.0033	0.2476	0.3693
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0016	0.0063	0.0013
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0016	0.0063	0.0013
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.019	0.136
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0063	0.0011
Echinococcus granulosus	protein kinase c epsilon type	0.0062	0.6597	0.724
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0058	0.5986	0.5965
Echinococcus multilocularis	serine threonine protein kinase	0.0043	0.3925	0.3893
Echinococcus multilocularis	protein kinase c iota type	0.0049	0.468	0.4652
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.008	0.9093	1
Trichomonas vaginalis	AGC family protein kinase	0.0016	0.0063	0.045
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0063	0.0011
Echinococcus multilocularis	RNA directed DNA polymerase	0.0026	0.1463	0.1419
Echinococcus granulosus	serine:threonine protein kinase N2	0.0031	0.2137	0.2307
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1463	0.1647
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.019	0.136
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0026	0.1397	0.1488
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0026	0.1463	0.1419
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0037	0.2944	0.3199
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.5986	0.5965
Echinococcus multilocularis	protein kinase c epsilon type	0.0062	0.6597	0.658
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0017	0.019	0.0162
Trichomonas vaginalis	ap endonuclease, putative	0.0026	0.1397	1
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.019	0.136
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0024	0.1198	0.1267
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0016	0.0063	0.0013
Brugia malayi	C1-like domain containing protein	0.0042	0.3694	0.5557
Echinococcus granulosus	protein kinase C gamma type	0.0043	0.3925	0.4284
Echinococcus granulosus	RNA directed DNA polymerase	0.0026	0.1463	0.1561
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0037	0.2944	1
Schistosoma mansoni	hypothetical protein	0.008	0.9093	0.9088
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0037	0.2944	0.2907
Echinococcus granulosus	Protein kinase C brain isozyme	0.0058	0.5986	0.6564
Entamoeba histolytica	protein kinase, putative	0.0017	0.019	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0027	0.157	0.1772
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0016	0.0063	0.0011
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0024	0.1198	0.1152
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0016	0.0063	0.0012
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0034	0.2597	0.2971
Brugia malayi	Protein kinase c protein 2	0.0042	0.3782	0.5692
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0026	0.1397	0.3298
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.008	0.9093	0.9088

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	< 20 %	Inhibition of mushroom tyrosinase at 400 uM	ChEMBL.	17267225
Inhibition (binding)	< 20 %	Inhibition of mushroom tyrosinase at 400 uM	ChEMBL.	17267225

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10752529

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 436268